Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02041:Lcn3'

184744

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lcn3

Ensembl Gene

ENSMUSG00000026936

Gene Name

lipocalin 3

Synonyms

Vnsp1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

IGL02041

Quality Score

Status

Chromosome

Chromosomal Location

25655581-25658111 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 25655636 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 18 (V18I)

Ref Sequence

ENSEMBL: ENSMUSP00000028304 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028304]

AlphaFold

Q62471

Predicted Effect

probably benign
Transcript: ENSMUST00000028304
AA Change: V18I

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000028304
Gene: ENSMUSG00000026936
AA Change: V18I

Domain	Start	End	E-Value	Type
Pfam:Lipocalin	37	171	2.5e-23	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc2	A	T	19: 43,772,674 (GRCm39)	Q28L	probably damaging	Het
Abtb3	G	A	10: 85,223,418 (GRCm39)	D76N	unknown	Het
Afg1l	A	G	10: 42,330,376 (GRCm39)	V97A	probably damaging	Het
Akap6	A	C	12: 53,187,436 (GRCm39)	S1617R	probably damaging	Het
Aldh1a3	T	C	7: 66,057,579 (GRCm39)	N285D	probably damaging	Het
Arhgap20	A	T	9: 51,757,490 (GRCm39)	N494I	possibly damaging	Het
Atg9a	G	T	1: 75,159,748 (GRCm39)	Q712K	possibly damaging	Het
Cdcp2	G	A	4: 106,964,386 (GRCm39)		probably benign	Het
Cds2	T	A	2: 132,136,363 (GRCm39)	I84N	possibly damaging	Het
Clcn3	T	C	8: 61,376,187 (GRCm39)	I596V	probably damaging	Het
Ctxn1	A	G	8: 4,308,514 (GRCm39)	L39P	probably damaging	Het
Efhb	A	T	17: 53,733,287 (GRCm39)	V528D	probably damaging	Het
Fmod	T	G	1: 133,968,001 (GRCm39)	S14A	probably benign	Het
Foxh1	A	G	15: 76,553,120 (GRCm39)	F198S	probably damaging	Het
Gcc2	A	G	10: 58,105,103 (GRCm39)	E77G	probably damaging	Het
Gm5420	G	T	10: 21,566,933 (GRCm39)		noncoding transcript	Het
Gm6434	T	G	7: 25,581,655 (GRCm39)		noncoding transcript	Het
Il1b	A	T	2: 129,211,662 (GRCm39)	N19K	possibly damaging	Het
Lama2	T	A	10: 26,860,322 (GRCm39)	D3055V	probably damaging	Het
Lpcat2	A	G	8: 93,644,809 (GRCm39)	S533G	probably benign	Het
Map4k2	G	A	19: 6,401,348 (GRCm39)	R606Q	probably benign	Het
Mtnr1b	T	C	9: 15,774,589 (GRCm39)	T157A	probably benign	Het
Myo15a	G	A	11: 60,397,689 (GRCm39)	E2705K	probably damaging	Het
Ncf2	A	G	1: 152,711,871 (GRCm39)		probably benign	Het
Nfkbil1	G	A	17: 35,439,934 (GRCm39)	T193M	probably benign	Het
Nmi	T	G	2: 51,850,641 (GRCm39)	K9T	possibly damaging	Het
Or2d4	T	C	7: 106,543,320 (GRCm39)	D296G	possibly damaging	Het
Or5p69	T	C	7: 107,966,742 (GRCm39)	F15S	probably damaging	Het
Or6c6c	A	G	10: 129,541,104 (GRCm39)	D119G	probably damaging	Het
Osbpl7	T	A	11: 96,951,334 (GRCm39)	C502S	probably benign	Het
Pex5	A	T	6: 124,382,240 (GRCm39)		probably benign	Het
Pkhd1l1	T	A	15: 44,356,452 (GRCm39)		probably null	Het
Prmt3	C	T	7: 49,478,711 (GRCm39)	T424M	possibly damaging	Het
Rapgef4	G	A	2: 72,029,140 (GRCm39)	G404D	probably damaging	Het
Rbm5	C	T	9: 107,633,045 (GRCm39)		probably benign	Het
Rfc2	T	A	5: 134,623,098 (GRCm39)	F238L	probably benign	Het
Rsl1	A	G	13: 67,324,612 (GRCm39)	E46G	probably damaging	Het
Sall1	A	G	8: 89,758,097 (GRCm39)	F669S	probably damaging	Het
Sipa1l2	A	G	8: 126,218,558 (GRCm39)	S260P	probably benign	Het
Slc26a8	A	G	17: 28,861,225 (GRCm39)	Y820H	probably damaging	Het
Tas2r115	A	G	6: 132,714,430 (GRCm39)	F174L	probably benign	Het
Terb1	A	C	8: 105,221,746 (GRCm39)	C185G	probably damaging	Het
Vmn2r108	A	T	17: 20,683,398 (GRCm39)	V602E	probably damaging	Het
Vmn2r58	T	A	7: 41,514,703 (GRCm39)	I89F	probably damaging	Het
Vps13b	G	T	15: 35,423,391 (GRCm39)	R237L	probably damaging	Het
Zfp865	T	C	7: 5,034,372 (GRCm39)	S786P	probably benign	Het

Other mutations in Lcn3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02139:Lcn3	APN	2	25,656,646 (GRCm39)	missense	possibly damaging	0.66
IGL02221:Lcn3	APN	2	25,656,172 (GRCm39)	missense	probably benign	0.01
IGL02665:Lcn3	APN	2	25,656,416 (GRCm39)	missense	possibly damaging	0.66
IGL03049:Lcn3	APN	2	25,655,586 (GRCm39)	start codon destroyed	probably null	0.02
R0552:Lcn3	UTSW	2	25,656,421 (GRCm39)	critical splice donor site	probably null
R3522:Lcn3	UTSW	2	25,656,133 (GRCm39)	missense	possibly damaging	0.56
R4227:Lcn3	UTSW	2	25,656,123 (GRCm39)	missense	probably benign	0.00
R6684:Lcn3	UTSW	2	25,656,170 (GRCm39)	missense	probably benign	0.00
R6937:Lcn3	UTSW	2	25,657,823 (GRCm39)	nonsense	probably null
R7010:Lcn3	UTSW	2	25,656,068 (GRCm39)	missense	probably damaging	0.99
R7487:Lcn3	UTSW	2	25,656,174 (GRCm39)	critical splice donor site	probably null
R7966:Lcn3	UTSW	2	25,656,389 (GRCm39)	missense	probably damaging	1.00
R8553:Lcn3	UTSW	2	25,656,347 (GRCm39)	critical splice acceptor site	probably null
R9544:Lcn3	UTSW	2	25,656,151 (GRCm39)	missense	probably benign
R9609:Lcn3	UTSW	2	25,657,596 (GRCm39)	missense	possibly damaging	0.88

Posted On

2014-05-07