Incidental Mutation 'IGL00236:Prss43'
ID |
2264 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Prss43
|
Ensembl Gene |
ENSMUSG00000058398 |
Gene Name |
serine protease 43 |
Synonyms |
LOC272643, Tessp3 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.064)
|
Stock # |
IGL00236
|
Quality Score |
|
Status
|
|
Chromosome |
9 |
Chromosomal Location |
110655758-110660575 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to T
at 110658538 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamine to Histidine
at position 279
(Q279H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000076752
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077549]
[ENSMUST00000141089]
|
AlphaFold |
Q76HL1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000077549
AA Change: Q279H
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
SMART Domains |
Protein: ENSMUSP00000076752 Gene: ENSMUSG00000058398 AA Change: Q279H
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
low complexity region
|
41 |
49 |
N/A |
INTRINSIC |
Tryp_SPc
|
115 |
350 |
5.86e-58 |
SMART |
transmembrane domain
|
362 |
381 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000141089
|
SMART Domains |
Protein: ENSMUSP00000117039 Gene: ENSMUSG00000032493
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
Pfam:Trypsin
|
112 |
144 |
1.3e-9 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 30 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Alkbh1 |
A |
G |
12: 87,490,467 (GRCm39) |
V43A |
probably damaging |
Het |
Ankrd17 |
A |
T |
5: 90,381,787 (GRCm39) |
S2460T |
probably damaging |
Het |
Ap4e1 |
T |
C |
2: 126,870,201 (GRCm39) |
L176P |
probably damaging |
Het |
Caprin2 |
A |
G |
6: 148,744,569 (GRCm39) |
I952T |
probably damaging |
Het |
Cdkl4 |
A |
T |
17: 80,832,705 (GRCm39) |
|
probably benign |
Het |
Cfap44 |
T |
C |
16: 44,227,767 (GRCm39) |
L156P |
probably damaging |
Het |
Dock9 |
A |
G |
14: 121,905,880 (GRCm39) |
L90S |
probably benign |
Het |
Efhb |
T |
C |
17: 53,769,481 (GRCm39) |
D276G |
probably damaging |
Het |
Ep300 |
A |
G |
15: 81,525,619 (GRCm39) |
D1481G |
unknown |
Het |
Fam83b |
T |
C |
9: 76,398,260 (GRCm39) |
I948V |
probably benign |
Het |
Fbxl5 |
G |
T |
5: 43,922,678 (GRCm39) |
H247N |
probably damaging |
Het |
Fn1 |
A |
G |
1: 71,692,032 (GRCm39) |
I37T |
probably benign |
Het |
Hfe |
C |
T |
13: 23,889,835 (GRCm39) |
|
probably benign |
Het |
Ighv1-36 |
A |
T |
12: 114,843,770 (GRCm39) |
L29Q |
possibly damaging |
Het |
Inpp5e |
G |
T |
2: 26,298,533 (GRCm39) |
Q23K |
probably benign |
Het |
L3mbtl1 |
T |
C |
2: 162,808,983 (GRCm39) |
S619P |
probably damaging |
Het |
Myh8 |
T |
C |
11: 67,174,644 (GRCm39) |
I253T |
probably damaging |
Het |
Ntrk1 |
C |
T |
3: 87,698,745 (GRCm39) |
V99M |
possibly damaging |
Het |
Or51s1 |
T |
C |
7: 102,558,479 (GRCm39) |
H189R |
probably damaging |
Het |
Or5b124 |
A |
T |
19: 13,610,903 (GRCm39) |
I143F |
probably benign |
Het |
Pard6a |
T |
C |
8: 106,429,446 (GRCm39) |
S135P |
probably damaging |
Het |
Ptcd2 |
T |
C |
13: 99,466,573 (GRCm39) |
N207D |
probably benign |
Het |
Ros1 |
T |
C |
10: 52,070,986 (GRCm39) |
I23V |
probably benign |
Het |
Scg5 |
A |
G |
2: 113,657,915 (GRCm39) |
|
probably benign |
Het |
Sh3bp5 |
T |
A |
14: 31,101,347 (GRCm39) |
K212* |
probably null |
Het |
Slc25a30 |
C |
T |
14: 76,004,365 (GRCm39) |
G244D |
possibly damaging |
Het |
Slc38a10 |
T |
C |
11: 119,997,428 (GRCm39) |
R689G |
probably damaging |
Het |
Spatc1 |
A |
G |
15: 76,168,994 (GRCm39) |
D321G |
probably damaging |
Het |
Stat4 |
A |
T |
1: 52,142,037 (GRCm39) |
Y628F |
probably damaging |
Het |
Wdr35 |
G |
A |
12: 9,069,900 (GRCm39) |
V813I |
probably benign |
Het |
|
Other mutations in Prss43 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01636:Prss43
|
APN |
9 |
110,656,505 (GRCm39) |
missense |
possibly damaging |
0.75 |
IGL03046:Prss43
|
UTSW |
9 |
110,660,049 (GRCm39) |
missense |
probably benign |
0.01 |
PIT4576001:Prss43
|
UTSW |
9 |
110,656,955 (GRCm39) |
missense |
probably damaging |
1.00 |
R0020:Prss43
|
UTSW |
9 |
110,657,580 (GRCm39) |
unclassified |
probably benign |
|
R0278:Prss43
|
UTSW |
9 |
110,656,430 (GRCm39) |
missense |
probably benign |
0.07 |
R0883:Prss43
|
UTSW |
9 |
110,658,576 (GRCm39) |
missense |
probably damaging |
1.00 |
R1384:Prss43
|
UTSW |
9 |
110,656,510 (GRCm39) |
missense |
probably benign |
0.10 |
R2212:Prss43
|
UTSW |
9 |
110,658,532 (GRCm39) |
missense |
probably damaging |
1.00 |
R3412:Prss43
|
UTSW |
9 |
110,658,532 (GRCm39) |
missense |
probably damaging |
1.00 |
R3808:Prss43
|
UTSW |
9 |
110,656,840 (GRCm39) |
missense |
probably damaging |
1.00 |
R4202:Prss43
|
UTSW |
9 |
110,656,529 (GRCm39) |
missense |
probably benign |
0.08 |
R4530:Prss43
|
UTSW |
9 |
110,658,572 (GRCm39) |
missense |
probably benign |
0.38 |
R4752:Prss43
|
UTSW |
9 |
110,656,836 (GRCm39) |
missense |
possibly damaging |
0.47 |
R5009:Prss43
|
UTSW |
9 |
110,656,489 (GRCm39) |
missense |
possibly damaging |
0.50 |
R6920:Prss43
|
UTSW |
9 |
110,657,680 (GRCm39) |
missense |
probably benign |
0.04 |
R7271:Prss43
|
UTSW |
9 |
110,657,671 (GRCm39) |
missense |
probably damaging |
1.00 |
R7406:Prss43
|
UTSW |
9 |
110,657,764 (GRCm39) |
missense |
probably damaging |
1.00 |
R7758:Prss43
|
UTSW |
9 |
110,658,459 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8257:Prss43
|
UTSW |
9 |
110,659,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8686:Prss43
|
UTSW |
9 |
110,658,494 (GRCm39) |
missense |
possibly damaging |
0.92 |
R8885:Prss43
|
UTSW |
9 |
110,660,046 (GRCm39) |
missense |
probably damaging |
1.00 |
R9217:Prss43
|
UTSW |
9 |
110,656,564 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Posted On |
2011-12-09 |