Incidental Mutation 'R2427:Tafa4'
ID 250269
Institutional Source Beutler Lab
Gene Symbol Tafa4
Ensembl Gene ENSMUSG00000046500
Gene Name TAFA chemokine like family member 4
Synonyms Tafa4, Fam19a4, C130034I18Rik
MMRRC Submission 040389-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # R2427 (G1)
Quality Score 157
Status Validated
Chromosome 6
Chromosomal Location 96808164-97037374 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 96991328 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000086710 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089295]
AlphaFold Q7TPG5
Predicted Effect probably benign
Transcript: ENSMUST00000089295
SMART Domains Protein: ENSMUSP00000086710
Gene: ENSMUSG00000046500

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Pfam:TAFA 45 133 1.6e-50 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankmy1 A G 1: 92,798,529 (GRCm39) probably null Het
Atp2a1 T A 7: 126,045,755 (GRCm39) *995L probably null Het
Axin2 T A 11: 108,814,800 (GRCm39) N229K possibly damaging Het
Capn13 A T 17: 73,633,312 (GRCm39) probably benign Het
Ccdc180 A G 4: 45,929,545 (GRCm39) I1202V probably benign Het
Cep295 A G 9: 15,245,534 (GRCm39) L974P probably damaging Het
Cers3 T C 7: 66,445,541 (GRCm39) Y321H probably benign Het
Chrnb4 T C 9: 54,942,101 (GRCm39) Y391C probably benign Het
Ciao1 T C 2: 127,088,611 (GRCm39) H104R probably damaging Het
Cldn4 A T 5: 134,975,331 (GRCm39) V90E probably damaging Het
Crbn T C 6: 106,760,433 (GRCm39) E253G probably damaging Het
Ctns A G 11: 73,087,512 (GRCm39) W5R probably damaging Het
Eme1 G A 11: 94,541,801 (GRCm39) probably benign Het
Fat2 T A 11: 55,201,638 (GRCm39) T479S probably benign Het
Fbxw25 T C 9: 109,481,928 (GRCm39) N253D probably benign Het
Fer A G 17: 64,264,298 (GRCm39) I39V probably benign Het
Fmnl2 A G 2: 53,006,991 (GRCm39) M768V probably damaging Het
Frg1 T C 8: 41,867,903 (GRCm39) K24E probably damaging Het
I830077J02Rik G T 3: 105,835,320 (GRCm39) A19D probably damaging Het
Ighv1-20 C T 12: 114,687,692 (GRCm39) silent Het
Igsf9 A G 1: 172,318,306 (GRCm39) S149G probably damaging Het
Klra10 T A 6: 130,256,298 (GRCm39) I119F probably benign Het
Lrrc4b T A 7: 44,111,976 (GRCm39) I616N probably damaging Het
Lrrc71 T C 3: 87,653,309 (GRCm39) T64A probably benign Het
Ly9 A T 1: 171,434,800 (GRCm39) I31N probably damaging Het
Mef2a A G 7: 66,915,808 (GRCm39) S165P probably damaging Het
Nol4 T G 18: 22,983,755 (GRCm39) probably benign Het
Nt5el T C 13: 105,246,269 (GRCm39) F277L probably benign Het
Plxnd1 C T 6: 115,944,709 (GRCm39) probably null Het
Rab27b T C 18: 70,129,205 (GRCm39) T30A probably damaging Het
Rasa4 A G 5: 136,130,881 (GRCm39) D384G probably benign Het
Slx4 G A 16: 3,806,851 (GRCm39) L531F probably damaging Het
Tgm1 C T 14: 55,949,557 (GRCm39) probably null Het
Tpm2 T C 4: 43,523,306 (GRCm39) N17D probably damaging Het
Tyrp1 A G 4: 80,769,108 (GRCm39) T134A probably benign Het
Zfand6 T A 7: 84,283,498 (GRCm39) K35* probably null Het
Zfp648 G A 1: 154,080,819 (GRCm39) C326Y probably damaging Het
Other mutations in Tafa4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1414:Tafa4 UTSW 6 96,991,440 (GRCm39) missense probably benign
R7994:Tafa4 UTSW 6 96,840,847 (GRCm39) missense probably damaging 1.00
R9497:Tafa4 UTSW 6 96,820,831 (GRCm39) missense possibly damaging 0.71
R9597:Tafa4 UTSW 6 96,991,429 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- CTTGTAAAGGGGCCCAGAAC -3'
(R):5'- CACATTGAGGTTCTTCATCAGTCTC -3'

Sequencing Primer
(F):5'- GAACAGCCCTGCTCCAG -3'
(R):5'- GAGGTTCTTCATCAGTCTCTCTCTG -3'
Posted On 2014-11-12