Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00844:Svs6'

278003

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Svs6

Ensembl Gene

ENSMUSG00000017000

Gene Name

seminal vesicle secretory protein 6

Synonyms

Svp6, SVS VI, MSVSP99

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.104) question?

Stock #

IGL00844

Quality Score

Status

Chromosome

Chromosomal Location

164158671-164160370 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 164159507 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Threonine at position 90 (K90T)

Ref Sequence

ENSEMBL: ENSMUSP00000017144 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017144]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000017144
AA Change: K90T

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000017144
Gene: ENSMUSG00000017000
AA Change: K90T

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	33	41	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	A	T	14: 32,384,956 (GRCm39)	C336*	probably null	Het
Adgrv1	T	C	13: 81,688,238 (GRCm39)	D994G	probably damaging	Het
Arhgap36	G	T	X: 48,586,631 (GRCm39)	Q421H	probably damaging	Het
Arhgef17	A	G	7: 100,578,656 (GRCm39)	V764A	probably benign	Het
Atf7ip	T	C	6: 136,537,679 (GRCm39)	V304A	probably benign	Het
Babam2	T	A	5: 32,164,651 (GRCm39)	F299L	probably damaging	Het
Ceacam11	T	G	7: 17,707,595 (GRCm39)	D126E	possibly damaging	Het
Dlg3	C	A	X: 99,850,199 (GRCm39)	H197Q	probably damaging	Het
Dnmt3a	T	A	12: 3,955,622 (GRCm39)	L590Q	probably damaging	Het
Fras1	A	G	5: 96,682,712 (GRCm39)		probably benign	Het
Gabarapl1	T	C	6: 129,515,598 (GRCm39)	F79L	probably benign	Het
Gabbr2	A	G	4: 46,875,711 (GRCm39)	V137A	probably damaging	Het
Gphn	T	C	12: 78,711,342 (GRCm39)		probably benign	Het
Hnrnpr	A	G	4: 136,066,516 (GRCm39)	I399M	probably benign	Het
Madd	A	C	2: 90,998,213 (GRCm39)	S636A	probably damaging	Het
Pi15	T	C	1: 17,691,764 (GRCm39)		probably benign	Het
Ppp3cb	A	T	14: 20,581,754 (GRCm39)	M87K	possibly damaging	Het
Ptpro	C	A	6: 137,391,237 (GRCm39)	H786N	probably damaging	Het
Rnase11	T	C	14: 51,287,213 (GRCm39)	I114V	possibly damaging	Het
Sirt4	A	G	5: 115,617,685 (GRCm39)		probably null	Het
Stab1	T	C	14: 30,869,023 (GRCm39)	D1534G	probably damaging	Het
Sulf2	A	G	2: 165,936,412 (GRCm39)	S185P	possibly damaging	Het
Tdrd6	A	G	17: 43,928,087 (GRCm39)	M2102T	probably benign	Het
Ttll5	T	C	12: 85,890,600 (GRCm39)	V77A	probably damaging	Het
Usp9x	T	G	X: 12,994,685 (GRCm39)	S959A	probably benign	Het
Vps50	C	T	6: 3,532,177 (GRCm39)	Q227*	probably null	Het
Zfp57	C	A	17: 37,320,514 (GRCm39)	Q120K	possibly damaging	Het
Zswim2	T	C	2: 83,754,115 (GRCm39)	N182D	probably benign	Het

Other mutations in Svs6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00847:Svs6	APN	2	164,159,507 (GRCm39)	missense	possibly damaging	0.85
IGL02000:Svs6	APN	2	164,159,352 (GRCm39)	splice site	probably benign
R1108:Svs6	UTSW	2	164,159,580 (GRCm39)	critical splice donor site	probably null
R1422:Svs6	UTSW	2	164,159,580 (GRCm39)	critical splice donor site	probably null
R1733:Svs6	UTSW	2	164,159,577 (GRCm39)	splice site	probably benign
R6225:Svs6	UTSW	2	164,159,405 (GRCm39)	missense	possibly damaging	0.85
R8556:Svs6	UTSW	2	164,159,485 (GRCm39)	missense	possibly damaging	0.86

Posted On

2015-04-16