Incidental Mutation 'IGL02130:Gm14325'
| ID |
281017 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gm14325
|
| Ensembl Gene |
ENSMUSG00000095362 |
| Gene Name |
predicted gene 14325 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.181)
|
| Stock # |
IGL02130
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
177473584-177482129 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
A to G
at 177476445 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140685
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108939]
[ENSMUST00000150650]
[ENSMUST00000188914]
|
| AlphaFold |
A2AW67 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108939
|
| SMART Domains |
Protein: ENSMUSP00000104567
Gene: ENSMUSG00000095362
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
3.43e-13 |
SMART |
|
ZnF_C2H2
|
78 |
97 |
1.61e2 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
6.08e-5 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
5.99e-4 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
5.99e-4 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
467 |
489 |
1.12e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150650
|
| SMART Domains |
Protein: ENSMUSP00000118192
Gene: ENSMUSG00000095362
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
3.43e-13 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188914
|
| SMART Domains |
Protein: ENSMUSP00000140685
Gene: ENSMUSG00000095362
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
63 |
1.4e-15 |
SMART |
|
ZnF_C2H2
|
77 |
96 |
6.8e-1 |
SMART |
|
ZnF_C2H2
|
102 |
124 |
1.8e-5 |
SMART |
|
ZnF_C2H2
|
130 |
152 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
158 |
180 |
2.3e-7 |
SMART |
|
ZnF_C2H2
|
186 |
208 |
2.5e-7 |
SMART |
|
ZnF_C2H2
|
214 |
236 |
2.5e-6 |
SMART |
|
ZnF_C2H2
|
242 |
264 |
3.3e-7 |
SMART |
|
ZnF_C2H2
|
270 |
292 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
298 |
320 |
2.1e-5 |
SMART |
|
ZnF_C2H2
|
326 |
348 |
2.1e-5 |
SMART |
|
ZnF_C2H2
|
354 |
376 |
2.5e-6 |
SMART |
|
ZnF_C2H2
|
382 |
404 |
7.3e-6 |
SMART |
|
ZnF_C2H2
|
410 |
432 |
3.1e-6 |
SMART |
|
ZnF_C2H2
|
438 |
460 |
2e-7 |
SMART |
|
ZnF_C2H2
|
466 |
488 |
4.6e-6 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atxn7l1 |
A |
T |
12: 33,392,141 (GRCm39) |
K239M |
probably damaging |
Het |
| Cep164 |
T |
C |
9: 45,691,090 (GRCm39) |
E1230G |
possibly damaging |
Het |
| Fas |
A |
G |
19: 34,292,695 (GRCm39) |
T101A |
probably benign |
Het |
| Fcnb |
A |
G |
2: 27,974,801 (GRCm39) |
|
probably null |
Het |
| Gm4877 |
A |
T |
6: 42,496,991 (GRCm39) |
|
noncoding transcript |
Het |
| Heyl |
T |
C |
4: 123,140,064 (GRCm39) |
S208P |
probably benign |
Het |
| Ighv10-3 |
A |
T |
12: 114,487,121 (GRCm39) |
L100H |
probably damaging |
Het |
| Irs1 |
T |
C |
1: 82,267,188 (GRCm39) |
S343G |
probably damaging |
Het |
| Lrriq4 |
T |
A |
3: 30,704,896 (GRCm39) |
V293E |
probably damaging |
Het |
| Mbd3l1 |
A |
T |
9: 18,396,023 (GRCm39) |
R49S |
probably damaging |
Het |
| Mdga1 |
A |
G |
17: 30,076,643 (GRCm39) |
I43T |
possibly damaging |
Het |
| N4bp3 |
T |
C |
11: 51,534,773 (GRCm39) |
E430G |
possibly damaging |
Het |
| Olfml3 |
A |
G |
3: 103,644,283 (GRCm39) |
Y129H |
probably benign |
Het |
| Or4c125 |
C |
A |
2: 89,169,927 (GRCm39) |
V240F |
probably damaging |
Het |
| Or8b12i |
A |
G |
9: 20,082,654 (GRCm39) |
I71T |
probably damaging |
Het |
| Prex2 |
T |
C |
1: 11,183,023 (GRCm39) |
V424A |
probably damaging |
Het |
| Prex2 |
T |
A |
1: 11,230,386 (GRCm39) |
V804E |
probably damaging |
Het |
| Rnf103 |
T |
C |
6: 71,486,548 (GRCm39) |
L393S |
probably damaging |
Het |
| Rnf20 |
T |
C |
4: 49,644,481 (GRCm39) |
|
probably benign |
Het |
| Slc25a16 |
A |
G |
10: 62,780,137 (GRCm39) |
I299V |
probably benign |
Het |
| Tmprss2 |
A |
T |
16: 97,392,089 (GRCm39) |
C5S |
probably damaging |
Het |
| Trpv3 |
A |
C |
11: 73,170,596 (GRCm39) |
M159L |
probably benign |
Het |
| Vmn2r45 |
A |
T |
7: 8,486,556 (GRCm39) |
M244K |
possibly damaging |
Het |
|
| Other mutations in Gm14325 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02731:Gm14325
|
APN |
2 |
177,474,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02988:Gm14325
|
APN |
2 |
177,476,042 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4490:Gm14325
|
UTSW |
2 |
177,474,776 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5274:Gm14325
|
UTSW |
2 |
177,474,777 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5277:Gm14325
|
UTSW |
2 |
177,474,777 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5295:Gm14325
|
UTSW |
2 |
177,474,777 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5394:Gm14325
|
UTSW |
2 |
177,474,777 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5395:Gm14325
|
UTSW |
2 |
177,474,777 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6147:Gm14325
|
UTSW |
2 |
177,474,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6855:Gm14325
|
UTSW |
2 |
177,474,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7198:Gm14325
|
UTSW |
2 |
177,473,798 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7221:Gm14325
|
UTSW |
2 |
177,476,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8206:Gm14325
|
UTSW |
2 |
177,474,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8310:Gm14325
|
UTSW |
2 |
177,473,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Gm14325
|
UTSW |
2 |
177,474,385 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9281:Gm14325
|
UTSW |
2 |
177,473,597 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Posted On |
2015-04-16 |
Incidental Mutation