Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02140:Tas2r117'

281519

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r117

Ensembl Gene

ENSMUSG00000058349

Gene Name

taste receptor, type 2, member 117

Synonyms

T2R17, mGR17, Tas2r17, mt2r54

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

IGL02140

Quality Score

Status

Chromosome

Chromosomal Location

132779864-132780856 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 132780558 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 232 (T232K)

Ref Sequence

ENSEMBL: ENSMUSP00000069768 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068302]

AlphaFold

Q7M715

Predicted Effect

probably benign
Transcript: ENSMUST00000068302
AA Change: T232K

PolyPhen 2 Score 0.151 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000069768
Gene: ENSMUSG00000058349
AA Change: T232K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	307	1.2e-85	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	G	A	12: 71,195,034 (GRCm39)	V144I	probably benign	Het
B3gat1	A	G	9: 26,669,043 (GRCm39)	K325E	possibly damaging	Het
Cd36	T	A	5: 18,033,766 (GRCm39)		probably benign	Het
Ces3a	A	G	8: 105,782,263 (GRCm39)	E325G	probably benign	Het
Col1a2	G	A	6: 4,515,639 (GRCm39)	G136D	unknown	Het
Cyp3a25	T	G	5: 145,946,273 (GRCm39)		probably benign	Het
Cyp3a59	T	C	5: 146,039,690 (GRCm39)	L321P	probably damaging	Het
Dag1	A	G	9: 108,095,391 (GRCm39)	S34P	probably damaging	Het
Defa27	A	T	8: 21,805,674 (GRCm39)	K13*	probably null	Het
Disp2	T	C	2: 118,621,350 (GRCm39)	F694S	probably benign	Het
Dnah12	G	T	14: 26,437,732 (GRCm39)	A454S	probably benign	Het
Dync2h1	A	T	9: 7,147,791 (GRCm39)	D946E	probably benign	Het
Fcgbp	A	G	7: 27,791,379 (GRCm39)	E880G	probably damaging	Het
Fgfr4	T	C	13: 55,308,992 (GRCm39)	V371A	probably benign	Het
Frem3	G	T	8: 81,340,736 (GRCm39)	V1010F	possibly damaging	Het
Gm13283	G	A	4: 88,679,272 (GRCm39)	V88I	probably benign	Het
Gm5134	G	A	10: 75,821,945 (GRCm39)	V260I	probably benign	Het
Grhl2	A	G	15: 37,270,830 (GRCm39)		probably benign	Het
Hectd1	A	T	12: 51,820,920 (GRCm39)	W1090R	probably damaging	Het
Hydin	G	A	8: 111,293,570 (GRCm39)	V3506I	probably benign	Het
Igkc	C	T	6: 70,703,559 (GRCm39)	R47*	probably null	Het
Iglv3	T	A	16: 19,060,160 (GRCm39)	Q56L	probably damaging	Het
Impg2	T	A	16: 56,079,831 (GRCm39)	M436K	probably benign	Het
Kcnma1	T	A	14: 23,359,113 (GRCm39)	K1110N	probably damaging	Het
Marf1	T	C	16: 13,959,776 (GRCm39)	E694G	probably damaging	Het
Nup37	A	C	10: 87,994,791 (GRCm39)	K118T	probably benign	Het
Or10al7	A	G	17: 38,366,481 (GRCm39)	M1T	probably null	Het
Or4a73	T	C	2: 89,420,586 (GRCm39)	E291G	probably damaging	Het
P3h1	A	G	4: 119,095,062 (GRCm39)	D273G	probably damaging	Het
Pcsk9	T	C	4: 106,311,843 (GRCm39)	D178G	probably benign	Het
Phyhipl	T	C	10: 70,406,660 (GRCm39)	K53R	probably damaging	Het
Pkp3	T	G	7: 140,669,249 (GRCm39)	L697R	probably damaging	Het
Rab11fip3	A	G	17: 26,286,866 (GRCm39)	V429A	probably benign	Het
Rgl2	A	G	17: 34,152,098 (GRCm39)	N295S	probably damaging	Het
Spag5	A	T	11: 78,206,459 (GRCm39)	D817V	possibly damaging	Het
Thumpd1	A	G	7: 119,316,232 (GRCm39)	V239A	possibly damaging	Het
Timd4	T	A	11: 46,710,841 (GRCm39)	S248T	possibly damaging	Het
Tmem207	A	T	16: 26,335,490 (GRCm39)	N82K	probably benign	Het
Ttn	T	A	2: 76,538,557 (GRCm39)	T34714S	possibly damaging	Het
Vmn1r194	G	A	13: 22,428,706 (GRCm39)	V108I	probably benign	Het
Vmn2r24	T	A	6: 123,757,631 (GRCm39)	S166R	probably damaging	Het
Vmn2r32	A	G	7: 7,479,696 (GRCm39)	F159S	probably damaging	Het
Wdr72	A	T	9: 74,117,505 (GRCm39)	Q739L	probably benign	Het

Other mutations in Tas2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01611:Tas2r117	APN	6	132,780,450 (GRCm39)	missense	probably damaging	0.96
IGL01611:Tas2r117	APN	6	132,780,447 (GRCm39)	missense	probably benign	0.00
IGL02154:Tas2r117	APN	6	132,780,678 (GRCm39)	missense	probably benign	0.00
IGL02466:Tas2r117	APN	6	132,779,963 (GRCm39)	missense	probably benign	0.12
IGL02942:Tas2r117	APN	6	132,780,657 (GRCm39)	missense	probably benign	0.00
IGL03328:Tas2r117	APN	6	132,780,041 (GRCm39)	missense	probably benign	0.40
PIT4480001:Tas2r117	UTSW	6	132,780,014 (GRCm39)	missense	possibly damaging	0.91
R0380:Tas2r117	UTSW	6	132,780,551 (GRCm39)	nonsense	probably null
R0456:Tas2r117	UTSW	6	132,780,354 (GRCm39)	missense	probably benign	0.12
R0699:Tas2r117	UTSW	6	132,780,161 (GRCm39)	missense	probably damaging	1.00
R2118:Tas2r117	UTSW	6	132,780,129 (GRCm39)	missense	probably damaging	0.96
R2265:Tas2r117	UTSW	6	132,780,188 (GRCm39)	missense	probably benign	0.06
R4420:Tas2r117	UTSW	6	132,780,312 (GRCm39)	nonsense	probably null
R4861:Tas2r117	UTSW	6	132,780,092 (GRCm39)	missense	probably benign	0.00
R4861:Tas2r117	UTSW	6	132,780,092 (GRCm39)	missense	probably benign	0.00
R5233:Tas2r117	UTSW	6	132,780,585 (GRCm39)	missense	possibly damaging	0.95
R5384:Tas2r117	UTSW	6	132,780,117 (GRCm39)	missense	probably benign	0.04
R6750:Tas2r117	UTSW	6	132,779,817 (GRCm39)	start gained	probably benign
R6852:Tas2r117	UTSW	6	132,779,892 (GRCm39)	missense	probably benign	0.00
R6902:Tas2r117	UTSW	6	132,780,288 (GRCm39)	missense	probably damaging	0.98
R6946:Tas2r117	UTSW	6	132,780,288 (GRCm39)	missense	probably damaging	0.98
R7129:Tas2r117	UTSW	6	132,780,350 (GRCm39)	missense	probably benign	0.01
R7412:Tas2r117	UTSW	6	132,780,192 (GRCm39)	missense	probably damaging	1.00
R7733:Tas2r117	UTSW	6	132,780,138 (GRCm39)	missense	probably benign	0.02
R7768:Tas2r117	UTSW	6	132,780,485 (GRCm39)	missense	probably damaging	1.00
R7953:Tas2r117	UTSW	6	132,780,281 (GRCm39)	missense	probably damaging	1.00
R9629:Tas2r117	UTSW	6	132,780,374 (GRCm39)	missense	probably benign	0.41

Posted On

2015-04-16