Incidental Mutation 'IGL02226:Fbxo25'
ID 285369
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxo25
Ensembl Gene ENSMUSG00000038365
Gene Name F-box protein 25
Synonyms 9130015I06Rik, Fbx25
Accession Numbers
Essential gene? Probably non essential (E-score: 0.168) question?
Stock # IGL02226
Quality Score
Status
Chromosome 8
Chromosomal Location 13957803-13990522 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 13973922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000043520] [ENSMUST00000209913]
AlphaFold Q9D2Y6
Predicted Effect probably benign
Transcript: ENSMUST00000043520
SMART Domains Protein: ENSMUSP00000039544
Gene: ENSMUSG00000038365

DomainStartEndE-ValueType
low complexity region 209 222 N/A INTRINSIC
Blast:FBOX 230 271 1e-19 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000209913
Predicted Effect probably benign
Transcript: ENSMUST00000210280
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 T C 12: 53,057,250 (GRCm39) probably benign Het
Ankrd11 G A 8: 123,618,984 (GRCm39) R1602W probably damaging Het
Arhgap23 G T 11: 97,342,426 (GRCm39) R236L probably benign Het
Aurkaip1 T C 4: 155,917,028 (GRCm39) V92A probably benign Het
Cdh20 A T 1: 104,881,816 (GRCm39) probably benign Het
Ctnnd2 A G 15: 30,847,482 (GRCm39) N691S probably benign Het
Ddx24 A C 12: 103,390,717 (GRCm39) D2E possibly damaging Het
Dennd5b A G 6: 148,934,799 (GRCm39) S691P probably benign Het
Dhrs3 C T 4: 144,650,519 (GRCm39) R248W possibly damaging Het
Dlgap1 T C 17: 70,823,029 (GRCm39) S5P probably damaging Het
Dnai4 A T 4: 102,947,595 (GRCm39) I227K probably benign Het
Ep300 A T 15: 81,497,613 (GRCm39) M510L unknown Het
Gm3252 A T 14: 4,743,741 (GRCm38) K193M possibly damaging Het
Gtf3c1 T C 7: 125,267,162 (GRCm39) probably null Het
Helz2 T C 2: 180,873,483 (GRCm39) D2337G probably damaging Het
Idh1 A T 1: 65,201,081 (GRCm39) M290K probably damaging Het
Layn T C 9: 50,985,317 (GRCm39) S80G probably damaging Het
Ltbp4 C T 7: 27,006,359 (GRCm39) E1440K probably damaging Het
Mri1 T C 8: 84,982,924 (GRCm39) T166A probably damaging Het
Myod1 C T 7: 46,027,730 (GRCm39) T290I probably benign Het
Nfat5 T A 8: 108,078,154 (GRCm39) L431* probably null Het
Nle1 A T 11: 82,795,133 (GRCm39) Y299* probably null Het
Nlrp4c T A 7: 6,069,828 (GRCm39) F576L possibly damaging Het
Nudt21 G T 8: 94,746,329 (GRCm39) S123* probably null Het
Plekhg1 A C 10: 3,895,916 (GRCm39) D436A probably damaging Het
Plxna2 T C 1: 194,326,732 (GRCm39) V222A probably damaging Het
Ppp4r3c1 A C X: 88,975,518 (GRCm39) D226E probably damaging Het
Rbm14 A G 19: 4,851,745 (GRCm39) probably benign Het
Scfd1 T A 12: 51,436,164 (GRCm39) probably benign Het
Slc34a2 A G 5: 53,225,073 (GRCm39) T405A probably benign Het
Slc39a9 T A 12: 80,691,695 (GRCm39) M14K probably damaging Het
Slc39a9 G A 12: 80,691,696 (GRCm39) M14I probably damaging Het
Spast G A 17: 74,679,334 (GRCm39) probably benign Het
Spen T C 4: 141,205,457 (GRCm39) R1057G unknown Het
Sptbn4 T G 7: 27,065,132 (GRCm39) T2056P probably damaging Het
Ssrp1 T C 2: 84,870,705 (GRCm39) L148P probably damaging Het
Tdrd6 T A 17: 43,938,093 (GRCm39) H985L probably damaging Het
Tmem44 A G 16: 30,358,199 (GRCm39) probably benign Het
Vmn2r116 T A 17: 23,603,808 (GRCm39) L11Q probably null Het
Other mutations in Fbxo25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03087:Fbxo25 APN 8 13,974,019 (GRCm39) critical splice donor site probably null
IGL03112:Fbxo25 APN 8 13,971,034 (GRCm39) missense probably benign 0.18
IGL03403:Fbxo25 APN 8 13,979,423 (GRCm39) missense probably benign 0.00
R0720:Fbxo25 UTSW 8 13,985,222 (GRCm39) missense probably damaging 1.00
R0755:Fbxo25 UTSW 8 13,985,219 (GRCm39) missense probably benign 0.00
R1865:Fbxo25 UTSW 8 13,985,248 (GRCm39) missense probably damaging 1.00
R2043:Fbxo25 UTSW 8 13,971,905 (GRCm39) missense probably damaging 0.99
R4213:Fbxo25 UTSW 8 13,989,581 (GRCm39) missense probably damaging 1.00
R4248:Fbxo25 UTSW 8 13,989,617 (GRCm39) missense probably damaging 1.00
R5380:Fbxo25 UTSW 8 13,971,886 (GRCm39) missense probably benign 0.10
R7450:Fbxo25 UTSW 8 13,981,235 (GRCm39) missense probably benign 0.09
R8264:Fbxo25 UTSW 8 13,979,393 (GRCm39) missense possibly damaging 0.89
R8409:Fbxo25 UTSW 8 13,964,999 (GRCm39) nonsense probably null
R9055:Fbxo25 UTSW 8 13,965,023 (GRCm39) missense possibly damaging 0.47
R9086:Fbxo25 UTSW 8 13,989,621 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16