Incidental Mutation 'IGL02306:Prlhr'
ID 287583
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prlhr
Ensembl Gene ENSMUSG00000045052
Gene Name prolactin releasing hormone receptor
Synonyms PrRPR, LOC226278, GR3, Gpr10
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # IGL02306
Quality Score
Status
Chromosome 19
Chromosomal Location 60455170-60456742 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 60456353 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 71 (V71E)
Ref Sequence ENSEMBL: ENSMUSP00000063114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051277]
AlphaFold Q6VMN6
Predicted Effect probably damaging
Transcript: ENSMUST00000051277
AA Change: V71E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000063114
Gene: ENSMUSG00000045052
AA Change: V71E

DomainStartEndE-ValueType
Pfam:7tm_4 67 352 4.8e-9 PFAM
Pfam:7TM_GPCR_Srsx 71 350 7.4e-16 PFAM
Pfam:7tm_1 77 335 2.7e-53 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A G 3: 121,952,044 (GRCm39) Y680C probably damaging Het
Abcb11 C T 2: 69,095,801 (GRCm39) W846* probably null Het
Adam34 G A 8: 44,103,522 (GRCm39) R708C probably benign Het
Adam6a T A 12: 113,509,343 (GRCm39) L572Q possibly damaging Het
Aldoart2 A G 12: 55,612,489 (GRCm39) Y138C probably damaging Het
Amigo1 T A 3: 108,095,302 (GRCm39) F267Y probably benign Het
Car7 A G 8: 105,275,630 (GRCm39) Y137C probably damaging Het
Ccar2 A T 14: 70,379,471 (GRCm39) M509K probably benign Het
Cd160 A T 3: 96,716,139 (GRCm39) I17N possibly damaging Het
Cmya5 C T 13: 93,234,527 (GRCm39) G187D probably damaging Het
Crot A T 5: 9,018,701 (GRCm39) V555E possibly damaging Het
Cstf1 C T 2: 172,214,891 (GRCm39) T4I probably benign Het
Cyp2a12 A G 7: 26,732,008 (GRCm39) K250E probably damaging Het
Deaf1 T C 7: 140,904,094 (GRCm39) probably null Het
Dse C T 10: 34,036,130 (GRCm39) E249K probably damaging Het
E4f1 G T 17: 24,665,903 (GRCm39) R88S probably damaging Het
Fam83a A C 15: 57,858,704 (GRCm39) D248A probably damaging Het
Fhip2b T C 14: 70,826,437 (GRCm39) D217G probably benign Het
Hadhb T A 5: 30,371,747 (GRCm39) L66Q probably null Het
Kalrn T C 16: 34,130,897 (GRCm39) E440G probably damaging Het
Kif3b A G 2: 153,162,572 (GRCm39) Y527C probably damaging Het
Krt4 T C 15: 101,829,740 (GRCm39) I263V probably benign Het
Krtap29-1 A T 11: 99,869,092 (GRCm39) V263E probably damaging Het
Mms19 A G 19: 41,954,703 (GRCm39) L72P probably damaging Het
Mylpf T A 7: 126,812,330 (GRCm39) probably benign Het
Nalcn T A 14: 123,560,750 (GRCm39) I776F probably benign Het
Nedd4l T G 18: 65,306,025 (GRCm39) S292R possibly damaging Het
Nlrc3 A C 16: 3,782,688 (GRCm39) D240E probably damaging Het
Obscn A T 11: 58,890,497 (GRCm39) I7345N unknown Het
Or4c102 A T 2: 88,422,950 (GRCm39) K267N probably benign Het
Ostn A T 16: 27,165,691 (GRCm39) S127C probably damaging Het
Patl1 A G 19: 11,920,250 (GRCm39) K735E possibly damaging Het
Pde12 A G 14: 26,389,533 (GRCm39) L392P possibly damaging Het
Plxdc2 A G 2: 16,665,585 (GRCm39) I213V probably benign Het
Plxna4 T A 6: 32,183,059 (GRCm39) Y948F probably benign Het
Prlr C T 15: 10,328,760 (GRCm39) P412S probably benign Het
Prmt9 A G 8: 78,287,447 (GRCm39) K196R probably benign Het
Rundc3a T A 11: 102,291,764 (GRCm39) L387Q probably damaging Het
Ryr3 T C 2: 112,664,459 (GRCm39) I1611V probably damaging Het
Ryr3 A G 2: 112,677,744 (GRCm39) probably null Het
Scart1 T C 7: 139,803,269 (GRCm39) C278R probably damaging Het
Sfxn2 T A 19: 46,578,987 (GRCm39) M240K probably damaging Het
Skor2 T C 18: 76,950,374 (GRCm39) S901P probably benign Het
Smad4 T C 18: 73,795,940 (GRCm39) probably null Het
Snrnp40 T G 4: 130,258,893 (GRCm39) C100W probably benign Het
Spink5 T A 18: 44,097,511 (GRCm39) D19E probably damaging Het
Sult1d1 T A 5: 87,703,914 (GRCm39) probably benign Het
Wdr59 G A 8: 112,219,365 (GRCm39) L231F probably damaging Het
Other mutations in Prlhr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Prlhr APN 19 60,456,119 (GRCm39) missense probably damaging 1.00
IGL02398:Prlhr APN 19 60,455,753 (GRCm39) missense probably damaging 1.00
IGL02506:Prlhr APN 19 60,456,366 (GRCm39) missense probably damaging 1.00
R0718:Prlhr UTSW 19 60,456,497 (GRCm39) nonsense probably null
R0718:Prlhr UTSW 19 60,456,443 (GRCm39) missense probably benign 0.00
R1829:Prlhr UTSW 19 60,455,867 (GRCm39) missense probably damaging 1.00
R1886:Prlhr UTSW 19 60,455,932 (GRCm39) nonsense probably null
R4493:Prlhr UTSW 19 60,455,519 (GRCm39) missense probably benign 0.04
R4494:Prlhr UTSW 19 60,455,519 (GRCm39) missense probably benign 0.04
R4495:Prlhr UTSW 19 60,455,519 (GRCm39) missense probably benign 0.04
R5762:Prlhr UTSW 19 60,455,506 (GRCm39) nonsense probably null
R5869:Prlhr UTSW 19 60,456,059 (GRCm39) missense probably damaging 0.96
R5886:Prlhr UTSW 19 60,456,014 (GRCm39) nonsense probably null
R7651:Prlhr UTSW 19 60,455,583 (GRCm39) missense probably benign 0.13
R7809:Prlhr UTSW 19 60,456,293 (GRCm39) missense probably damaging 1.00
R8141:Prlhr UTSW 19 60,455,747 (GRCm39) missense probably damaging 1.00
R8337:Prlhr UTSW 19 60,456,284 (GRCm39) missense possibly damaging 0.88
R8481:Prlhr UTSW 19 60,456,125 (GRCm39) missense possibly damaging 0.95
R8560:Prlhr UTSW 19 60,456,635 (GRCm39) start gained probably benign
Z1177:Prlhr UTSW 19 60,455,753 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16