Incidental Mutation 'IGL02306:Prlhr'
ID287583
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prlhr
Ensembl Gene ENSMUSG00000045052
Gene Nameprolactin releasing hormone receptor
SynonymsGpr10, LOC226278, PrRPR, GR3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.078) question?
Stock #IGL02306
Quality Score
Status
Chromosome19
Chromosomal Location60466733-60468304 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 60467915 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 71 (V71E)
Ref Sequence ENSEMBL: ENSMUSP00000063114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051277]
Predicted Effect probably damaging
Transcript: ENSMUST00000051277
AA Change: V71E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000063114
Gene: ENSMUSG00000045052
AA Change: V71E

DomainStartEndE-ValueType
Pfam:7tm_4 67 352 4.8e-9 PFAM
Pfam:7TM_GPCR_Srsx 71 350 7.4e-16 PFAM
Pfam:7tm_1 77 335 2.7e-53 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A G 3: 122,158,395 Y680C probably damaging Het
Abcb11 C T 2: 69,265,457 W846* probably null Het
Adam34 G A 8: 43,650,485 R708C probably benign Het
Adam6a T A 12: 113,545,723 L572Q possibly damaging Het
Aldoart2 A G 12: 55,565,704 Y138C probably damaging Het
Amigo1 T A 3: 108,187,986 F267Y probably benign Het
Car7 A G 8: 104,548,998 Y137C probably damaging Het
Ccar2 A T 14: 70,142,022 M509K probably benign Het
Cd160 A T 3: 96,808,823 I17N possibly damaging Het
Cd163l1 T C 7: 140,223,356 C278R probably damaging Het
Cmya5 C T 13: 93,098,019 G187D probably damaging Het
Crot A T 5: 8,968,701 V555E possibly damaging Het
Cstf1 C T 2: 172,372,971 T4I probably benign Het
Cyp2a12 A G 7: 27,032,583 K250E probably damaging Het
Deaf1 T C 7: 141,324,181 probably null Het
Dse C T 10: 34,160,134 E249K probably damaging Het
E4f1 G T 17: 24,446,929 R88S probably damaging Het
Fam160b2 T C 14: 70,588,997 D217G probably benign Het
Fam83a A C 15: 57,995,308 D248A probably damaging Het
Hadhb T A 5: 30,166,749 L66Q probably null Het
Kalrn T C 16: 34,310,527 E440G probably damaging Het
Kif3b A G 2: 153,320,652 Y527C probably damaging Het
Krt4 T C 15: 101,921,305 I263V probably benign Het
Krtap29-1 A T 11: 99,978,266 V263E probably damaging Het
Mms19 A G 19: 41,966,264 L72P probably damaging Het
Mylpf T A 7: 127,213,158 probably benign Het
Nalcn T A 14: 123,323,338 I776F probably benign Het
Nedd4l T G 18: 65,172,954 S292R possibly damaging Het
Nlrc3 A C 16: 3,964,824 D240E probably damaging Het
Obscn A T 11: 58,999,671 I7345N unknown Het
Olfr1189 A T 2: 88,592,606 K267N probably benign Het
Ostn A T 16: 27,346,941 S127C probably damaging Het
Patl1 A G 19: 11,942,886 K735E possibly damaging Het
Pde12 A G 14: 26,668,378 L392P possibly damaging Het
Plxdc2 A G 2: 16,660,774 I213V probably benign Het
Plxna4 T A 6: 32,206,124 Y948F probably benign Het
Prlr C T 15: 10,328,674 P412S probably benign Het
Prmt9 A G 8: 77,560,818 K196R probably benign Het
Rundc3a T A 11: 102,400,938 L387Q probably damaging Het
Ryr3 T C 2: 112,834,114 I1611V probably damaging Het
Ryr3 A G 2: 112,847,399 probably null Het
Sfxn2 T A 19: 46,590,548 M240K probably damaging Het
Skor2 T C 18: 76,862,679 S901P probably benign Het
Smad4 T C 18: 73,662,869 probably null Het
Snrnp40 T G 4: 130,365,100 C100W probably benign Het
Spink5 T A 18: 43,964,444 D19E probably damaging Het
Sult1d1 T A 5: 87,556,055 probably benign Het
Wdr59 G A 8: 111,492,733 L231F probably damaging Het
Other mutations in Prlhr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Prlhr APN 19 60467681 missense probably damaging 1.00
IGL02398:Prlhr APN 19 60467315 missense probably damaging 1.00
IGL02506:Prlhr APN 19 60467928 missense probably damaging 1.00
R0718:Prlhr UTSW 19 60468005 missense probably benign 0.00
R0718:Prlhr UTSW 19 60468059 nonsense probably null
R1829:Prlhr UTSW 19 60467429 missense probably damaging 1.00
R1886:Prlhr UTSW 19 60467494 nonsense probably null
R4493:Prlhr UTSW 19 60467081 missense probably benign 0.04
R4494:Prlhr UTSW 19 60467081 missense probably benign 0.04
R4495:Prlhr UTSW 19 60467081 missense probably benign 0.04
R5762:Prlhr UTSW 19 60467068 nonsense probably null
R5869:Prlhr UTSW 19 60467621 missense probably damaging 0.96
R5886:Prlhr UTSW 19 60467576 nonsense probably null
Posted On2015-04-16