Incidental Mutation 'IGL02353:Ccnl1'
ID289566
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccnl1
Ensembl Gene ENSMUSG00000027829
Gene Namecyclin L1
Synonyms2610030E23Rik, ania-6a
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.750) question?
Stock #IGL02353
Quality Score
Status
Chromosome3
Chromosomal Location65946151-65958249 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 65948720 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Glycine at position 255 (C255G)
Ref Sequence ENSEMBL: ENSMUSP00000029416 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029416] [ENSMUST00000129002] [ENSMUST00000135719] [ENSMUST00000154585]
Predicted Effect probably damaging
Transcript: ENSMUST00000029416
AA Change: C255G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029416
Gene: ENSMUSG00000027829
AA Change: C255G

DomainStartEndE-ValueType
low complexity region 2 45 N/A INTRINSIC
CYCLIN 94 196 3.55e-11 SMART
Cyclin_C 205 320 7.79e-5 SMART
CYCLIN 209 293 9.01e-13 SMART
low complexity region 386 445 N/A INTRINSIC
low complexity region 464 485 N/A INTRINSIC
low complexity region 494 532 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122919
Predicted Effect probably benign
Transcript: ENSMUST00000129002
SMART Domains Protein: ENSMUSP00000118377
Gene: ENSMUSG00000027829

DomainStartEndE-ValueType
low complexity region 2 45 N/A INTRINSIC
CYCLIN 94 174 3.93e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132998
Predicted Effect probably benign
Transcript: ENSMUST00000135719
SMART Domains Protein: ENSMUSP00000118394
Gene: ENSMUSG00000027829

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
CYCLIN 62 142 3.93e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142153
Predicted Effect probably benign
Transcript: ENSMUST00000144810
Predicted Effect probably benign
Transcript: ENSMUST00000145186
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146284
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148623
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149160
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149729
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150304
Predicted Effect probably benign
Transcript: ENSMUST00000154585
SMART Domains Protein: ENSMUSP00000119229
Gene: ENSMUSG00000027829

DomainStartEndE-ValueType
low complexity region 2 45 N/A INTRINSIC
CYCLIN 94 174 3.93e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
8030411F24Rik A G 2: 148,783,467 probably benign Het
Aldh18a1 A T 19: 40,577,920 V102D probably damaging Het
Car4 C T 11: 84,965,767 P294S probably damaging Het
Casp6 C T 3: 129,910,526 S87L probably damaging Het
Ccdc121 T C 1: 181,510,625 E254G possibly damaging Het
Celf4 T C 18: 25,486,898 I485M probably damaging Het
Cntln A G 4: 85,049,850 R769G probably damaging Het
Cyp2d12 T C 15: 82,558,970 V360A probably benign Het
Dgki T C 6: 36,847,389 E1068G probably damaging Het
Fbxl4 A G 4: 22,433,684 N607S probably benign Het
Fgd4 T C 16: 16,462,045 I383V probably damaging Het
Fgd6 C T 10: 94,138,396 T1333I possibly damaging Het
Got1 A G 19: 43,524,443 S5P probably damaging Het
Herc2 T A 7: 56,114,812 N995K probably damaging Het
Kcnma1 A G 14: 23,591,613 F159S probably damaging Het
Krt83 T C 15: 101,485,458 S456G probably benign Het
Lhb T C 7: 45,421,294 V32A possibly damaging Het
Mau2 A T 8: 70,019,638 V602E probably damaging Het
Mpst C T 15: 78,410,085 L6F probably damaging Het
Nlrp2 G A 7: 5,337,599 T72I probably damaging Het
Olfr44 A G 9: 39,485,148 I32T probably benign Het
Phldb2 T C 16: 45,748,779 Y1239C probably damaging Het
Slc22a8 T C 19: 8,608,255 F328S possibly damaging Het
Spns1 C T 7: 126,375,140 R94Q probably damaging Het
Sult2a3 G A 7: 14,121,650 R94* probably null Het
Syt16 A G 12: 74,129,471 N38S probably damaging Het
Tbc1d1 G A 5: 64,256,836 R180Q probably damaging Het
Ush2a T C 1: 188,728,438 I2632T probably benign Het
Vcam1 T A 3: 116,115,894 I595F possibly damaging Het
Other mutations in Ccnl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01969:Ccnl1 APN 3 65948487 splice site probably benign
IGL02360:Ccnl1 APN 3 65948720 missense probably damaging 1.00
IGL02454:Ccnl1 APN 3 65956897 missense probably damaging 0.99
R1598:Ccnl1 UTSW 3 65946770 missense probably damaging 0.97
R1903:Ccnl1 UTSW 3 65946911 missense possibly damaging 0.73
R2392:Ccnl1 UTSW 3 65948752 missense probably damaging 1.00
R3879:Ccnl1 UTSW 3 65948758 missense possibly damaging 0.85
R4607:Ccnl1 UTSW 3 65946710 utr 3 prime probably benign
R4608:Ccnl1 UTSW 3 65946710 utr 3 prime probably benign
R4739:Ccnl1 UTSW 3 65946671 utr 3 prime probably benign
R4885:Ccnl1 UTSW 3 65956899 missense probably damaging 1.00
R5833:Ccnl1 UTSW 3 65948501 missense probably benign 0.23
R5933:Ccnl1 UTSW 3 65948342 missense probably damaging 1.00
R6933:Ccnl1 UTSW 3 65947952 missense probably benign 0.00
Posted On2015-04-16