Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02479:Wdr25'

295095

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr25

Ensembl Gene

ENSMUSG00000040877

Gene Name

WD repeat domain 25

Synonyms

B930090D16Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.932) question?

Stock #

IGL02479

Quality Score

Status

Chromosome

Chromosomal Location

108860155-108994380 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 108864527 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 224 (T224K)

Ref Sequence

ENSEMBL: ENSMUSP00000129855 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047115] [ENSMUST00000109848] [ENSMUST00000160477] [ENSMUST00000162748] [ENSMUST00000167816] [ENSMUST00000220495] [ENSMUST00000220667] [ENSMUST00000221377]

AlphaFold

E9Q349

Predicted Effect

probably benign
Transcript: ENSMUST00000047115
AA Change: T224K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000035553
Gene: ENSMUSG00000040877
AA Change: T224K

Domain	Start	End	E-Value	Type
low complexity region	120	132	N/A	INTRINSIC
low complexity region	180	206	N/A	INTRINSIC
WD40	226	268	1.83e-7	SMART
WD40	272	311	6.73e-6	SMART
WD40	312	353	2.58e-1	SMART
Blast:WD40	356	402	7e-11	BLAST
Blast:WD40	407	445	6e-8	BLAST
WD40	451	492	9.6e-2	SMART
WD40	495	535	3e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109848

SMART Domains

Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266

Domain	Start	End	E-Value	Type
WHEP-TRS	16	72	3.01e-23	SMART
Pfam:tRNA-synt_1b	155	447	5.8e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000160477

Predicted Effect

probably benign
Transcript: ENSMUST00000162748

SMART Domains

Protein: ENSMUSP00000125102
Gene: ENSMUSG00000021266

Domain	Start	End	E-Value	Type
PDB:2QUK\|A	4	37	1e-8	PDB
SCOP:d1fyja_	14	37	8e-7	SMART
Blast:WHEP	16	37	3e-7	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000167816
AA Change: T224K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129855
Gene: ENSMUSG00000040877
AA Change: T224K

Domain	Start	End	E-Value	Type
low complexity region	120	132	N/A	INTRINSIC
low complexity region	180	206	N/A	INTRINSIC
WD40	226	268	1.83e-7	SMART
WD40	272	311	6.73e-6	SMART
WD40	312	353	2.58e-1	SMART
Blast:WD40	356	402	7e-11	BLAST
Blast:WD40	407	445	6e-8	BLAST
WD40	451	492	9.6e-2	SMART
WD40	495	535	3e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000220495

Predicted Effect

probably benign
Transcript: ENSMUST00000220667

Predicted Effect

probably benign
Transcript: ENSMUST00000221377

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam1b	T	C	5: 121,639,461 (GRCm39)	Y528C	probably damaging	Het
Adam24	T	A	8: 41,132,571 (GRCm39)	I13N	probably benign	Het
Arsj	T	C	3: 126,232,588 (GRCm39)	S445P	possibly damaging	Het
Btf3l4	G	A	4: 108,683,373 (GRCm39)	T31I	possibly damaging	Het
Cask	A	T	X: 13,423,297 (GRCm39)	D502E	probably damaging	Het
Cenpl	T	A	1: 160,910,637 (GRCm39)	S195T	probably benign	Het
Clhc1	T	A	11: 29,528,107 (GRCm39)	I545N	probably damaging	Het
Clrn2	T	C	5: 45,621,254 (GRCm39)	I216T	probably benign	Het
Csf2rb	C	T	15: 78,225,924 (GRCm39)	Q332*	probably null	Het
Cyp3a44	T	C	5: 145,727,477 (GRCm39)	D284G	probably benign	Het
Dgka	T	C	10: 128,566,115 (GRCm39)	E345G	probably benign	Het
Dync1i2	G	A	2: 71,066,323 (GRCm39)	V128I	probably damaging	Het
Eno3	T	A	11: 70,551,714 (GRCm39)		probably benign	Het
Epc2	T	A	2: 49,422,147 (GRCm39)	I347K	probably benign	Het
F8	A	T	X: 74,331,846 (GRCm39)	N681K	probably damaging	Het
Fancm	T	A	12: 65,153,259 (GRCm39)	D1238E	probably damaging	Het
Fcna	T	A	2: 25,515,272 (GRCm39)	Q237L	probably benign	Het
Fpr2	A	T	17: 18,113,074 (GRCm39)	R23S	probably benign	Het
Frmd3	A	G	4: 74,105,752 (GRCm39)	D466G	probably benign	Het
Gen1	C	A	12: 11,291,936 (GRCm39)	V618L	probably benign	Het
Gja4	T	C	4: 127,206,217 (GRCm39)	E182G	probably benign	Het
Gsdmc	T	A	15: 63,649,824 (GRCm39)	I356F	possibly damaging	Het
Kctd19	T	C	8: 106,111,400 (GRCm39)	D102G	probably damaging	Het
Lrit2	T	C	14: 36,794,235 (GRCm39)	L433P	probably damaging	Het
Lrp2	G	A	2: 69,295,145 (GRCm39)		probably benign	Het
Luc7l3	G	A	11: 94,187,735 (GRCm39)		probably benign	Het
Map3k5	T	A	10: 19,932,230 (GRCm39)	L458Q	probably damaging	Het
Mast4	A	G	13: 102,878,545 (GRCm39)	S1038P	probably damaging	Het
Med12	A	T	X: 100,340,598 (GRCm39)		probably benign	Het
Mtor	T	A	4: 148,555,041 (GRCm39)	L888M	probably damaging	Het
Nova1	A	T	12: 46,863,701 (GRCm39)	I83N	unknown	Het
Obscn	A	G	11: 58,947,053 (GRCm39)		probably benign	Het
Or11q2	T	C	X: 48,772,742 (GRCm39)	V121A	probably benign	Het
Or4d10c	T	A	19: 12,065,269 (GRCm39)	M296L	probably benign	Het
Or4f15	A	C	2: 111,813,730 (GRCm39)	S230A	probably benign	Het
Or6k2	C	A	1: 173,986,520 (GRCm39)	Y60*	probably null	Het
Pde2a	A	G	7: 101,150,290 (GRCm39)	Y243C	probably damaging	Het
Pdzd8	T	A	19: 59,288,215 (GRCm39)	K1062*	probably null	Het
Phc1	A	T	6: 122,300,676 (GRCm39)		probably benign	Het
Pik3c2g	T	A	6: 139,863,730 (GRCm39)	S764T	probably benign	Het
Pmp2	T	G	3: 10,247,262 (GRCm39)	R89S	probably benign	Het
Prdm2	A	G	4: 142,861,499 (GRCm39)	L597P	probably damaging	Het
Rfx6	T	A	10: 51,554,424 (GRCm39)	D88E	probably benign	Het
Rgs9	T	C	11: 109,116,478 (GRCm39)	S442G	possibly damaging	Het
Ror2	C	T	13: 53,285,968 (GRCm39)	R82Q	possibly damaging	Het
Sez6	C	A	11: 77,868,852 (GRCm39)	A986E	possibly damaging	Het
Slc5a5	T	A	8: 71,341,555 (GRCm39)	M325L	possibly damaging	Het
Slx9	T	C	10: 77,350,161 (GRCm39)	S76G	probably damaging	Het
Sppl2c	G	A	11: 104,077,763 (GRCm39)	V188I	probably benign	Het
Srrm3	G	T	5: 135,864,103 (GRCm39)	C67F	probably damaging	Het
Stk31	A	G	6: 49,398,622 (GRCm39)	E341G	probably damaging	Het
Svil	A	T	18: 5,099,476 (GRCm39)	M1267L	probably damaging	Het
Tas2r135	C	T	6: 42,382,685 (GRCm39)	R75*	probably null	Het
Trav8d-1	T	C	14: 53,016,257 (GRCm39)	S48P	probably benign	Het
Vrk1	A	T	12: 106,017,261 (GRCm39)	Q95L	probably benign	Het
Wdr37	A	T	13: 8,892,820 (GRCm39)	H224Q	probably damaging	Het
Zhx1	C	T	15: 57,917,767 (GRCm39)	E160K	probably damaging	Het

Other mutations in Wdr25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00946:Wdr25	APN	12	108,990,953 (GRCm39)	missense	possibly damaging	0.89
IGL02672:Wdr25	APN	12	108,864,007 (GRCm39)	nonsense	probably null
IGL03329:Wdr25	APN	12	108,864,262 (GRCm39)	missense	probably benign
R1061:Wdr25	UTSW	12	108,958,725 (GRCm39)	splice site	probably null
R1402:Wdr25	UTSW	12	108,992,465 (GRCm39)	missense	probably damaging	1.00
R1402:Wdr25	UTSW	12	108,992,465 (GRCm39)	missense	probably damaging	1.00
R1582:Wdr25	UTSW	12	108,863,980 (GRCm39)	missense	possibly damaging	0.94
R1764:Wdr25	UTSW	12	108,992,364 (GRCm39)	nonsense	probably null
R1954:Wdr25	UTSW	12	108,864,467 (GRCm39)	missense	probably damaging	0.99
R2258:Wdr25	UTSW	12	108,864,100 (GRCm39)	missense	possibly damaging	0.94
R3770:Wdr25	UTSW	12	108,864,346 (GRCm39)	missense	probably damaging	0.97
R3803:Wdr25	UTSW	12	108,864,479 (GRCm39)	missense	probably damaging	1.00
R3948:Wdr25	UTSW	12	108,993,208 (GRCm39)	missense	probably benign	0.02
R4183:Wdr25	UTSW	12	108,993,257 (GRCm39)	missense	probably benign	0.00
R5246:Wdr25	UTSW	12	108,993,382 (GRCm39)	missense	probably benign	0.06
R5290:Wdr25	UTSW	12	108,863,968 (GRCm39)	missense	probably benign	0.26
R5305:Wdr25	UTSW	12	108,992,366 (GRCm39)	missense	probably damaging	1.00
R5813:Wdr25	UTSW	12	108,993,347 (GRCm39)	missense	possibly damaging	0.47
R5942:Wdr25	UTSW	12	108,864,392 (GRCm39)	missense	probably benign	0.00
R6386:Wdr25	UTSW	12	108,990,991 (GRCm39)	missense	probably damaging	1.00
R7171:Wdr25	UTSW	12	108,990,922 (GRCm39)	missense	probably damaging	0.98
R7449:Wdr25	UTSW	12	108,992,367 (GRCm39)	missense	probably damaging	1.00
R7616:Wdr25	UTSW	12	108,958,819 (GRCm39)	missense	possibly damaging	0.73
R7617:Wdr25	UTSW	12	108,958,819 (GRCm39)	missense	possibly damaging	0.73
R7619:Wdr25	UTSW	12	108,958,819 (GRCm39)	missense	possibly damaging	0.73
R7622:Wdr25	UTSW	12	108,958,819 (GRCm39)	missense	possibly damaging	0.73
R7623:Wdr25	UTSW	12	108,958,819 (GRCm39)	missense	possibly damaging	0.73
R7984:Wdr25	UTSW	12	108,976,983 (GRCm39)	splice site	probably null
R8504:Wdr25	UTSW	12	108,992,393 (GRCm39)	nonsense	probably null
R9598:Wdr25	UTSW	12	108,864,613 (GRCm39)	missense	probably benign	0.10

Posted On

2015-04-16