Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02583:Rwdd1'

299435

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rwdd1

Ensembl Gene

ENSMUSG00000019782

Gene Name

RWD domain containing 1

Synonyms

2610002D06Rik, 2700069A07Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02583

Quality Score

Status

Chromosome

Chromosomal Location

33872551-33895612 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 33877669 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 178 (K178*)

Ref Sequence

ENSEMBL: ENSMUSP00000019917 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019917]

AlphaFold

Q9CQK7

Predicted Effect

probably null
Transcript: ENSMUST00000019917
AA Change: K178*

SMART Domains

Protein: ENSMUSP00000019917
Gene: ENSMUSG00000019782
AA Change: K178*

Domain	Start	End	E-Value	Type
RWD	10	114	1.53e-26	SMART
low complexity region	123	139	N/A	INTRINSIC
Blast:RWD	157	200	2e-10	BLAST
low complexity region	217	231	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128699

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219414

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930584F24Rik	C	T	5: 26,684,717 (GRCm39)		noncoding transcript	Het
A430005L14Rik	T	A	4: 154,045,392 (GRCm39)	D140E	possibly damaging	Het
Bod1l	C	T	5: 41,973,550 (GRCm39)		probably null	Het
Brms1	T	A	19: 5,096,206 (GRCm39)	V61D	probably damaging	Het
Card11	A	T	5: 140,863,881 (GRCm39)	N952K	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cimap2	A	T	4: 106,468,602 (GRCm39)		probably benign	Het
Col15a1	T	C	4: 47,279,866 (GRCm39)	V697A	probably benign	Het
Col7a1	A	T	9: 108,791,297 (GRCm39)	I1118F	unknown	Het
Cyfip2	T	C	11: 46,140,585 (GRCm39)	E746G	possibly damaging	Het
Dach1	A	G	14: 98,065,830 (GRCm39)		probably benign	Het
Dock11	G	T	X: 35,270,370 (GRCm39)	G1023W	possibly damaging	Het
Fbxo10	T	C	4: 45,044,754 (GRCm39)	D453G	probably damaging	Het
Fhad1	T	C	4: 141,738,955 (GRCm39)		probably benign	Het
Gm17415	A	G	1: 93,349,801 (GRCm39)		probably benign	Het
Gm4781	A	T	10: 100,232,507 (GRCm39)		noncoding transcript	Het
Gpatch2	A	C	1: 186,965,514 (GRCm39)		probably null	Het
Gpatch2	G	T	1: 186,965,515 (GRCm39)		probably null	Het
Greb1	A	G	12: 16,756,296 (GRCm39)		probably benign	Het
Greb1l	A	G	18: 10,542,362 (GRCm39)	Y1319C	probably damaging	Het
Ice1	C	T	13: 70,753,854 (GRCm39)	R744H	possibly damaging	Het
Kcnq2	T	A	2: 180,723,295 (GRCm39)	S694C	probably benign	Het
Krt35	C	A	11: 99,983,360 (GRCm39)	V448L	possibly damaging	Het
Lmo7	A	G	14: 102,171,360 (GRCm39)		probably benign	Het
Megf8	T	C	7: 25,055,218 (GRCm39)	S1984P	probably benign	Het
Nlrp1a	T	C	11: 71,014,227 (GRCm39)	Q341R	probably benign	Het
Or1p1	T	A	11: 74,180,330 (GRCm39)	L286Q	probably damaging	Het
Or51a6	T	C	7: 102,603,918 (GRCm39)	T297A	possibly damaging	Het
Osr1	C	T	12: 9,629,675 (GRCm39)	H183Y	probably damaging	Het
Paf1	T	C	7: 28,095,596 (GRCm39)	V202A	probably damaging	Het
Pde10a	A	G	17: 9,200,462 (GRCm39)	K1071E	probably benign	Het
Pwp2	T	C	10: 78,016,917 (GRCm39)	R268G	probably benign	Het
Scn10a	A	T	9: 119,520,506 (GRCm39)		probably benign	Het
Sema3g	A	G	14: 30,943,476 (GRCm39)		probably null	Het
Slc22a6	C	A	19: 8,600,980 (GRCm39)	A391E	possibly damaging	Het
Slc41a3	G	A	6: 90,621,153 (GRCm39)	G372S	probably damaging	Het
Sqor	G	T	2: 122,641,690 (GRCm39)	K3N	probably damaging	Het
Srl	T	C	16: 4,310,244 (GRCm39)	Q495R	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Stxbp3	G	T	3: 108,708,187 (GRCm39)	D371E	probably damaging	Het
Tnfrsf19	C	A	14: 61,261,659 (GRCm39)	V47F	probably damaging	Het
Usp11	A	T	X: 20,584,284 (GRCm39)	E622V	probably benign	Het
Vmn1r52	T	A	6: 90,156,126 (GRCm39)	Y143*	probably null	Het
Zfp280d	A	G	9: 72,229,727 (GRCm39)		probably benign	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het
Zmat1	T	C	X: 133,874,021 (GRCm39)	T457A	probably damaging	Het

Other mutations in Rwdd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02996:Rwdd1	APN	10	33,878,512 (GRCm39)	missense	probably damaging	0.98
R2255:Rwdd1	UTSW	10	33,878,466 (GRCm39)	missense	probably damaging	1.00
R4915:Rwdd1	UTSW	10	33,885,074 (GRCm39)	missense	possibly damaging	0.75
R5981:Rwdd1	UTSW	10	33,885,081 (GRCm39)	missense	probably damaging	1.00
R7610:Rwdd1	UTSW	10	33,877,134 (GRCm39)	missense	probably benign	0.00
R8012:Rwdd1	UTSW	10	33,885,198 (GRCm39)	intron	probably benign
R8212:Rwdd1	UTSW	10	33,878,523 (GRCm39)	missense	probably damaging	1.00
R8848:Rwdd1	UTSW	10	33,884,987 (GRCm39)	critical splice donor site	probably null
R8960:Rwdd1	UTSW	10	33,895,383 (GRCm39)	missense	possibly damaging	0.62
R9269:Rwdd1	UTSW	10	33,888,095 (GRCm39)	missense	probably damaging	0.96
R9712:Rwdd1	UTSW	10	33,877,152 (GRCm39)	missense

Posted On

2015-04-16