Incidental Mutation 'R3900:Or4c11b'
ID 308919
Institutional Source Beutler Lab
Gene Symbol Or4c11b
Ensembl Gene ENSMUSG00000059023
Gene Name olfactory receptor family 4 subfamily C member 11B
Synonyms GA_x6K02T2Q125-50268830-50269753, Olfr1201, MOR230-2
MMRRC Submission 041607-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R3900 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88624728-88625651 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88625273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 182 (L182F)
Ref Sequence ENSEMBL: ENSMUSP00000150454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073458] [ENSMUST00000216213]
AlphaFold Q8VGF5
Predicted Effect possibly damaging
Transcript: ENSMUST00000073458
AA Change: L182F

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000073163
Gene: ENSMUSG00000059023
AA Change: L182F

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.4e-46 PFAM
Pfam:7TM_GPCR_Srsx 32 300 3.3e-5 PFAM
Pfam:7tm_1 39 285 3e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214018
Predicted Effect possibly damaging
Transcript: ENSMUST00000216213
AA Change: L182F

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833439L19Rik A T 13: 54,700,781 (GRCm39) S212R probably damaging Het
AI182371 T C 2: 34,975,228 (GRCm39) I334V probably benign Het
Anpep A G 7: 79,488,973 (GRCm39) S372P probably benign Het
Apc2 C A 10: 80,131,806 (GRCm39) probably null Het
Bcl6 T G 16: 23,796,304 (GRCm39) E41A possibly damaging Het
Brpf1 A G 6: 113,295,394 (GRCm39) I674V probably benign Het
Cherp A G 8: 73,223,780 (GRCm39) I201T possibly damaging Het
Cluh A G 11: 74,557,930 (GRCm39) H1056R probably benign Het
Csgalnact2 A T 6: 118,097,975 (GRCm39) F122I probably damaging Het
Cubn C A 2: 13,291,791 (GRCm39) probably null Het
Dnah17 A T 11: 117,985,634 (GRCm39) I1481N possibly damaging Het
Eif2ak4 A G 2: 118,305,510 (GRCm39) Y1561C probably damaging Het
Elfn1 G A 5: 139,957,719 (GRCm39) R241H probably damaging Het
Eml5 G A 12: 98,791,782 (GRCm39) R1245C probably damaging Het
Fchsd2 A G 7: 100,841,006 (GRCm39) K172E possibly damaging Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably null Het
Gm6133 A G 18: 78,393,365 (GRCm39) N120D probably benign Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igsf9 T C 1: 172,317,125 (GRCm39) L35P probably damaging Het
Khdc3 T C 9: 73,011,628 (GRCm39) probably benign Het
Mmrn2 G T 14: 34,121,517 (GRCm39) probably null Het
Mrgpra1 G T 7: 46,985,275 (GRCm39) R135S possibly damaging Het
Or8g2b A G 9: 39,750,698 (GRCm39) probably null Het
Otud3 T C 4: 138,624,196 (GRCm39) N282S probably benign Het
Prkar1a A G 11: 109,551,901 (GRCm39) K130R probably benign Het
Rd3 T C 1: 191,717,217 (GRCm39) V114A probably damaging Het
Rictor T G 15: 6,818,954 (GRCm39) D1392E probably benign Het
Setd2 C T 9: 110,421,586 (GRCm39) R273W probably damaging Het
Slc22a18 C A 7: 143,033,507 (GRCm39) A86E probably damaging Het
Slc24a1 A T 9: 64,835,426 (GRCm39) S900R probably damaging Het
Smarcc1 T C 9: 109,947,586 (GRCm39) probably benign Het
Smoc1 T C 12: 81,214,287 (GRCm39) V234A probably damaging Het
Stard9 A G 2: 120,544,030 (GRCm39) T4443A possibly damaging Het
Timp2 C T 11: 118,194,542 (GRCm39) D139N probably damaging Het
Trim69 A G 2: 122,009,322 (GRCm39) T461A probably benign Het
Ubash3b C T 9: 40,942,860 (GRCm39) D211N probably benign Het
Ubr4 T C 4: 139,206,373 (GRCm39) probably null Het
Ubr5 T C 15: 38,019,486 (GRCm39) D752G probably damaging Het
Urb1 A T 16: 90,580,264 (GRCm39) I633N possibly damaging Het
Usp36 T A 11: 118,170,650 (GRCm39) D28V possibly damaging Het
Wdr6 G A 9: 108,452,968 (GRCm39) A305V probably damaging Het
Zfp248 T C 6: 118,406,527 (GRCm39) N253S probably damaging Het
Other mutations in Or4c11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01082:Or4c11b APN 2 88,625,637 (GRCm39) missense probably benign
IGL02292:Or4c11b APN 2 88,625,631 (GRCm39) missense probably benign
IGL03037:Or4c11b APN 2 88,625,299 (GRCm39) missense probably damaging 1.00
R2341:Or4c11b UTSW 2 88,624,989 (GRCm39) missense probably benign 0.16
R6394:Or4c11b UTSW 2 88,625,296 (GRCm39) missense probably benign 0.22
R7276:Or4c11b UTSW 2 88,625,025 (GRCm39) missense probably damaging 1.00
R9106:Or4c11b UTSW 2 88,625,016 (GRCm39) missense probably benign 0.04
R9654:Or4c11b UTSW 2 88,625,263 (GRCm39) missense probably damaging 1.00
R9802:Or4c11b UTSW 2 88,625,491 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AACCCTTGCGTTACTCAGTC -3'
(R):5'- AAAGTAGTTGGTGGCCGTGC -3'

Sequencing Primer
(F):5'- CGTTACTCAGTCATCATGAGGCG -3'
(R):5'- GTGGCCGTGCATATATGAATATG -3'
Posted On 2015-04-17