Incidental Mutation 'R4517:Tas2r135'
ID |
332946 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tas2r135
|
Ensembl Gene |
ENSMUSG00000056203 |
Gene Name |
taste receptor, type 2, member 135 |
Synonyms |
mt2r38, Tas2r35 |
MMRRC Submission |
041761-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.051)
|
Stock # |
R4517 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
6 |
Chromosomal Location |
42382463-42383428 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 42383013 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Leucine
at position 184
(H184L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000070247
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057398]
[ENSMUST00000070178]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000057398
|
SMART Domains |
Protein: ENSMUSP00000057910 Gene: ENSMUSG00000046652
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
1 |
293 |
6.7e-68 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000070178
AA Change: H184L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000070247 Gene: ENSMUSG00000056203 AA Change: H184L
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
22 |
320 |
1.3e-63 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.6%
|
Validation Efficiency |
95% (39/41) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ank |
A |
G |
15: 27,562,835 (GRCm39) |
H181R |
possibly damaging |
Het |
B4galnt4 |
A |
G |
7: 140,647,635 (GRCm39) |
K408E |
probably damaging |
Het |
Cd209a |
T |
A |
8: 3,795,525 (GRCm39) |
D123V |
probably damaging |
Het |
Cyp4f37 |
A |
G |
17: 32,850,566 (GRCm39) |
I340V |
probably benign |
Het |
Echs1 |
A |
G |
7: 139,692,409 (GRCm39) |
S113P |
possibly damaging |
Het |
Fap |
T |
C |
2: 62,361,059 (GRCm39) |
I391V |
probably benign |
Het |
Glb1l |
C |
T |
1: 75,185,347 (GRCm39) |
C121Y |
probably damaging |
Het |
Glod4 |
T |
A |
11: 76,134,397 (GRCm39) |
D25V |
probably damaging |
Het |
Gpc5 |
T |
A |
14: 115,789,651 (GRCm39) |
N508K |
possibly damaging |
Het |
H2-M10.3 |
C |
T |
17: 36,678,722 (GRCm39) |
|
probably null |
Het |
Ibsp |
C |
A |
5: 104,453,863 (GRCm39) |
S67* |
probably null |
Het |
Ifit1bl2 |
C |
T |
19: 34,607,164 (GRCm39) |
|
probably benign |
Het |
Iqgap2 |
A |
G |
13: 95,800,569 (GRCm39) |
|
probably null |
Het |
Kcnma1 |
A |
G |
14: 23,387,097 (GRCm39) |
S982P |
probably damaging |
Het |
Kif5b |
T |
C |
18: 6,213,272 (GRCm39) |
S707G |
probably benign |
Het |
Lrrk2 |
A |
G |
15: 91,589,323 (GRCm39) |
I437V |
probably benign |
Het |
Mapkbp1 |
T |
C |
2: 119,855,545 (GRCm39) |
|
probably benign |
Het |
Mcu |
T |
C |
10: 59,303,456 (GRCm39) |
Y127C |
probably damaging |
Het |
Mlst8 |
T |
C |
17: 24,695,031 (GRCm39) |
Y284C |
probably damaging |
Het |
Nr2f2 |
T |
G |
7: 70,007,870 (GRCm39) |
N204T |
probably benign |
Het |
Or13a26 |
A |
G |
7: 140,285,004 (GRCm39) |
Y280C |
probably damaging |
Het |
Or7a42 |
T |
A |
10: 78,791,877 (GRCm39) |
Y279* |
probably null |
Het |
Pabir3 |
G |
A |
X: 52,382,376 (GRCm39) |
R94H |
possibly damaging |
Het |
Pcf11 |
T |
C |
7: 92,295,696 (GRCm39) |
Y1451C |
probably damaging |
Het |
Plekhn1 |
T |
C |
4: 156,309,988 (GRCm39) |
S109G |
probably damaging |
Het |
Rttn |
T |
C |
18: 89,047,097 (GRCm39) |
S920P |
probably damaging |
Het |
Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
Tmem38a |
C |
T |
8: 73,326,005 (GRCm39) |
P20S |
possibly damaging |
Het |
Ubqlnl |
C |
T |
7: 103,798,925 (GRCm39) |
V191M |
probably benign |
Het |
Vmn2r102 |
A |
G |
17: 19,901,475 (GRCm39) |
Y534C |
probably damaging |
Het |
Wdr62 |
A |
G |
7: 29,969,683 (GRCm39) |
V259A |
probably damaging |
Het |
Whrn |
A |
G |
4: 63,379,517 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Tas2r135 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01357:Tas2r135
|
APN |
6 |
42,383,078 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01395:Tas2r135
|
APN |
6 |
42,382,846 (GRCm39) |
nonsense |
probably null |
|
IGL02479:Tas2r135
|
APN |
6 |
42,382,685 (GRCm39) |
nonsense |
probably null |
|
IGL02526:Tas2r135
|
APN |
6 |
42,383,214 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02806:Tas2r135
|
APN |
6 |
42,383,382 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02982:Tas2r135
|
APN |
6 |
42,383,187 (GRCm39) |
missense |
probably benign |
|
IGL03057:Tas2r135
|
APN |
6 |
42,378,061 (GRCm39) |
unclassified |
probably benign |
|
R0057:Tas2r135
|
UTSW |
6 |
42,383,354 (GRCm39) |
missense |
probably benign |
0.07 |
R0104:Tas2r135
|
UTSW |
6 |
42,383,258 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1412:Tas2r135
|
UTSW |
6 |
42,382,768 (GRCm39) |
missense |
probably benign |
0.00 |
R4629:Tas2r135
|
UTSW |
6 |
42,383,160 (GRCm39) |
missense |
probably benign |
0.03 |
R5788:Tas2r135
|
UTSW |
6 |
42,382,531 (GRCm39) |
missense |
probably damaging |
1.00 |
R6021:Tas2r135
|
UTSW |
6 |
42,383,321 (GRCm39) |
missense |
probably damaging |
1.00 |
R6586:Tas2r135
|
UTSW |
6 |
42,382,952 (GRCm39) |
missense |
probably benign |
0.18 |
R7180:Tas2r135
|
UTSW |
6 |
42,382,685 (GRCm39) |
nonsense |
probably null |
|
R7458:Tas2r135
|
UTSW |
6 |
42,382,881 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7850:Tas2r135
|
UTSW |
6 |
42,383,072 (GRCm39) |
missense |
probably benign |
|
R9113:Tas2r135
|
UTSW |
6 |
42,383,315 (GRCm39) |
missense |
probably benign |
0.00 |
Z1176:Tas2r135
|
UTSW |
6 |
42,383,168 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- TGACTGCTGCAACCATCTGG -3'
(R):5'- TCCCGAAGTTCTGAAAGGGC -3'
Sequencing Primer
(F):5'- GCTGCAACCATCTGGCTCTG -3'
(R):5'- GGGCCAAGAAAGTCTTCTTCATG -3'
|
Posted On |
2015-08-18 |