Incidental Mutation 'IGL02868:Tas2r107'
| ID |
362412 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r107
|
| Ensembl Gene |
ENSMUSG00000053389 |
| Gene Name |
taste receptor, type 2, member 107 |
| Synonyms |
mGR06, mt2r43, Tas2r7, T2R07, T2R4, STC 5-1 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
IGL02868
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
131636081-131637112 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 131636249 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 267
(T267A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000067082
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000065781]
|
| AlphaFold |
Q7M725 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000065781
AA Change: T267A
PolyPhen 2
Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: T267A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
297 |
4e-106 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgap4 |
A |
G |
X: 72,944,008 (GRCm39) |
I224T |
probably benign |
Het |
| Atp12a |
A |
G |
14: 56,621,639 (GRCm39) |
D758G |
probably damaging |
Het |
| Clca3b |
C |
A |
3: 144,533,325 (GRCm39) |
G569V |
probably damaging |
Het |
| Dlgap4 |
G |
A |
2: 156,542,816 (GRCm39) |
R73Q |
probably damaging |
Het |
| Efcc1 |
C |
T |
6: 87,728,743 (GRCm39) |
|
probably benign |
Het |
| Eno3 |
T |
A |
11: 70,552,826 (GRCm39) |
V369E |
probably damaging |
Het |
| Espl1 |
T |
A |
15: 102,222,425 (GRCm39) |
C1022* |
probably null |
Het |
| Grhl3 |
T |
C |
4: 135,281,915 (GRCm39) |
D319G |
probably damaging |
Het |
| Huwe1 |
G |
A |
X: 150,691,829 (GRCm39) |
R2538H |
possibly damaging |
Het |
| Lrrc37 |
A |
T |
11: 103,505,965 (GRCm39) |
L2001H |
probably benign |
Het |
| Ms4a4d |
T |
A |
19: 11,527,646 (GRCm39) |
I51N |
probably damaging |
Het |
| Mtmr9 |
T |
C |
14: 63,761,588 (GRCm39) |
N522S |
probably benign |
Het |
| Nfe2l1 |
A |
G |
11: 96,710,966 (GRCm39) |
I133T |
probably damaging |
Het |
| Ninl |
A |
G |
2: 150,778,974 (GRCm39) |
Y1296H |
probably benign |
Het |
| Nipal3 |
A |
G |
4: 135,194,182 (GRCm39) |
S284P |
probably damaging |
Het |
| Or4k40 |
A |
T |
2: 111,250,838 (GRCm39) |
F153I |
possibly damaging |
Het |
| Or5g9 |
A |
T |
2: 85,551,919 (GRCm39) |
T57S |
probably benign |
Het |
| Pramel5 |
G |
T |
4: 143,997,922 (GRCm39) |
N440K |
probably benign |
Het |
| Rabep1 |
T |
C |
11: 70,765,572 (GRCm39) |
V12A |
probably benign |
Het |
| Rbm5 |
G |
T |
9: 107,626,899 (GRCm39) |
|
probably benign |
Het |
| Ric3 |
T |
C |
7: 108,653,626 (GRCm39) |
E155G |
probably damaging |
Het |
| Slc12a7 |
T |
A |
13: 73,954,507 (GRCm39) |
M897K |
probably benign |
Het |
| Slc39a8 |
G |
T |
3: 135,561,787 (GRCm39) |
A169S |
probably damaging |
Het |
| Stxbp2 |
A |
T |
8: 3,691,971 (GRCm39) |
I538F |
probably benign |
Het |
| Synrg |
G |
A |
11: 83,877,876 (GRCm39) |
|
probably benign |
Het |
| Tead3 |
G |
T |
17: 28,552,069 (GRCm39) |
Y354* |
probably null |
Het |
| Trim3 |
T |
C |
7: 105,262,239 (GRCm39) |
K579R |
possibly damaging |
Het |
| Uaca |
A |
T |
9: 60,770,919 (GRCm39) |
K362M |
probably damaging |
Het |
| Vmn2r94 |
A |
G |
17: 18,464,316 (GRCm39) |
I658T |
possibly damaging |
Het |
| Vps13b |
C |
T |
15: 35,884,665 (GRCm39) |
P3113S |
probably benign |
Het |
| Zfp251 |
A |
G |
15: 76,738,734 (GRCm39) |
S115P |
probably damaging |
Het |
| Zfp683 |
G |
A |
4: 133,783,177 (GRCm39) |
V214M |
probably benign |
Het |
|
| Other mutations in Tas2r107 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02749:Tas2r107
|
APN |
6 |
131,636,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02751:Tas2r107
|
APN |
6 |
131,636,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02943:Tas2r107
|
APN |
6 |
131,636,369 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1564:Tas2r107
|
UTSW |
6 |
131,636,785 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1905:Tas2r107
|
UTSW |
6 |
131,636,951 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1906:Tas2r107
|
UTSW |
6 |
131,636,951 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1907:Tas2r107
|
UTSW |
6 |
131,636,951 (GRCm39) |
missense |
probably benign |
0.20 |
|
R2185:Tas2r107
|
UTSW |
6 |
131,636,566 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3014:Tas2r107
|
UTSW |
6 |
131,636,972 (GRCm39) |
missense |
probably benign |
0.30 |
|
R3824:Tas2r107
|
UTSW |
6 |
131,636,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4465:Tas2r107
|
UTSW |
6 |
131,636,972 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5058:Tas2r107
|
UTSW |
6 |
131,636,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5646:Tas2r107
|
UTSW |
6 |
131,636,671 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5975:Tas2r107
|
UTSW |
6 |
131,636,743 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6008:Tas2r107
|
UTSW |
6 |
131,636,875 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6144:Tas2r107
|
UTSW |
6 |
131,636,966 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6451:Tas2r107
|
UTSW |
6 |
131,636,977 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6662:Tas2r107
|
UTSW |
6 |
131,636,452 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6702:Tas2r107
|
UTSW |
6 |
131,636,347 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7032:Tas2r107
|
UTSW |
6 |
131,636,153 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7635:Tas2r107
|
UTSW |
6 |
131,636,563 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8303:Tas2r107
|
UTSW |
6 |
131,636,585 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9156:Tas2r107
|
UTSW |
6 |
131,636,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9497:Tas2r107
|
UTSW |
6 |
131,636,549 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9789:Tas2r107
|
UTSW |
6 |
131,636,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-12-18 |
Incidental Mutation