Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02933:Mrgprh'

364192

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprh

Ensembl Gene

ENSMUSG00000059408

Gene Name

MAS-related GPR, member H

Synonyms

Gpr90, MrgH

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL02933

Quality Score

Status

Chromosome

Chromosomal Location

13094921-13096729 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 13096596 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 279 (Y279H)

Ref Sequence

ENSEMBL: ENSMUSP00000074768 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075296]

AlphaFold

Q99MT8

Predicted Effect

probably damaging
Transcript: ENSMUST00000075296
AA Change: Y279H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000074768
Gene: ENSMUSG00000059408
AA Change: Y279H

Domain	Start	End	E-Value	Type
Pfam:7tm_1	51	279	1.1e-12	PFAM
low complexity region	284	295	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700008O03Rik	G	T	7: 44,012,436 (GRCm39)	S24Y	possibly damaging	Het
Adam15	T	C	3: 89,250,790 (GRCm39)	T609A	possibly damaging	Het
Ank1	C	T	8: 23,612,881 (GRCm39)	T1485I	possibly damaging	Het
Bbof1	A	G	12: 84,473,740 (GRCm39)	N357D	probably damaging	Het
Btn1a1	A	G	13: 23,644,697 (GRCm39)	F267S	possibly damaging	Het
C2cd2	A	T	16: 97,693,401 (GRCm39)	F157I	probably benign	Het
Cd55	T	C	1: 130,380,261 (GRCm39)	E239G	probably damaging	Het
Cnpy1	T	A	5: 28,412,119 (GRCm39)	H138L	probably benign	Het
Cpne4	T	C	9: 104,896,966 (GRCm39)	V373A	possibly damaging	Het
Dlg5	A	T	14: 24,208,567 (GRCm39)	S880T	probably benign	Het
Etv1	C	T	12: 38,831,832 (GRCm39)	T27I	probably benign	Het
Fam227b	T	A	2: 125,965,908 (GRCm39)		probably null	Het
Flcn	T	C	11: 59,694,583 (GRCm39)	S130G	probably damaging	Het
Flvcr2	T	C	12: 85,849,902 (GRCm39)		probably benign	Het
Git1	C	A	11: 77,391,902 (GRCm39)	H241Q	probably damaging	Het
Gm14496	T	A	2: 181,642,256 (GRCm39)	H642Q	probably benign	Het
Idh1	C	T	1: 65,201,072 (GRCm39)	S293N	probably damaging	Het
Itpr2	A	G	6: 146,214,402 (GRCm39)	S1449P	probably benign	Het
Mmel1	T	A	4: 154,968,087 (GRCm39)	L141Q	probably damaging	Het
Morn4	A	G	19: 42,064,661 (GRCm39)	I109T	probably benign	Het
Or1ak2	T	A	2: 36,827,310 (GRCm39)	Y60N	probably damaging	Het
Osbpl8	T	C	10: 111,117,991 (GRCm39)	I578T	probably damaging	Het
Reg2	A	G	6: 78,384,917 (GRCm39)	Y153C	probably damaging	Het
Sall2	T	C	14: 52,550,484 (GRCm39)	S902G	probably benign	Het
Sesn3	C	T	9: 14,232,504 (GRCm39)	T259M	probably damaging	Het
Traf1	C	A	2: 34,839,107 (GRCm39)	D73Y	possibly damaging	Het
Trnt1	G	A	6: 106,750,387 (GRCm39)	G97D	probably benign	Het
Ttll11	T	C	2: 35,869,422 (GRCm39)	H72R	probably benign	Het
Txndc12	T	C	4: 108,715,193 (GRCm39)		probably null	Het
Zan	C	A	5: 137,426,676 (GRCm39)	S2490I	unknown	Het
Zfp955a	T	C	17: 33,462,683 (GRCm39)		probably null	Het
Zfyve26	A	C	12: 79,326,854 (GRCm39)	S756R	possibly damaging	Het
Zmynd8	T	C	2: 165,670,238 (GRCm39)	N412S	possibly damaging	Het

Other mutations in Mrgprh

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0358:Mrgprh	UTSW	17	13,096,237 (GRCm39)	missense	probably damaging	1.00
R0373:Mrgprh	UTSW	17	13,095,843 (GRCm39)	missense	possibly damaging	0.90
R1139:Mrgprh	UTSW	17	13,095,829 (GRCm39)	missense	probably benign	0.14
R1934:Mrgprh	UTSW	17	13,095,838 (GRCm39)	missense	probably damaging	0.96
R2169:Mrgprh	UTSW	17	13,095,856 (GRCm39)	missense	probably benign	0.02
R4275:Mrgprh	UTSW	17	13,096,114 (GRCm39)	missense	probably damaging	1.00
R5193:Mrgprh	UTSW	17	13,095,942 (GRCm39)	missense	probably damaging	1.00
R5211:Mrgprh	UTSW	17	13,095,889 (GRCm39)	missense	probably benign	0.02
R5658:Mrgprh	UTSW	17	13,096,646 (GRCm39)	missense	possibly damaging	0.63
R5783:Mrgprh	UTSW	17	13,096,333 (GRCm39)	missense	probably benign	0.06
R6787:Mrgprh	UTSW	17	13,095,874 (GRCm39)	missense	probably benign
R6939:Mrgprh	UTSW	17	13,095,822 (GRCm39)	missense	probably benign	0.00
R8776:Mrgprh	UTSW	17	13,096,375 (GRCm39)	missense	probably benign	0.02
R8776-TAIL:Mrgprh	UTSW	17	13,096,375 (GRCm39)	missense	probably benign	0.02
R9019:Mrgprh	UTSW	17	13,096,200 (GRCm39)	missense	probably damaging	1.00
R9213:Mrgprh	UTSW	17	13,095,917 (GRCm39)	missense	probably damaging	1.00
R9601:Mrgprh	UTSW	17	13,096,264 (GRCm39)	missense	possibly damaging	0.46
Z1177:Mrgprh	UTSW	17	13,096,474 (GRCm39)	missense	probably damaging	0.96

Posted On

2015-12-18