Incidental Mutation 'IGL02950:Ralyl'
ID 364923
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ralyl
Ensembl Gene ENSMUSG00000039717
Gene Name RALY RNA binding protein-like
Synonyms 0710005M24Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # IGL02950
Quality Score
Status
Chromosome 3
Chromosomal Location 13536715-14247347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 14104781 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 15 (N15K)
Ref Sequence ENSEMBL: ENSMUSP00000104009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108372] [ENSMUST00000171075] [ENSMUST00000192209] [ENSMUST00000193117] [ENSMUST00000211860]
AlphaFold Q8BTF8
Predicted Effect probably damaging
Transcript: ENSMUST00000108372
AA Change: N15K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104009
Gene: ENSMUSG00000039717
AA Change: N15K

DomainStartEndE-ValueType
low complexity region 53 69 N/A INTRINSIC
coiled coil region 119 182 N/A INTRINSIC
low complexity region 201 214 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000171075
AA Change: N15K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125848
Gene: ENSMUSG00000039717
AA Change: N15K

DomainStartEndE-ValueType
low complexity region 53 69 N/A INTRINSIC
coiled coil region 119 156 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000192209
AA Change: N15K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000142094
Gene: ENSMUSG00000039717
AA Change: N15K

DomainStartEndE-ValueType
low complexity region 53 69 N/A INTRINSIC
coiled coil region 119 156 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000193117
AA Change: N88K

PolyPhen 2 Score 0.299 (Sensitivity: 0.91; Specificity: 0.89)
Predicted Effect possibly damaging
Transcript: ENSMUST00000211860
AA Change: N102K

PolyPhen 2 Score 0.530 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 A T 19: 43,814,406 (GRCm39) S1129C possibly damaging Het
Afm A T 5: 90,679,466 (GRCm39) D320V probably damaging Het
Ap5m1 C T 14: 49,311,392 (GRCm39) T154I probably benign Het
Bcl11b G A 12: 107,956,065 (GRCm39) T28I probably benign Het
Bhlhe40 G T 6: 108,641,503 (GRCm39) C149F probably damaging Het
Bmper A T 9: 23,310,790 (GRCm39) D408V probably damaging Het
C1rl G A 6: 124,485,820 (GRCm39) C397Y probably damaging Het
C2cd4c A G 10: 79,448,665 (GRCm39) S161P probably damaging Het
Cemip2 A T 19: 21,819,564 (GRCm39) K1118N probably benign Het
Cep290 T C 10: 100,376,191 (GRCm39) probably benign Het
Cp T C 3: 20,042,165 (GRCm39) Y978H probably damaging Het
Csf2ra T C 19: 61,215,607 (GRCm39) D37G probably benign Het
Ddx24 A G 12: 103,383,801 (GRCm39) V596A probably damaging Het
Dnmt3l A G 10: 77,886,785 (GRCm39) S82G probably benign Het
Dock1 A G 7: 134,331,753 (GRCm39) Y46C probably damaging Het
Eno2 A T 6: 124,740,081 (GRCm39) D318E probably damaging Het
Gm43738 A C 3: 88,996,355 (GRCm39) L120R probably damaging Het
Hgsnat C A 8: 26,461,729 (GRCm39) C29F probably damaging Het
Hltf T A 3: 20,130,736 (GRCm39) V318D probably benign Het
Kcnh8 A G 17: 53,263,795 (GRCm39) H764R probably benign Het
Kcnq3 A G 15: 65,892,142 (GRCm39) F411S probably benign Het
Lpcat4 C A 2: 112,074,387 (GRCm39) N287K possibly damaging Het
Ltbp4 A C 7: 27,006,143 (GRCm39) F1512V probably damaging Het
Mctp1 A T 13: 77,172,929 (GRCm39) L868F probably damaging Het
Mdn1 T C 4: 32,713,360 (GRCm39) probably benign Het
Or5g23 A T 2: 85,438,501 (GRCm39) L251Q possibly damaging Het
Otub2 A G 12: 103,369,632 (GRCm39) D237G probably damaging Het
Pax3 A G 1: 78,079,997 (GRCm39) V463A probably benign Het
Podn T C 4: 107,875,048 (GRCm39) K573R possibly damaging Het
Ppp5c A C 7: 16,740,835 (GRCm39) S378A probably benign Het
Pramel29 A G 4: 143,939,531 (GRCm39) V2A probably benign Het
Prl2a1 T A 13: 27,988,914 (GRCm39) L13Q probably damaging Het
Ptgir A G 7: 16,641,526 (GRCm39) T70A probably damaging Het
Rbck1 C T 2: 152,172,997 (GRCm39) R17Q possibly damaging Het
Ryr1 A G 7: 28,796,884 (GRCm39) Y973H probably damaging Het
Sh2d6 A G 6: 72,492,285 (GRCm39) V260A probably damaging Het
Spen G A 4: 141,196,819 (GRCm39) P3559S probably damaging Het
Tbcd T A 11: 121,494,535 (GRCm39) V1032D probably damaging Het
Trav12-1 T A 14: 53,776,024 (GRCm39) V59E probably damaging Het
Unc93a T A 17: 13,344,455 (GRCm39) Q29L probably damaging Het
Zzef1 A G 11: 72,808,525 (GRCm39) probably benign Het
Other mutations in Ralyl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02508:Ralyl APN 3 14,172,332 (GRCm39) splice site probably benign
IGL02626:Ralyl APN 3 13,842,094 (GRCm39) missense probably benign 0.00
PIT4498001:Ralyl UTSW 3 14,172,299 (GRCm39) missense probably damaging 0.99
R0853:Ralyl UTSW 3 14,011,566 (GRCm39) missense probably damaging 1.00
R1061:Ralyl UTSW 3 14,180,761 (GRCm39) missense probably damaging 1.00
R1068:Ralyl UTSW 3 13,841,949 (GRCm39) missense probably damaging 1.00
R1655:Ralyl UTSW 3 14,172,296 (GRCm39) missense probably damaging 1.00
R1796:Ralyl UTSW 3 14,208,493 (GRCm39) missense possibly damaging 0.77
R1838:Ralyl UTSW 3 14,208,472 (GRCm39) missense probably damaging 1.00
R4706:Ralyl UTSW 3 14,104,850 (GRCm39) critical splice donor site probably null
R5505:Ralyl UTSW 3 13,841,980 (GRCm39) missense probably damaging 1.00
R5510:Ralyl UTSW 3 13,842,005 (GRCm39) missense probably damaging 1.00
R6844:Ralyl UTSW 3 13,841,938 (GRCm39) missense probably damaging 1.00
R6919:Ralyl UTSW 3 13,842,091 (GRCm39) missense probably damaging 1.00
R7876:Ralyl UTSW 3 14,104,850 (GRCm39) critical splice donor site probably null
R8297:Ralyl UTSW 3 14,104,836 (GRCm39) missense probably benign 0.33
R9292:Ralyl UTSW 3 14,172,312 (GRCm39) missense probably benign 0.06
R9686:Ralyl UTSW 3 13,841,887 (GRCm39) splice site probably benign
Posted On 2015-12-18