Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03146:Trgv3'

410903

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trgv3

Ensembl Gene

ENSMUSG00000076750

Gene Name

T cell receptor gamma, variable 3

Synonyms

vgamma3, Tcrg-V3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL03146

Quality Score

Status

Chromosome

Chromosomal Location

19427015-19427471 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 19427337 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 73 (Y73*)

Ref Sequence

ENSEMBL: ENSMUSP00000142927 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103559] [ENSMUST00000198663]

AlphaFold

A0A075B5Z1

Predicted Effect

probably null
Transcript: ENSMUST00000103559
AA Change: Y72*

SMART Domains

Protein: ENSMUSP00000100339
Gene: ENSMUSG00000076750
AA Change: Y72*

Domain	Start	End	E-Value	Type
IGv	34	114	4.92e-12	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000198663
AA Change: Y73*

SMART Domains

Protein: ENSMUSP00000142927
Gene: ENSMUSG00000076750
AA Change: Y73*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
IGv	35	115	2e-14	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	T	C	8: 25,294,519 (GRCm39)	D360G	probably damaging	Het
Adam6a	A	T	12: 113,509,144 (GRCm39)	T506S	probably damaging	Het
Adamts15	A	G	9: 30,832,863 (GRCm39)	V224A	probably damaging	Het
Arhgef12	G	T	9: 42,885,866 (GRCm39)	D1251E	possibly damaging	Het
Ccdc180	G	T	4: 45,903,840 (GRCm39)		probably benign	Het
Ccdc85c	G	A	12: 108,173,395 (GRCm39)	R387*	probably null	Het
Cfap57	T	A	4: 118,456,216 (GRCm39)	I493F	probably damaging	Het
Chst9	A	G	18: 15,586,035 (GRCm39)	I176T	probably damaging	Het
Clpx	G	T	9: 65,234,112 (GRCm39)	V572L	probably benign	Het
Csmd3	T	A	15: 47,744,873 (GRCm39)	N1374I	probably benign	Het
Cyp2e1	T	A	7: 140,350,134 (GRCm39)	M273K	probably benign	Het
Ehbp1l1	T	C	19: 5,770,061 (GRCm39)	E414G	probably benign	Het
Ehd1	T	C	19: 6,327,368 (GRCm39)	F122L	probably damaging	Het
Fcho1	A	G	8: 72,170,074 (GRCm39)		probably benign	Het
Fermt3	T	C	19: 6,980,631 (GRCm39)	E312G	possibly damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
G3bp2	G	A	5: 92,214,399 (GRCm39)	R132C	probably damaging	Het
Inpp4b	A	T	8: 82,470,410 (GRCm39)	I35F	possibly damaging	Het
Izumo3	T	G	4: 92,033,276 (GRCm39)	I107L	probably damaging	Het
Lama3	C	A	18: 12,660,681 (GRCm39)	Q484K	possibly damaging	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Mapkbp1	T	C	2: 119,828,955 (GRCm39)		probably benign	Het
Mast4	T	C	13: 102,874,163 (GRCm39)	N1735S	probably benign	Het
Or14a257	T	C	7: 86,138,402 (GRCm39)	D119G	probably damaging	Het
Or4c100	T	A	2: 88,356,488 (GRCm39)	M187K	possibly damaging	Het
Oxct1	T	C	15: 4,130,630 (GRCm39)	L374P	probably damaging	Het
Parp14	G	A	16: 35,678,823 (GRCm39)	Q382*	probably null	Het
Pax2	A	G	19: 44,821,714 (GRCm39)		probably benign	Het
Prkaa1	T	C	15: 5,198,122 (GRCm39)	V146A	probably damaging	Het
Ptprb	C	T	10: 116,164,032 (GRCm39)	A900V	probably benign	Het
Rgs6	A	T	12: 83,099,312 (GRCm39)	D130V	probably damaging	Het
Ryr1	C	A	7: 28,793,457 (GRCm39)	R1344L	probably benign	Het
Scgb1b12	C	A	7: 32,033,969 (GRCm39)	D76E	possibly damaging	Het
Sel1l3	T	A	5: 53,311,585 (GRCm39)	E633D	probably benign	Het
Slc1a7	T	A	4: 107,850,189 (GRCm39)	I100N	probably damaging	Het
Slc25a35	A	G	11: 68,859,678 (GRCm39)	K64E	possibly damaging	Het
Spmip4	A	T	6: 50,550,853 (GRCm39)	V532E	probably damaging	Het
Stil	C	A	4: 114,881,612 (GRCm39)	Q719K	probably damaging	Het
Stim1	T	A	7: 102,070,562 (GRCm39)	L265Q	probably damaging	Het
Tmem191	A	G	16: 17,095,246 (GRCm39)	E169G	probably damaging	Het
Tmem255b	T	C	8: 13,504,174 (GRCm39)	L101P	probably damaging	Het
Zfyve26	G	A	12: 79,330,846 (GRCm39)	Q458*	probably null	Het

Other mutations in Trgv3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Trgv3	APN	13	19,427,381 (GRCm39)	missense	probably benign	0.44
IGL02458:Trgv3	APN	13	19,427,423 (GRCm39)	missense	probably damaging	0.99
R6777:Trgv3	UTSW	13	19,427,450 (GRCm39)	missense	probably damaging	1.00
R7275:Trgv3	UTSW	13	19,427,188 (GRCm39)	missense	probably benign	0.20
R7491:Trgv3	UTSW	13	19,427,016 (GRCm39)	start codon destroyed	probably null	0.99
R8434:Trgv3	UTSW	13	19,427,036 (GRCm39)	missense	probably benign
R8965:Trgv3	UTSW	13	19,427,180 (GRCm39)	missense	probably damaging	1.00
R9307:Trgv3	UTSW	13	19,427,441 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02