Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03152:Kif23'

411138

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Kif23

Ensembl Gene

ENSMUSG00000032254

Gene Name

kinesin family member 23

Synonyms

Knsl5, CHO1, C87313, MKLP-1, 3110001D19Rik, MKLP1

Accession Numbers

Essential gene?

Probably essential (E-score: 0.972) question?

Stock #

IGL03152

Quality Score

Status

Chromosome

Chromosomal Location

61824559-61854078 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 61837058 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149553 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034815] [ENSMUST00000214295]

AlphaFold

E9Q5G3

Predicted Effect

probably benign
Transcript: ENSMUST00000034815

SMART Domains

Protein: ENSMUSP00000034815
Gene: ENSMUSG00000032254

Domain	Start	End	E-Value	Type
KISc	23	444	6.56e-147	SMART
Blast:KISc	524	607	8e-20	BLAST
low complexity region	661	678	N/A	INTRINSIC
low complexity region	681	693	N/A	INTRINSIC
low complexity region	715	728	N/A	INTRINSIC
Pfam:MKLP1_Arf_bdg	796	899	9.2e-47	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213595

Predicted Effect

probably benign
Transcript: ENSMUST00000214295

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214940

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215965

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216717

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216746

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216812

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cacna2d1	T	A	5: 16,527,566 (GRCm39)	N540K	probably benign	Het
Caln1	A	G	5: 130,646,693 (GRCm39)	E43G	probably damaging	Het
Car14	A	C	3: 95,806,157 (GRCm39)	C301W	probably damaging	Het
Clpx	G	A	9: 65,217,458 (GRCm39)	V9I	possibly damaging	Het
Edar	A	G	10: 58,445,817 (GRCm39)	F249S	possibly damaging	Het
Fads2b	A	G	2: 85,330,648 (GRCm39)	S220P	probably damaging	Het
Fhip2a	C	A	19: 57,367,264 (GRCm39)	T269K	probably damaging	Het
Gm4799	A	G	10: 82,790,797 (GRCm39)		noncoding transcript	Het
Grk4	T	C	5: 34,902,701 (GRCm39)	S418P	probably damaging	Het
Kcnh4	A	G	11: 100,636,598 (GRCm39)	S774P	probably benign	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Myef2l	A	T	3: 10,153,334 (GRCm39)	K34N	probably benign	Het
Or5al1	A	T	2: 85,990,030 (GRCm39)	I228N	possibly damaging	Het
Pcgf6	A	T	19: 47,037,344 (GRCm39)		probably benign	Het
Ryr2	G	A	13: 11,868,036 (GRCm39)	R265C	probably damaging	Het
Smgc	A	G	15: 91,725,625 (GRCm39)	K2R	possibly damaging	Het
Stx5a	T	C	19: 8,727,138 (GRCm39)		probably null	Het
Syne2	A	T	12: 76,012,486 (GRCm39)	N2560I	probably benign	Het
Tuba3a	A	T	6: 125,258,300 (GRCm39)	L230Q	probably damaging	Het
Tubb4b-ps1	A	G	5: 7,230,001 (GRCm39)		probably benign	Het
Zfp217	A	G	2: 169,960,972 (GRCm39)	S452P	probably damaging	Het
Zfp764l1	A	G	7: 126,991,469 (GRCm39)	C173R	probably damaging	Het
Zzef1	G	A	11: 72,814,008 (GRCm39)		probably null	Het

Other mutations in Kif23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00428:Kif23	APN	9	61,833,750 (GRCm39)	missense	probably benign	0.19
IGL00814:Kif23	APN	9	61,844,389 (GRCm39)	missense	possibly damaging	0.95
IGL01295:Kif23	APN	9	61,839,411 (GRCm39)	missense	possibly damaging	0.89
IGL01521:Kif23	APN	9	61,827,182 (GRCm39)	missense	probably damaging	0.99
IGL01583:Kif23	APN	9	61,842,750 (GRCm39)	missense	probably damaging	1.00
IGL01680:Kif23	APN	9	61,839,096 (GRCm39)	missense	probably benign	0.17
IGL02450:Kif23	APN	9	61,831,239 (GRCm39)	missense	probably benign	0.00
IGL02698:Kif23	APN	9	61,832,283 (GRCm39)	missense	possibly damaging	0.49
IGL03233:Kif23	APN	9	61,833,735 (GRCm39)	missense	probably benign	0.05
H8562:Kif23	UTSW	9	61,831,347 (GRCm39)	missense	probably benign
R0225:Kif23	UTSW	9	61,832,976 (GRCm39)	splice site	probably benign
R0419:Kif23	UTSW	9	61,833,687 (GRCm39)	nonsense	probably null
R0512:Kif23	UTSW	9	61,826,257 (GRCm39)	splice site	probably benign
R0731:Kif23	UTSW	9	61,832,314 (GRCm39)	missense	possibly damaging	0.67
R0980:Kif23	UTSW	9	61,844,046 (GRCm39)	missense	possibly damaging	0.93
R1315:Kif23	UTSW	9	61,831,270 (GRCm39)	splice site	probably null
R1347:Kif23	UTSW	9	61,834,438 (GRCm39)	missense	probably damaging	0.99
R1347:Kif23	UTSW	9	61,834,438 (GRCm39)	missense	probably damaging	0.99
R1451:Kif23	UTSW	9	61,832,084 (GRCm39)	missense	probably damaging	1.00
R1624:Kif23	UTSW	9	61,832,982 (GRCm39)	splice site	probably null
R1820:Kif23	UTSW	9	61,833,720 (GRCm39)	missense	possibly damaging	0.67
R1867:Kif23	UTSW	9	61,826,243 (GRCm39)	missense	possibly damaging	0.87
R1937:Kif23	UTSW	9	61,853,892 (GRCm39)	critical splice donor site	probably null
R2001:Kif23	UTSW	9	61,834,666 (GRCm39)	nonsense	probably null
R2002:Kif23	UTSW	9	61,834,666 (GRCm39)	nonsense	probably null
R2310:Kif23	UTSW	9	61,831,426 (GRCm39)	missense	probably damaging	1.00
R2680:Kif23	UTSW	9	61,844,758 (GRCm39)	missense	probably benign	0.25
R3196:Kif23	UTSW	9	61,839,193 (GRCm39)	nonsense	probably null
R3774:Kif23	UTSW	9	61,832,274 (GRCm39)	missense	probably benign	0.00
R3775:Kif23	UTSW	9	61,832,274 (GRCm39)	missense	probably benign	0.00
R3776:Kif23	UTSW	9	61,832,274 (GRCm39)	missense	probably benign	0.00
R4349:Kif23	UTSW	9	61,839,396 (GRCm39)	missense	probably damaging	1.00
R4671:Kif23	UTSW	9	61,852,641 (GRCm39)	missense	probably benign	0.04
R4981:Kif23	UTSW	9	61,839,153 (GRCm39)	missense	probably damaging	1.00
R4983:Kif23	UTSW	9	61,843,985 (GRCm39)	missense	probably benign	0.01
R5685:Kif23	UTSW	9	61,852,691 (GRCm39)	missense	probably benign	0.12
R5721:Kif23	UTSW	9	61,851,498 (GRCm39)	missense	probably benign	0.45
R6903:Kif23	UTSW	9	61,834,436 (GRCm39)	missense	possibly damaging	0.77
R7067:Kif23	UTSW	9	61,832,271 (GRCm39)	missense	probably benign	0.01
R7103:Kif23	UTSW	9	61,827,174 (GRCm39)	missense	probably damaging	0.99
R7456:Kif23	UTSW	9	61,844,402 (GRCm39)	missense	probably benign	0.09
R7468:Kif23	UTSW	9	61,844,457 (GRCm39)	nonsense	probably null
R8357:Kif23	UTSW	9	61,834,317 (GRCm39)	critical splice donor site	probably null
R8457:Kif23	UTSW	9	61,834,317 (GRCm39)	critical splice donor site	probably null
R8716:Kif23	UTSW	9	61,844,477 (GRCm39)	missense	probably damaging	1.00
R8783:Kif23	UTSW	9	61,834,853 (GRCm39)	missense	probably benign	0.00
R9028:Kif23	UTSW	9	61,828,341 (GRCm39)	missense	probably damaging	0.99
R9137:Kif23	UTSW	9	61,834,713 (GRCm39)	missense	probably damaging	0.97
R9283:Kif23	UTSW	9	61,852,651 (GRCm39)	missense	probably benign
R9430:Kif23	UTSW	9	61,834,722 (GRCm39)	missense	probably damaging	1.00
R9457:Kif23	UTSW	9	61,851,507 (GRCm39)	missense	probably benign	0.02
R9533:Kif23	UTSW	9	61,832,924 (GRCm39)	missense	probably benign
Z1177:Kif23	UTSW	9	61,831,445 (GRCm39)	missense	possibly damaging	0.93

Posted On

2016-08-02