Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03219:Cyp2c67'

413584

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c67

Ensembl Gene

ENSMUSG00000062624

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 67

Synonyms

C730004C24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL03219

Quality Score

Status

Chromosome

Chromosomal Location

39597288-39637497 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 39631738 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 153 (M153K)

Ref Sequence

ENSEMBL: ENSMUSP00000065796 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067328]

AlphaFold

Q569X9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000067328
AA Change: M153K

PolyPhen 2 Score 0.539 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624
AA Change: M153K

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	8.5e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Clasp2	T	C	9: 113,677,545 (GRCm39)		probably benign	Het
Ctss	C	T	3: 95,450,411 (GRCm39)	R121W	possibly damaging	Het
Cyp2d34	T	C	15: 82,502,740 (GRCm39)	H162R	probably benign	Het
Dynlrb2	A	T	8: 117,241,635 (GRCm39)	I60F	probably benign	Het
E4f1	C	T	17: 24,664,419 (GRCm39)		probably null	Het
Fzd6	T	A	15: 38,894,971 (GRCm39)	V379E	probably damaging	Het
Galnt13	T	C	2: 54,823,447 (GRCm39)	V341A	possibly damaging	Het
Hip1	T	C	5: 135,485,904 (GRCm39)	S100G	probably benign	Het
Ncapd3	T	C	9: 26,975,169 (GRCm39)		probably benign	Het
Obox3	G	A	7: 15,359,803 (GRCm39)	L289F	probably damaging	Het
Or52s6	C	T	7: 103,091,745 (GRCm39)	G195E	possibly damaging	Het
Or8b50	G	T	9: 38,518,247 (GRCm39)	C162F	probably benign	Het
Pkhd1l1	G	A	15: 44,460,291 (GRCm39)	E4167K	possibly damaging	Het
Pphln1	T	C	15: 93,363,136 (GRCm39)		probably benign	Het
Ranbp6	A	T	19: 29,787,680 (GRCm39)	W891R	probably damaging	Het
Rgs22	A	T	15: 36,107,194 (GRCm39)	L64Q	probably damaging	Het
Ripor2	A	T	13: 24,907,702 (GRCm39)	Y991F	probably damaging	Het
Senp2	T	A	16: 21,833,014 (GRCm39)		probably benign	Het
Slc44a3	G	A	3: 121,257,169 (GRCm39)	T508I	probably damaging	Het
Tdrd6	T	C	17: 43,938,855 (GRCm39)	D731G	probably benign	Het
Thnsl1	T	A	2: 21,217,217 (GRCm39)	C324S	probably benign	Het
Tnfrsf11b	A	T	15: 54,117,574 (GRCm39)	L227*	probably null	Het
Tulp4	T	C	17: 6,189,285 (GRCm39)	C36R	probably damaging	Het

Other mutations in Cyp2c67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Cyp2c67	APN	19	39,631,829 (GRCm39)	missense	possibly damaging	0.95
IGL01025:Cyp2c67	APN	19	39,628,376 (GRCm39)	nonsense	probably null
IGL01363:Cyp2c67	APN	19	39,628,411 (GRCm39)	missense	probably damaging	0.99
IGL01819:Cyp2c67	APN	19	39,604,165 (GRCm39)	missense	probably damaging	0.98
IGL01902:Cyp2c67	APN	19	39,637,470 (GRCm39)	missense	probably damaging	1.00
IGL02172:Cyp2c67	APN	19	39,637,446 (GRCm39)	missense	possibly damaging	0.76
IGL02351:Cyp2c67	APN	19	39,605,861 (GRCm39)	missense	probably damaging	1.00
IGL02355:Cyp2c67	APN	19	39,605,826 (GRCm39)	nonsense	probably null
IGL02355:Cyp2c67	APN	19	39,631,849 (GRCm39)	missense	probably benign	0.34
IGL02358:Cyp2c67	APN	19	39,605,861 (GRCm39)	missense	probably damaging	1.00
IGL02362:Cyp2c67	APN	19	39,605,826 (GRCm39)	nonsense	probably null
IGL02362:Cyp2c67	APN	19	39,631,849 (GRCm39)	missense	probably benign	0.34
IGL02388:Cyp2c67	APN	19	39,631,799 (GRCm39)	missense	probably benign	0.20
IGL03106:Cyp2c67	APN	19	39,632,119 (GRCm39)	missense	probably benign	0.27
IGL03326:Cyp2c67	APN	19	39,631,713 (GRCm39)	critical splice donor site	probably null
IGL03349:Cyp2c67	APN	19	39,632,128 (GRCm39)	missense	probably damaging	1.00
IGL03356:Cyp2c67	APN	19	39,628,405 (GRCm39)	missense	probably damaging	1.00
IGL03052:Cyp2c67	UTSW	19	39,637,329 (GRCm39)	missense	possibly damaging	0.88
R0585:Cyp2c67	UTSW	19	39,627,138 (GRCm39)	missense	possibly damaging	0.59
R0975:Cyp2c67	UTSW	19	39,597,622 (GRCm39)	missense	possibly damaging	0.49
R0976:Cyp2c67	UTSW	19	39,631,818 (GRCm39)	missense	probably damaging	1.00
R1252:Cyp2c67	UTSW	19	39,614,585 (GRCm39)	missense	possibly damaging	0.93
R1398:Cyp2c67	UTSW	19	39,627,069 (GRCm39)	missense	probably damaging	0.96
R1411:Cyp2c67	UTSW	19	39,627,035 (GRCm39)	missense	probably damaging	1.00
R1505:Cyp2c67	UTSW	19	39,637,408 (GRCm39)	missense	probably benign	0.00
R1543:Cyp2c67	UTSW	19	39,631,708 (GRCm39)	splice site	probably benign
R1613:Cyp2c67	UTSW	19	39,614,643 (GRCm39)	missense	probably benign	0.00
R1618:Cyp2c67	UTSW	19	39,631,708 (GRCm39)	splice site	probably benign
R1667:Cyp2c67	UTSW	19	39,632,034 (GRCm39)	critical splice donor site	probably null
R1852:Cyp2c67	UTSW	19	39,605,811 (GRCm39)	missense	probably benign	0.01
R2005:Cyp2c67	UTSW	19	39,631,789 (GRCm39)	missense	probably damaging	1.00
R2105:Cyp2c67	UTSW	19	39,614,681 (GRCm39)	missense	probably benign	0.24
R2181:Cyp2c67	UTSW	19	39,597,541 (GRCm39)	missense	possibly damaging	0.94
R3817:Cyp2c67	UTSW	19	39,627,127 (GRCm39)	missense	probably benign	0.00
R4669:Cyp2c67	UTSW	19	39,632,098 (GRCm39)	missense	probably benign	0.00
R4689:Cyp2c67	UTSW	19	39,627,032 (GRCm39)	missense	probably benign	0.00
R4756:Cyp2c67	UTSW	19	39,632,188 (GRCm39)	missense	probably benign	0.03
R4823:Cyp2c67	UTSW	19	39,604,168 (GRCm39)	missense	probably benign	0.13
R5152:Cyp2c67	UTSW	19	39,627,132 (GRCm39)	missense	probably benign	0.00
R5345:Cyp2c67	UTSW	19	39,614,676 (GRCm39)	missense	probably benign	0.01
R5580:Cyp2c67	UTSW	19	39,604,094 (GRCm39)	missense	probably damaging	0.99
R5644:Cyp2c67	UTSW	19	39,604,138 (GRCm39)	missense	possibly damaging	0.84
R6116:Cyp2c67	UTSW	19	39,605,879 (GRCm39)	missense	probably damaging	1.00
R6516:Cyp2c67	UTSW	19	39,605,873 (GRCm39)	missense	probably damaging	1.00
R6550:Cyp2c67	UTSW	19	39,605,854 (GRCm39)	nonsense	probably null
R6939:Cyp2c67	UTSW	19	39,631,778 (GRCm39)	missense	possibly damaging	0.68
R6995:Cyp2c67	UTSW	19	39,604,123 (GRCm39)	missense	probably damaging	0.96
R7028:Cyp2c67	UTSW	19	39,628,341 (GRCm39)	missense	possibly damaging	0.68
R7144:Cyp2c67	UTSW	19	39,604,138 (GRCm39)	missense	probably benign	0.00
R7242:Cyp2c67	UTSW	19	39,605,783 (GRCm39)	missense	probably benign	0.30
R7335:Cyp2c67	UTSW	19	39,628,451 (GRCm39)	nonsense	probably null
R7337:Cyp2c67	UTSW	19	39,597,708 (GRCm39)	splice site	probably null
R7474:Cyp2c67	UTSW	19	39,605,876 (GRCm39)	missense	probably null	0.05
R7642:Cyp2c67	UTSW	19	39,604,084 (GRCm39)	missense	probably damaging	0.97
R7870:Cyp2c67	UTSW	19	39,597,669 (GRCm39)	missense	probably damaging	1.00
R8152:Cyp2c67	UTSW	19	39,628,452 (GRCm39)	missense	probably benign	0.21
R8367:Cyp2c67	UTSW	19	39,627,118 (GRCm39)	missense	probably benign	0.01
R8717:Cyp2c67	UTSW	19	39,627,155 (GRCm39)	missense	probably benign	0.05
R8728:Cyp2c67	UTSW	19	39,614,605 (GRCm39)	missense	probably damaging	1.00
R9275:Cyp2c67	UTSW	19	39,597,699 (GRCm39)	missense	probably damaging	1.00
R9278:Cyp2c67	UTSW	19	39,597,699 (GRCm39)	missense	probably damaging	1.00
R9376:Cyp2c67	UTSW	19	39,627,178 (GRCm39)	missense	probably damaging	1.00
Z1177:Cyp2c67	UTSW	19	39,632,123 (GRCm39)	missense	possibly damaging	0.89

Posted On

2016-08-02