Incidental Mutation 'IGL03302:Ccl24'
ID 416253
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccl24
Ensembl Gene ENSMUSG00000004814
Gene Name C-C motif chemokine ligand 24
Synonyms MPIF-2, CKb-6, Scya24, eotaxin-2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03302
Quality Score
Status
Chromosome 5
Chromosomal Location 135598791-135601903 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 135599732 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 93 (K93E)
Ref Sequence ENSEMBL: ENSMUSP00000144002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004936] [ENSMUST00000201401]
AlphaFold Q9JKC0
Predicted Effect probably benign
Transcript: ENSMUST00000004936
AA Change: K93E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000004936
Gene: ENSMUSG00000004814
AA Change: K93E

DomainStartEndE-ValueType
low complexity region 8 20 N/A INTRINSIC
SCY 30 89 3.57e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000201401
AA Change: K93E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000144002
Gene: ENSMUSG00000004814
AA Change: K93E

DomainStartEndE-ValueType
low complexity region 8 20 N/A INTRINSIC
SCY 30 89 3.57e-24 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutant mice are born at the expected Mendelian frequency and appear healthy and normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,858,576 (GRCm39) Y542F possibly damaging Het
Ankrd34b A T 13: 92,576,151 (GRCm39) N461I possibly damaging Het
Ccr9 T A 9: 123,608,601 (GRCm39) D94E probably damaging Het
Cd79a G A 7: 24,598,759 (GRCm39) V103M probably damaging Het
Ces1e A G 8: 93,950,521 (GRCm39) probably null Het
Cul9 T C 17: 46,837,566 (GRCm39) E993G probably damaging Het
Cyp4a14 T C 4: 115,348,575 (GRCm39) I330V probably benign Het
Cyp7a1 T C 4: 6,273,801 (GRCm39) D35G probably benign Het
Dmpk C A 7: 18,820,411 (GRCm39) probably benign Het
Gcnt1 G T 19: 17,306,547 (GRCm39) R393S probably benign Het
Lctl C T 9: 64,042,130 (GRCm39) probably benign Het
Mttp A T 3: 137,810,468 (GRCm39) I664N possibly damaging Het
Myh1 C T 11: 67,102,328 (GRCm39) A873V probably benign Het
Nedd9 A G 13: 41,492,330 (GRCm39) V54A probably damaging Het
Or3a1b T G 11: 74,012,459 (GRCm39) C115G possibly damaging Het
Or4f14 A T 2: 111,743,167 (GRCm39) V36E possibly damaging Het
Or6b1 G T 6: 42,814,937 (GRCm39) E41* probably null Het
Pak6 A T 2: 118,523,784 (GRCm39) E313V probably benign Het
Pla2g4a A G 1: 149,740,698 (GRCm39) S402P probably benign Het
Polq T C 16: 36,892,134 (GRCm39) M2012T probably damaging Het
Ppp1r12b A T 1: 134,765,788 (GRCm39) probably benign Het
Rbp3 A G 14: 33,676,616 (GRCm39) H188R probably damaging Het
Rps6ka2 C A 17: 7,566,787 (GRCm39) Q682K possibly damaging Het
Scgb2b7 A T 7: 31,404,506 (GRCm39) C65S probably damaging Het
Spag4 A G 2: 155,910,340 (GRCm39) Q322R probably damaging Het
Spef2 T C 15: 9,676,466 (GRCm39) T702A probably benign Het
Spmap2l T G 5: 77,202,423 (GRCm39) S281R probably benign Het
Taf3 G T 2: 9,956,942 (GRCm39) F408L probably damaging Het
Tead2 T G 7: 44,882,323 (GRCm39) Y121D possibly damaging Het
Tmco5 A T 2: 116,722,760 (GRCm39) T294S probably damaging Het
Trim37 A G 11: 87,037,827 (GRCm39) E187G possibly damaging Het
Ubb T A 11: 62,443,243 (GRCm39) L91Q probably damaging Het
Ugt2a3 G A 5: 87,484,439 (GRCm39) P195L probably damaging Het
Zan T C 5: 137,466,652 (GRCm39) S402G possibly damaging Het
Zc3h7a T A 16: 10,959,574 (GRCm39) H793L probably damaging Het
Zfhx4 C T 3: 5,468,773 (GRCm39) T2977I possibly damaging Het
Other mutations in Ccl24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4779:Ccl24 UTSW 5 135,601,811 (GRCm39) missense possibly damaging 0.74
R5139:Ccl24 UTSW 5 135,601,775 (GRCm39) missense probably benign 0.02
R7391:Ccl24 UTSW 5 135,599,676 (GRCm39) missense possibly damaging 0.67
Posted On 2016-08-02