Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03084:Lrrc69'

417996

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc69

Ensembl Gene

ENSMUSG00000023151

Gene Name

leucine rich repeat containing 69

Synonyms

1700034K16Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL03084

Quality Score

Status

Chromosome

Chromosomal Location

14623620-14796060 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 14708631 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 238 (P238S)

Ref Sequence

ENSEMBL: ENSMUSP00000103911 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023917] [ENSMUST00000108276]

AlphaFold

Q9D9Q0

Predicted Effect

probably damaging
Transcript: ENSMUST00000023917
AA Change: P238S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000023917
Gene: ENSMUSG00000023151
AA Change: P238S

Domain	Start	End	E-Value	Type
LRR	36	58	4.57e0	SMART
LRR	59	81	2.82e0	SMART
LRR	82	105	7.55e-1	SMART
LRR	106	128	7.79e0	SMART
LRR	129	151	1.99e0	SMART
LRR	152	174	5.72e0	SMART
LRR	175	197	3.86e0	SMART
LRR	198	220	8.24e0	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000108276
AA Change: P238S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000103911
Gene: ENSMUSG00000023151
AA Change: P238S

Domain	Start	End	E-Value	Type
LRR	36	58	4.57e0	SMART
LRR	59	81	2.82e0	SMART
LRR	82	105	7.55e-1	SMART
LRR	106	128	7.79e0	SMART
LRR	129	151	1.99e0	SMART
LRR	152	174	5.72e0	SMART
LRR	175	197	3.86e0	SMART
LRR	198	220	8.24e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143565

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars1	G	T	8: 111,768,261 (GRCm39)	V211L	probably damaging	Het
BC024139	T	C	15: 76,004,007 (GRCm39)	D753G	probably benign	Het
Brpf3	A	G	17: 29,054,751 (GRCm39)	M1098V	probably damaging	Het
Cachd1	T	A	4: 100,860,285 (GRCm39)	D1285E	probably damaging	Het
Cacna1b	T	C	2: 24,499,944 (GRCm39)	T147A	probably benign	Het
Cdc14a	A	G	3: 116,142,101 (GRCm39)		probably null	Het
Cfhr4	T	A	1: 139,708,880 (GRCm39)	L9F	possibly damaging	Het
Chd1	A	G	17: 15,990,560 (GRCm39)	H1704R	probably benign	Het
Dmkn	T	G	7: 30,470,481 (GRCm39)	N367K	possibly damaging	Het
Fam151b	C	A	13: 92,604,534 (GRCm39)	D152Y	probably damaging	Het
Gabrg3	T	C	7: 56,384,812 (GRCm39)	S250G	possibly damaging	Het
Gm28042	A	G	2: 119,870,986 (GRCm39)	Q833R	probably benign	Het
Gnpat	A	C	8: 125,605,638 (GRCm39)	Y336S	probably damaging	Het
Ighv1-54	G	A	12: 115,157,736 (GRCm39)		probably benign	Het
Irag1	A	G	7: 110,485,036 (GRCm39)		probably benign	Het
Kif2c	T	C	4: 117,035,355 (GRCm39)	N31S	possibly damaging	Het
Larp1	T	A	11: 57,947,921 (GRCm39)	L939Q	probably damaging	Het
Lypd10	T	C	7: 24,413,605 (GRCm39)	I207T	possibly damaging	Het
Lztfl1	C	T	9: 123,538,641 (GRCm39)	G152E	probably damaging	Het
Man2a2	T	C	7: 80,002,691 (GRCm39)	T1097A	possibly damaging	Het
Myh4	A	G	11: 67,142,777 (GRCm39)		probably null	Het
Nab2	C	T	10: 127,500,346 (GRCm39)	V249M	probably damaging	Het
Nid2	A	T	14: 19,819,000 (GRCm39)	D498V	probably benign	Het
Nrap	T	C	19: 56,353,886 (GRCm39)	T404A	probably damaging	Het
Or51i1	A	G	7: 103,670,838 (GRCm39)	V229A	probably benign	Het
Or5al7	A	T	2: 85,992,569 (GRCm39)	C241*	probably null	Het
Or5c1	T	C	2: 37,222,413 (GRCm39)	I218T	probably damaging	Het
Or8c9	T	G	9: 38,241,513 (GRCm39)	I210S	probably damaging	Het
Pard3	A	G	8: 128,319,573 (GRCm39)	I1104V	probably damaging	Het
Pcna	C	T	2: 132,093,673 (GRCm39)	E109K	probably benign	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Ppfia3	A	G	7: 44,989,651 (GRCm39)	V1187A	probably benign	Het
Ppp1r16b	G	A	2: 158,603,413 (GRCm39)	W346*	probably null	Het
Rpl4	A	G	9: 64,085,599 (GRCm39)		probably benign	Het
Scn8a	A	T	15: 100,915,053 (GRCm39)	I1206F	probably damaging	Het
Slc5a2	T	C	7: 127,865,776 (GRCm39)	S61P	probably benign	Het
Smarcal1	T	C	1: 72,638,094 (GRCm39)		probably null	Het
Smyd4	A	G	11: 75,281,433 (GRCm39)	H302R	probably benign	Het
Sntb1	A	G	15: 55,655,487 (GRCm39)	I243T	probably damaging	Het
Stx8	C	T	11: 67,911,782 (GRCm39)	Q167*	probably null	Het
Sycp2	C	A	2: 178,033,584 (GRCm39)		probably benign	Het
Ttn	A	T	2: 76,626,742 (GRCm39)	V13088D	probably damaging	Het
Ugt2b1	T	A	5: 87,074,243 (GRCm39)	M39L	probably benign	Het
Utp6	A	T	11: 79,853,042 (GRCm39)		probably null	Het
Vmn1r189	A	T	13: 22,286,008 (GRCm39)	Y276*	probably null	Het
Vmn2r11	T	A	5: 109,207,209 (GRCm39)	D37V	probably benign	Het
Vmn2r16	T	G	5: 109,478,292 (GRCm39)	F16V	probably damaging	Het
Vmn2r65	A	T	7: 84,592,354 (GRCm39)	M538K	probably damaging	Het
Zfp143	T	A	7: 109,668,818 (GRCm39)		probably benign	Het

Other mutations in Lrrc69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01300:Lrrc69	APN	4	14,773,663 (GRCm39)	splice site	probably benign
IGL01886:Lrrc69	APN	4	14,703,984 (GRCm39)	missense	probably benign	0.01
R0588:Lrrc69	UTSW	4	14,704,001 (GRCm39)	missense	possibly damaging	0.71
R1664:Lrrc69	UTSW	4	14,775,079 (GRCm39)	missense	probably damaging	1.00
R1956:Lrrc69	UTSW	4	14,665,986 (GRCm39)	missense	possibly damaging	0.50
R1984:Lrrc69	UTSW	4	14,708,669 (GRCm39)	missense	possibly damaging	0.93
R1985:Lrrc69	UTSW	4	14,708,669 (GRCm39)	missense	possibly damaging	0.93
R1986:Lrrc69	UTSW	4	14,708,669 (GRCm39)	missense	possibly damaging	0.93
R2229:Lrrc69	UTSW	4	14,773,694 (GRCm39)	missense	probably benign	0.00
R3691:Lrrc69	UTSW	4	14,795,980 (GRCm39)	missense	possibly damaging	0.94
R5691:Lrrc69	UTSW	4	14,769,648 (GRCm39)	missense	probably damaging	1.00
R5882:Lrrc69	UTSW	4	14,708,690 (GRCm39)	missense	probably damaging	1.00
R6113:Lrrc69	UTSW	4	14,708,673 (GRCm39)	missense	probably benign	0.00
R7228:Lrrc69	UTSW	4	14,775,027 (GRCm39)	missense	probably damaging	1.00
R7880:Lrrc69	UTSW	4	14,703,946 (GRCm39)	missense	possibly damaging	0.90
R8047:Lrrc69	UTSW	4	14,773,726 (GRCm39)	missense	probably benign	0.07
R8375:Lrrc69	UTSW	4	14,795,994 (GRCm39)	missense	probably benign	0.36
R8547:Lrrc69	UTSW	4	14,704,014 (GRCm39)	missense	probably benign	0.00
R9332:Lrrc69	UTSW	4	14,774,987 (GRCm39)	missense	probably damaging	1.00
R9484:Lrrc69	UTSW	4	14,666,012 (GRCm39)	missense	probably benign	0.22

Posted On

2016-08-02