Incidental Mutation 'IGL03110:Prss37'
ID419138
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss37
Ensembl Gene ENSMUSG00000029909
Gene Nameprotease, serine 37
Synonyms1700016G05Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03110
Quality Score
Status
Chromosome6
Chromosomal Location40514824-40519508 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 40519050 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 6 (Y6C)
Ref Sequence ENSEMBL: ENSMUSP00000031967 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031967]
Predicted Effect probably benign
Transcript: ENSMUST00000031967
AA Change: Y6C

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000031967
Gene: ENSMUSG00000029909
AA Change: Y6C

DomainStartEndE-ValueType
Tryp_SPc 15 228 2.31e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148195
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201439
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona binding and migration from the uterus into the oviduct. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130204L05Rik C T 3: 91,088,319 R92H unknown Het
Acacb A G 5: 114,195,234 E473G probably damaging Het
Acp7 T C 7: 28,611,039 M458V probably benign Het
Acrbp G T 6: 125,062,473 C485F probably damaging Het
Actn2 T C 13: 12,309,607 I117V probably benign Het
Ahr T C 12: 35,504,971 E383G probably damaging Het
Cacna2d4 A T 6: 119,236,737 H39L probably benign Het
Cdh11 G T 8: 102,673,870 N155K probably damaging Het
Cldnd1 T A 16: 58,729,596 N47K possibly damaging Het
Ddb1 C T 19: 10,612,945 R279W probably damaging Het
Dido1 A T 2: 180,689,342 D104E probably damaging Het
Dnah1 A T 14: 31,266,717 S3386T probably benign Het
Galnt18 T A 7: 111,548,713 E352V probably benign Het
Gm5407 T A 16: 49,297,394 noncoding transcript Het
Gucy1b2 T C 14: 62,433,834 probably benign Het
Guf1 C A 5: 69,558,477 L87I probably damaging Het
Hikeshi A G 7: 89,935,826 S57P probably damaging Het
Igkv17-121 T A 6: 68,036,867 V17D probably damaging Het
Itgad T C 7: 128,185,985 V324A probably damaging Het
Lama1 T A 17: 67,798,986 L2072Q probably benign Het
Lrrc31 T C 3: 30,679,266 E433G probably benign Het
Mrc1 T A 2: 14,293,478 L715* probably null Het
Nbeal2 T G 9: 110,631,433 K1778Q probably damaging Het
Olfr1032 T A 2: 86,008,598 V274E probably damaging Het
Olfr1260 A T 2: 89,978,149 I124F probably damaging Het
Olfr33 C A 7: 102,713,883 G177C probably damaging Het
Ppp1r3a T A 6: 14,722,065 probably benign Het
Rapgef6 A G 11: 54,696,089 Q1602R probably damaging Het
Rbm15b T C 9: 106,885,974 T332A probably damaging Het
Snrnp70 C A 7: 45,376,859 probably benign Het
Spidr T C 16: 15,889,754 E893G probably damaging Het
Stxbp2 T C 8: 3,633,342 I74T probably damaging Het
Tgm2 G A 2: 158,131,490 Q234* probably null Het
Thbd T C 2: 148,406,796 D384G probably benign Het
Zan T C 5: 137,420,016 N2940S unknown Het
Zmat3 T A 3: 32,345,552 N100I probably damaging Het
Other mutations in Prss37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02282:Prss37 APN 6 40515383 missense possibly damaging 0.81
R0201:Prss37 UTSW 6 40516349 missense probably damaging 1.00
R0350:Prss37 UTSW 6 40514959 missense probably damaging 0.99
R2118:Prss37 UTSW 6 40515360 nonsense probably null
R2120:Prss37 UTSW 6 40515360 nonsense probably null
R2124:Prss37 UTSW 6 40515360 nonsense probably null
R2504:Prss37 UTSW 6 40517826 splice site probably null
R4711:Prss37 UTSW 6 40515447 missense probably benign 0.21
R4938:Prss37 UTSW 6 40514983 missense possibly damaging 0.81
R4983:Prss37 UTSW 6 40516136 missense probably benign 0.01
R6652:Prss37 UTSW 6 40519156 start gained probably benign
X0063:Prss37 UTSW 6 40516215 missense possibly damaging 0.65
Posted On2016-08-02