Incidental Mutation 'IGL03376:Mettl4'
| ID |
420476 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mettl4
|
| Ensembl Gene |
ENSMUSG00000055660 |
| Gene Name |
methyltransferase 4, N6-adenosine |
| Synonyms |
2410198H06Rik, A730091E08Rik, HsT661 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.298)
|
| Stock # |
IGL03376
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
95030018-95057447 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 95042799 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 346
(S346T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127142
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171284]
|
| AlphaFold |
Q3U034 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171284
AA Change: S346T
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000127142
Gene: ENSMUSG00000055660
AA Change: S346T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MT-A70
|
280 |
454 |
9.9e-43 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp6v1b2 |
T |
C |
8: 69,554,811 (GRCm39) |
|
probably benign |
Het |
| Ccdc122 |
A |
G |
14: 77,306,352 (GRCm39) |
E41G |
probably damaging |
Het |
| Cdh3 |
C |
T |
8: 107,268,036 (GRCm39) |
T357I |
probably benign |
Het |
| Cfap57 |
T |
A |
4: 118,441,917 (GRCm39) |
Q717L |
probably damaging |
Het |
| Cfap58 |
A |
T |
19: 48,023,164 (GRCm39) |
T859S |
possibly damaging |
Het |
| Cmtr1 |
C |
T |
17: 29,910,385 (GRCm39) |
R497C |
probably benign |
Het |
| Csmd2 |
T |
C |
4: 128,411,464 (GRCm39) |
I2494T |
probably benign |
Het |
| Dmkn |
C |
T |
7: 30,470,667 (GRCm39) |
T385I |
possibly damaging |
Het |
| Eml3 |
A |
G |
19: 8,911,154 (GRCm39) |
D260G |
probably damaging |
Het |
| Gbf1 |
T |
C |
19: 46,250,960 (GRCm39) |
F493L |
possibly damaging |
Het |
| Gjb5 |
C |
T |
4: 127,250,048 (GRCm39) |
R32H |
probably damaging |
Het |
| Hpx |
C |
T |
7: 105,241,458 (GRCm39) |
|
probably benign |
Het |
| Ikzf3 |
T |
A |
11: 98,379,779 (GRCm39) |
H163L |
probably damaging |
Het |
| Irak3 |
G |
A |
10: 119,982,541 (GRCm39) |
|
probably benign |
Het |
| Itih5 |
G |
A |
2: 10,211,584 (GRCm39) |
V275I |
probably benign |
Het |
| Klc1 |
G |
T |
12: 111,742,387 (GRCm39) |
E174D |
probably damaging |
Het |
| Ly6g6e |
A |
G |
17: 35,297,208 (GRCm39) |
*108W |
probably null |
Het |
| Mcph1 |
T |
C |
8: 18,646,989 (GRCm39) |
S31P |
probably damaging |
Het |
| Myo3a |
A |
T |
2: 22,490,086 (GRCm39) |
|
probably benign |
Het |
| Or2ag19 |
T |
A |
7: 106,444,677 (GRCm39) |
N286K |
probably damaging |
Het |
| Otol1 |
A |
G |
3: 69,934,845 (GRCm39) |
E279G |
probably damaging |
Het |
| Pappa |
T |
A |
4: 65,115,071 (GRCm39) |
N722K |
probably benign |
Het |
| Pramel7 |
A |
G |
2: 87,319,947 (GRCm39) |
S449P |
probably damaging |
Het |
| Rassf9 |
A |
G |
10: 102,381,059 (GRCm39) |
N145S |
probably damaging |
Het |
| Robo2 |
T |
C |
16: 73,753,380 (GRCm39) |
I158M |
probably damaging |
Het |
| Sbf1 |
A |
G |
15: 89,173,219 (GRCm39) |
|
probably benign |
Het |
| Slc30a8 |
C |
T |
15: 52,169,853 (GRCm39) |
R27* |
probably null |
Het |
| Tmco2 |
T |
A |
4: 120,966,249 (GRCm39) |
T36S |
probably benign |
Het |
| Tns4 |
T |
C |
11: 98,969,382 (GRCm39) |
S360G |
probably benign |
Het |
| Vwa8 |
A |
G |
14: 79,420,574 (GRCm39) |
|
probably null |
Het |
| Wwc1 |
C |
T |
11: 35,743,121 (GRCm39) |
R900Q |
possibly damaging |
Het |
| Zzef1 |
T |
C |
11: 72,767,377 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Mettl4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R1938:Mettl4
|
UTSW |
17 |
95,055,285 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2172:Mettl4
|
UTSW |
17 |
95,040,591 (GRCm39) |
missense |
probably benign |
|
|
R2370:Mettl4
|
UTSW |
17 |
95,040,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3621:Mettl4
|
UTSW |
17 |
95,042,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Mettl4
|
UTSW |
17 |
95,047,960 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4155:Mettl4
|
UTSW |
17 |
95,048,003 (GRCm39) |
missense |
probably benign |
|
|
R4536:Mettl4
|
UTSW |
17 |
95,042,933 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4946:Mettl4
|
UTSW |
17 |
95,047,960 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5263:Mettl4
|
UTSW |
17 |
95,047,937 (GRCm39) |
nonsense |
probably null |
|
|
R5397:Mettl4
|
UTSW |
17 |
95,034,705 (GRCm39) |
nonsense |
probably null |
|
|
R6242:Mettl4
|
UTSW |
17 |
95,042,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6508:Mettl4
|
UTSW |
17 |
95,051,373 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7069:Mettl4
|
UTSW |
17 |
95,041,061 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7941:Mettl4
|
UTSW |
17 |
95,040,622 (GRCm39) |
splice site |
probably null |
|
|
R8088:Mettl4
|
UTSW |
17 |
95,042,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8373:Mettl4
|
UTSW |
17 |
95,041,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8710:Mettl4
|
UTSW |
17 |
95,041,072 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9055:Mettl4
|
UTSW |
17 |
95,047,843 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9130:Mettl4
|
UTSW |
17 |
95,042,913 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9335:Mettl4
|
UTSW |
17 |
95,042,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9697:Mettl4
|
UTSW |
17 |
95,034,806 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Mettl4
|
UTSW |
17 |
95,040,991 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2016-08-02 |
Incidental Mutation