Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03410:Prdx3'

421776

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prdx3

Ensembl Gene

ENSMUSG00000024997

Gene Name

peroxiredoxin 3

Synonyms

SP22, D0Tohi1, Ef2l, TDXM, Mer5, Prx III, Aop1

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.400) question?

Stock #

IGL03410

Quality Score

Status

Chromosome

Chromosomal Location

60852504-60862976 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 60859848 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000025961 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025961]

AlphaFold

P20108

Predicted Effect

probably benign
Transcript: ENSMUST00000025961

SMART Domains

Protein: ENSMUSP00000025961
Gene: ENSMUSG00000024997

Domain	Start	End	E-Value	Type
low complexity region	11	27	N/A	INTRINSIC
Pfam:Redoxin	59	215	8.5e-19	PFAM
Pfam:AhpC-TSA	66	199	3.6e-39	PFAM
Pfam:1-cysPrx_C	219	254	1.2e-15	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
PHENOTYPE: Homozygotes for a null allele show increased fat mass, adipocyte hypertrophy, mitochondrial dysfunction, oxidative stress, adipokine dysregulation and altered lipid and glucose metabolism. Homozygotes for a gene-trap allele show reduced weight and high susceptibility to LPS-induced oxidative stress. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	A	17: 9,220,728 (GRCm39)	V409E	probably damaging	Het
1700086D15Rik	A	G	11: 65,043,393 (GRCm39)		probably benign	Het
Apba1	A	G	19: 23,914,945 (GRCm39)	N715S	possibly damaging	Het
Arfgef3	G	T	10: 18,476,238 (GRCm39)	A1527D	probably damaging	Het
Cmtm2a	G	T	8: 105,010,501 (GRCm39)	P133T	probably damaging	Het
Cyp2d9	T	C	15: 82,340,900 (GRCm39)	V483A	probably benign	Het
Dclre1b	T	A	3: 103,715,456 (GRCm39)	D14V	probably damaging	Het
Dock5	T	C	14: 68,083,535 (GRCm39)	I125V	probably benign	Het
Dok3	G	T	13: 55,672,044 (GRCm39)	Y211*	probably null	Het
Fat4	T	C	3: 38,945,325 (GRCm39)	V1406A	probably damaging	Het
Fbn2	A	G	18: 58,183,315 (GRCm39)	F1790S	possibly damaging	Het
Gm4787	A	T	12: 81,425,948 (GRCm39)	M70K	probably damaging	Het
Gulp1	A	T	1: 44,747,777 (GRCm39)	D10V	probably damaging	Het
Hagh	T	C	17: 25,079,916 (GRCm39)		probably benign	Het
Htt	A	G	5: 34,956,789 (GRCm39)	E206G	probably damaging	Het
Hyou1	A	G	9: 44,299,355 (GRCm39)	E682G	probably benign	Het
Ift56	T	C	6: 38,362,435 (GRCm39)	L70P	probably damaging	Het
Igkv4-59	G	T	6: 69,415,450 (GRCm39)	A35E	probably damaging	Het
Krt78	A	G	15: 101,862,421 (GRCm39)	V80A	probably damaging	Het
Lars2	G	A	9: 123,247,841 (GRCm39)	A333T	possibly damaging	Het
Lrrc4	G	A	6: 28,830,515 (GRCm39)	R367W	probably damaging	Het
Med1	A	T	11: 98,080,009 (GRCm39)	M44K	possibly damaging	Het
Mep1a	T	A	17: 43,788,986 (GRCm39)		probably null	Het
Mmrn1	A	G	6: 60,952,819 (GRCm39)	I367V	probably benign	Het
Myo18a	T	C	11: 77,738,830 (GRCm39)	L1677P	probably damaging	Het
Neb	T	C	2: 52,209,717 (GRCm39)	T246A	probably benign	Het
Nkiras1	A	G	14: 18,280,073 (GRCm38)	R155G	probably benign	Het
Nrip1	T	C	16: 76,089,379 (GRCm39)	N726S	probably benign	Het
Nyap2	A	G	1: 81,219,156 (GRCm39)	T393A	possibly damaging	Het
Oprm1	A	T	10: 6,780,051 (GRCm39)	I238F	probably damaging	Het
Or4b1b	A	G	2: 90,112,557 (GRCm39)	Y121H	probably damaging	Het
Or4b1d	G	A	2: 89,969,489 (GRCm39)		probably benign	Het
Or5m11b	T	A	2: 85,805,764 (GRCm39)	M59K	probably damaging	Het
Pcnx2	T	A	8: 126,613,779 (GRCm39)	E557D	probably damaging	Het
Pole	A	G	5: 110,472,425 (GRCm39)	I1563V	probably benign	Het
Pramel21	C	A	4: 143,341,851 (GRCm39)	H93Q	probably benign	Het
Rgsl1	C	T	1: 153,669,501 (GRCm39)	R295K	probably null	Het
Rhbdl2	T	A	4: 123,723,463 (GRCm39)	L289*	probably null	Het
Rnps1	A	G	17: 24,640,835 (GRCm39)		probably benign	Het
Rpgrip1	A	G	14: 52,395,823 (GRCm39)		probably benign	Het
Ryr2	A	T	13: 11,603,033 (GRCm39)	Y4518N	probably damaging	Het
Scyl3	A	G	1: 163,772,436 (GRCm39)	N296S	probably damaging	Het
Sipa1l3	G	A	7: 29,047,964 (GRCm39)	T1308M	probably damaging	Het
Slc39a9	A	G	12: 80,691,662 (GRCm39)	D3G	probably damaging	Het
Slc4a9	A	G	18: 36,662,740 (GRCm39)	E165G	probably benign	Het
Slc6a3	A	T	13: 73,686,776 (GRCm39)	I48F	probably benign	Het
Stxbp3	C	T	3: 108,709,476 (GRCm39)	C354Y	probably damaging	Het
Terb1	C	A	8: 105,199,674 (GRCm39)		probably benign	Het
Tfrc	G	A	16: 32,443,649 (GRCm39)		probably null	Het
Toporsl	A	C	4: 52,611,134 (GRCm39)	R342S	probably benign	Het
Ube2d3	T	A	3: 135,170,978 (GRCm39)	W141R	probably damaging	Het
Vps13b	G	T	15: 35,910,486 (GRCm39)	V3417L	probably benign	Het

Other mutations in Prdx3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02444:Prdx3	APN	19	60,859,899 (GRCm39)	missense	possibly damaging	0.76
IGL03114:Prdx3	APN	19	60,861,556 (GRCm39)	splice site	probably benign
R0058:Prdx3	UTSW	19	60,862,950 (GRCm39)	start gained	probably benign
R1612:Prdx3	UTSW	19	60,862,872 (GRCm39)	missense	possibly damaging	0.94
R3899:Prdx3	UTSW	19	60,853,621 (GRCm39)	missense	probably benign	0.44
R4654:Prdx3	UTSW	19	60,853,674 (GRCm39)	missense	possibly damaging	0.92
R4720:Prdx3	UTSW	19	60,858,551 (GRCm39)	missense	possibly damaging	0.90
R4760:Prdx3	UTSW	19	60,861,621 (GRCm39)	missense	possibly damaging	0.63
R5643:Prdx3	UTSW	19	60,859,963 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02