Incidental Mutation 'IGL01092:Ppp1r26'
| ID |
50478 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ppp1r26
|
| Ensembl Gene |
ENSMUSG00000035829 |
| Gene Name |
protein phosphatase 1, regulatory subunit 26 |
| Synonyms |
LOC241289 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01092
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
28336812-28345520 bp(+) (GRCm39) |
| Type of Mutation |
utr 3 prime |
| DNA Base Change (assembly) |
C to T
at 28343872 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139546
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040324]
[ENSMUST00000189694]
|
| AlphaFold |
Q6A025 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040324
|
| SMART Domains |
Protein: ENSMUSP00000042173
Gene: ENSMUSG00000035829
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PPP1R26_N
|
1 |
812 |
N/A |
PFAM |
|
low complexity region
|
901 |
913 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128199
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150362
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154081
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189694
|
| SMART Domains |
Protein: ENSMUSP00000139546
Gene: ENSMUSG00000035829
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
122 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
487 |
504 |
N/A |
INTRINSIC |
|
low complexity region
|
515 |
536 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
559 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
766 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
901 |
913 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgap33 |
T |
C |
7: 30,229,371 (GRCm39) |
R335G |
probably damaging |
Het |
| Atad2b |
C |
T |
12: 5,067,987 (GRCm39) |
S995L |
probably damaging |
Het |
| Atrn |
A |
T |
2: 130,789,556 (GRCm39) |
R340* |
probably null |
Het |
| Ccdc83 |
A |
T |
7: 89,896,313 (GRCm39) |
D85E |
probably benign |
Het |
| Chd2 |
A |
T |
7: 73,091,434 (GRCm39) |
H1602Q |
possibly damaging |
Het |
| Cog2 |
A |
G |
8: 125,272,019 (GRCm39) |
D511G |
probably damaging |
Het |
| Col4a4 |
G |
T |
1: 82,444,266 (GRCm39) |
P1334T |
unknown |
Het |
| Creb3l4 |
T |
C |
3: 90,145,045 (GRCm39) |
E369G |
probably damaging |
Het |
| Crnkl1 |
T |
C |
2: 145,761,868 (GRCm39) |
K563R |
probably benign |
Het |
| Dbi |
T |
C |
1: 120,041,207 (GRCm39) |
K131E |
probably benign |
Het |
| Edn1 |
A |
G |
13: 42,457,147 (GRCm39) |
D60G |
probably damaging |
Het |
| Erbin |
T |
C |
13: 103,970,520 (GRCm39) |
N1032S |
probably damaging |
Het |
| Ero1a |
T |
C |
14: 45,541,043 (GRCm39) |
D107G |
probably benign |
Het |
| Glmn |
A |
T |
5: 107,726,378 (GRCm39) |
|
probably null |
Het |
| Grxcr1 |
T |
C |
5: 68,267,905 (GRCm39) |
|
probably benign |
Het |
| Itih3 |
T |
A |
14: 30,631,738 (GRCm39) |
K593I |
probably damaging |
Het |
| Kmt2b |
T |
C |
7: 30,279,932 (GRCm39) |
Y1356C |
probably damaging |
Het |
| Lrp1b |
C |
T |
2: 40,640,959 (GRCm39) |
C3495Y |
probably damaging |
Het |
| Map3k13 |
A |
T |
16: 21,746,766 (GRCm39) |
T950S |
probably damaging |
Het |
| Me1 |
A |
T |
9: 86,480,801 (GRCm39) |
V348D |
probably damaging |
Het |
| Morc2a |
T |
C |
11: 3,634,042 (GRCm39) |
V718A |
probably benign |
Het |
| Myh7 |
T |
C |
14: 55,209,089 (GRCm39) |
E1883G |
possibly damaging |
Het |
| Or10ak14 |
T |
A |
4: 118,610,959 (GRCm39) |
I259F |
possibly damaging |
Het |
| Or8b49 |
T |
G |
9: 38,506,201 (GRCm39) |
I228R |
probably damaging |
Het |
| Pdcd6ip |
A |
G |
9: 113,509,249 (GRCm39) |
|
probably benign |
Het |
| Plcb3 |
T |
A |
19: 6,932,690 (GRCm39) |
E1025V |
probably benign |
Het |
| Prkd1 |
T |
C |
12: 50,430,298 (GRCm39) |
|
probably benign |
Het |
| Rwdd4a |
C |
T |
8: 47,997,147 (GRCm39) |
T122M |
possibly damaging |
Het |
| Sdhb |
T |
G |
4: 140,704,791 (GRCm39) |
C251G |
probably damaging |
Het |
| Siglec1 |
A |
T |
2: 130,921,137 (GRCm39) |
I678N |
probably damaging |
Het |
| Snrnp70 |
T |
C |
7: 45,026,801 (GRCm39) |
D215G |
probably damaging |
Het |
| Ston1 |
A |
G |
17: 88,951,871 (GRCm39) |
E674G |
probably benign |
Het |
| Tbl3 |
T |
C |
17: 24,920,879 (GRCm39) |
|
probably benign |
Het |
| Tbl3 |
A |
T |
17: 24,924,226 (GRCm39) |
I177N |
probably damaging |
Het |
| Tnrc6c |
T |
C |
11: 117,612,811 (GRCm39) |
V483A |
probably damaging |
Het |
|
| Other mutations in Ppp1r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00975:Ppp1r26
|
APN |
2 |
28,343,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02061:Ppp1r26
|
APN |
2 |
28,340,639 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02399:Ppp1r26
|
APN |
2 |
28,343,292 (GRCm39) |
missense |
probably benign |
|
|
R0518:Ppp1r26
|
UTSW |
2 |
28,342,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0763:Ppp1r26
|
UTSW |
2 |
28,340,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1082:Ppp1r26
|
UTSW |
2 |
28,342,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1477:Ppp1r26
|
UTSW |
2 |
28,342,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1512:Ppp1r26
|
UTSW |
2 |
28,341,528 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2157:Ppp1r26
|
UTSW |
2 |
28,342,370 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2228:Ppp1r26
|
UTSW |
2 |
28,343,798 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2275:Ppp1r26
|
UTSW |
2 |
28,342,713 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3015:Ppp1r26
|
UTSW |
2 |
28,342,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4402:Ppp1r26
|
UTSW |
2 |
28,341,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4614:Ppp1r26
|
UTSW |
2 |
28,340,860 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5521:Ppp1r26
|
UTSW |
2 |
28,341,438 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5873:Ppp1r26
|
UTSW |
2 |
28,341,617 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5988:Ppp1r26
|
UTSW |
2 |
28,342,566 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6060:Ppp1r26
|
UTSW |
2 |
28,341,042 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7007:Ppp1r26
|
UTSW |
2 |
28,341,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7501:Ppp1r26
|
UTSW |
2 |
28,340,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8812:Ppp1r26
|
UTSW |
2 |
28,341,192 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8986:Ppp1r26
|
UTSW |
2 |
28,342,802 (GRCm39) |
nonsense |
probably null |
|
|
R9213:Ppp1r26
|
UTSW |
2 |
28,343,649 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1176:Ppp1r26
|
UTSW |
2 |
28,342,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ppp1r26
|
UTSW |
2 |
28,343,492 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Ppp1r26
|
UTSW |
2 |
28,342,880 (GRCm39) |
missense |
probably benign |
0.45 |
|
Z1177:Ppp1r26
|
UTSW |
2 |
28,340,904 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Posted On |
2013-06-21 |
Incidental Mutation