Incidental Mutation 'R6634:Gstp1'
ID 525420
Institutional Source Beutler Lab
Gene Symbol Gstp1
Ensembl Gene ENSMUSG00000060803
Gene Name glutathione S-transferase, pi 1
Synonyms Gst p-1, GstpiB
MMRRC Submission 044756-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.331) question?
Stock # R6634 (G1)
Quality Score 198.009
Status Validated
Chromosome 19
Chromosomal Location 4085411-4087912 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 4085510 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 199 (H199L)
Ref Sequence ENSEMBL: ENSMUSP00000129565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042700] [ENSMUST00000169613]
AlphaFold P19157
PDB Structure GLUTATHIONE S-TRANSFERASE YFYF CYS 47-CARBOXYMETHYLATED CLASS PI, FREE ENZYME [X-RAY DIFFRACTION]
1.8 ANGSTROMS MOLECULAR STRUCTURE OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS [X-RAY DIFFRACTION]
1.8 ANGSTROMS MOLECULAR STRUCTURE OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS [X-RAY DIFFRACTION]
GLUTATHIONE S-TRANSFERASE YFYF, CLASS PI, COMPLEXED WITH GLUTATHIONE [X-RAY DIFFRACTION]
MODIFIED GLUTATHIONE S-TRANSFERASE (PI) COMPLEXED WITH S (P-NITROBENZYL)GLUTATHIONE [X-RAY DIFFRACTION]
MOLECULAR STRUCTURE AT 1.8 ANGSTROMS OF MOUSE LIVER CLASS PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS [X-RAY DIFFRACTION]
Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-hexyl glutathione [X-RAY DIFFRACTION]
Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-(p-nitrobenzyl) Glutathione [X-RAY DIFFRACTION]
Structure of Glutathione-S-Transferase C169A Mutant [X-RAY DIFFRACTION]
1.8 Angstroms molecular structure of mouse liver glutathione S-transferase mutant C47A complexed with S-(P-nitrobenzyl)glutathione [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000042700
SMART Domains Protein: ENSMUSP00000038931
Gene: ENSMUSG00000038155

DomainStartEndE-ValueType
Pfam:GST_N 2 75 4.2e-8 PFAM
Pfam:GST_C 97 188 1.4e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169613
AA Change: H199L

PolyPhen 2 Score 0.208 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000129565
Gene: ENSMUSG00000060803
AA Change: H199L

DomainStartEndE-ValueType
Pfam:GST_N 4 75 2.3e-8 PFAM
Pfam:GST_C 97 188 1.5e-15 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.8%
Validation Efficiency 97% (31/32)
MGI Phenotype PHENOTYPE: Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik C T 4: 103,094,127 (GRCm39) probably null Het
Alox12b C A 11: 69,059,647 (GRCm39) Y566* probably null Het
Chl1 T A 6: 103,667,220 (GRCm39) S403R probably damaging Het
Cpa5 T A 6: 30,626,363 (GRCm39) D241E probably damaging Het
Crebbp C T 16: 3,937,670 (GRCm39) A698T possibly damaging Het
Cyp2t4 C A 7: 26,855,213 (GRCm39) C121* probably null Het
Dkkl1 C A 7: 44,859,882 (GRCm39) R56L possibly damaging Het
Ebf3 A G 7: 136,802,889 (GRCm39) V387A probably damaging Het
Efcab3 T C 11: 104,784,609 (GRCm39) M2797T probably benign Het
Fer1l5 A G 1: 36,450,466 (GRCm39) T1212A probably damaging Het
Galnt16 T A 12: 80,565,944 (GRCm39) M1K probably null Het
Gm5800 A G 14: 51,953,595 (GRCm39) S7P possibly damaging Het
Herc1 T C 9: 66,345,026 (GRCm39) S1940P probably benign Het
Igkv8-24 C T 6: 70,194,365 (GRCm39) W14* probably null Het
Iqcd C A 5: 120,738,556 (GRCm39) Q125K probably benign Het
Lpin2 T A 17: 71,553,413 (GRCm39) D812E probably damaging Het
Ltb4r2 T A 14: 55,999,962 (GRCm39) probably null Het
Morc2a T C 11: 3,622,376 (GRCm39) probably null Het
Myh1 A T 11: 67,099,890 (GRCm39) N600I possibly damaging Het
Nedd9 T A 13: 41,465,584 (GRCm39) K685N probably damaging Het
Or10aa3 A G 1: 173,878,535 (GRCm39) I199V probably benign Het
Otogl A C 10: 107,698,165 (GRCm39) V735G probably damaging Het
Pcnx1 T A 12: 81,964,656 (GRCm39) Y274* probably null Het
Pias1 A T 9: 62,826,706 (GRCm39) I252N probably damaging Het
Pitpnm3 T C 11: 71,942,755 (GRCm39) D844G probably null Het
Satb2 G T 1: 56,884,880 (GRCm39) S348* probably null Het
Sfxn1 T A 13: 54,247,048 (GRCm39) V180D probably damaging Het
Slc35g3 A T 11: 69,651,109 (GRCm39) V314D probably damaging Het
Tmem200c C A 17: 69,149,101 (GRCm39) D561E probably benign Het
Usp53 T A 3: 122,757,935 (GRCm39) Q69L probably benign Het
Other mutations in Gstp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1658:Gstp1 UTSW 19 4,087,375 (GRCm39) missense probably damaging 0.99
R1848:Gstp1 UTSW 19 4,086,795 (GRCm39) splice site probably benign
R3432:Gstp1 UTSW 19 4,086,695 (GRCm39) missense possibly damaging 0.50
R8755:Gstp1 UTSW 19 4,086,698 (GRCm39) missense probably damaging 1.00
RF021:Gstp1 UTSW 19 4,085,507 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GTCCCACCCTTATGTGCAAG -3'
(R):5'- TGACCAGGTGAGCATCTCTTG -3'

Sequencing Primer
(F):5'- ACCCTTATGTGCAAGTTTCCTG -3'
(R):5'- CATTGCCTTTGCCTTGTGGATAAG -3'
Posted On 2018-06-22