Mutagenetix > Incidental Mutation

Incidental Mutation 'R6589:Cramp1'

526388

Institutional Source

Beutler Lab

Gene Symbol

Cramp1

Ensembl Gene

ENSMUSG00000038002

Gene Name

cramped chromatin regulator 1

Synonyms

5830477H08Rik, Tce4, Cramp1l

MMRRC Submission

044713-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6589 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

25180200-25234762 bp(-) (GRCm39)

Type of Mutation

splice site (4 bp from exon)

DNA Base Change (assembly)

T to C at 25196466 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000073060 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073337]

AlphaFold

Q6PG95

Predicted Effect

probably null
Transcript: ENSMUST00000073337

SMART Domains

Protein: ENSMUSP00000073060
Gene: ENSMUSG00000038002

Domain	Start	End	E-Value	Type
low complexity region	11	20	N/A	INTRINSIC
low complexity region	29	43	N/A	INTRINSIC
low complexity region	51	64	N/A	INTRINSIC
low complexity region	100	126	N/A	INTRINSIC
low complexity region	134	147	N/A	INTRINSIC
SANT	159	219	3.68e-3	SMART
low complexity region	479	503	N/A	INTRINSIC
low complexity region	548	562	N/A	INTRINSIC
low complexity region	792	803	N/A	INTRINSIC
low complexity region	833	845	N/A	INTRINSIC
low complexity region	889	903	N/A	INTRINSIC
low complexity region	1069	1086	N/A	INTRINSIC
low complexity region	1113	1124	N/A	INTRINSIC
low complexity region	1141	1156	N/A	INTRINSIC
low complexity region	1171	1185	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.0%

Validation Efficiency

100% (26/26)

MGI Phenotype

PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit cleft palate. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd55	G	A	13: 112,485,397 (GRCm39)		probably null	Het
Asic2	G	T	11: 80,777,430 (GRCm39)	A427D	possibly damaging	Het
B3gnt2	T	A	11: 22,787,117 (GRCm39)	I24F	probably damaging	Het
BC030500	T	C	8: 59,365,956 (GRCm39)		probably benign	Het
Cdh4	G	A	2: 179,523,789 (GRCm39)		probably null	Het
Fam72a	A	T	1: 131,461,554 (GRCm39)	I80F	probably damaging	Het
Fbxo43	T	C	15: 36,162,686 (GRCm39)	T174A	probably damaging	Het
Fgf11	C	A	11: 69,690,261 (GRCm39)	V109L	probably damaging	Het
Fggy	A	G	4: 95,485,875 (GRCm39)	I74V	probably benign	Het
Fshr	T	C	17: 89,296,035 (GRCm39)	D224G	probably damaging	Het
Gm6465	A	G	5: 11,898,128 (GRCm39)	T81A	possibly damaging	Het
Hdac9	T	C	12: 34,265,028 (GRCm39)	E908G	probably damaging	Het
Hspa4l	T	G	3: 40,711,487 (GRCm39)	L121V	probably damaging	Het
Klk1b16	A	G	7: 43,790,894 (GRCm39)	D232G	probably benign	Het
Lpl	G	T	8: 69,349,459 (GRCm39)	M328I	probably benign	Het
Mgat4a	T	C	1: 37,483,976 (GRCm39)	E498G	probably damaging	Het
Mup11	T	A	4: 60,615,540 (GRCm39)	Q91L	possibly damaging	Het
Myoc	T	A	1: 162,476,188 (GRCm39)	Y297*	probably null	Het
Or14j5	T	A	17: 38,161,727 (GRCm39)	Y81*	probably null	Het
Semp2l1	A	T	1: 32,585,792 (GRCm39)	D39E	probably benign	Het
Siva1	A	G	12: 112,613,272 (GRCm39)	E40G	probably damaging	Het
Smarca2	T	A	19: 26,597,284 (GRCm39)	H55Q	possibly damaging	Het
Taf1b	A	G	12: 24,606,527 (GRCm39)	E449G	possibly damaging	Het
Tafa2	T	A	10: 123,540,297 (GRCm39)	V51E	probably damaging	Het
Tcaf3	A	T	6: 42,570,995 (GRCm39)	N252K	possibly damaging	Het
Trim3	A	G	7: 105,267,167 (GRCm39)	L404P	probably damaging	Het
Vmn2r114	T	C	17: 23,510,642 (GRCm39)	T613A	probably damaging	Het
Vmn2r-ps158	T	A	7: 42,673,022 (GRCm39)	S142T	possibly damaging	Het
Zfp358	T	A	8: 3,545,907 (GRCm39)	F163Y	probably damaging	Het

Other mutations in Cramp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00566:Cramp1	APN	17	25,202,925 (GRCm39)	missense	probably benign	0.11
IGL01360:Cramp1	APN	17	25,216,547 (GRCm39)	missense	probably damaging	1.00
IGL01966:Cramp1	APN	17	25,201,917 (GRCm39)	missense	probably benign	0.01
IGL02211:Cramp1	APN	17	25,196,610 (GRCm39)	missense	possibly damaging	0.94
IGL02474:Cramp1	APN	17	25,204,024 (GRCm39)	missense	probably damaging	0.98
IGL02798:Cramp1	APN	17	25,187,894 (GRCm39)	splice site	probably benign
IGL03340:Cramp1	APN	17	25,192,516 (GRCm39)	missense	probably damaging	1.00
Interred	UTSW	17	25,202,956 (GRCm39)	missense	probably damaging	0.99
R0106:Cramp1	UTSW	17	25,191,350 (GRCm39)	missense	probably benign	0.30
R1054:Cramp1	UTSW	17	25,202,151 (GRCm39)	missense	probably damaging	1.00
R1220:Cramp1	UTSW	17	25,201,211 (GRCm39)	missense	probably damaging	1.00
R1341:Cramp1	UTSW	17	25,196,514 (GRCm39)	missense	probably damaging	1.00
R1491:Cramp1	UTSW	17	25,191,323 (GRCm39)	missense	probably benign	0.17
R1610:Cramp1	UTSW	17	25,202,925 (GRCm39)	missense	probably benign	0.11
R1649:Cramp1	UTSW	17	25,202,217 (GRCm39)	missense	probably damaging	1.00
R1795:Cramp1	UTSW	17	25,183,884 (GRCm39)	missense	probably damaging	1.00
R1856:Cramp1	UTSW	17	25,187,952 (GRCm39)	missense	probably damaging	1.00
R1881:Cramp1	UTSW	17	25,196,656 (GRCm39)	splice site	probably benign
R1968:Cramp1	UTSW	17	25,183,913 (GRCm39)	missense	probably damaging	1.00
R2047:Cramp1	UTSW	17	25,222,189 (GRCm39)	nonsense	probably null
R2099:Cramp1	UTSW	17	25,192,059 (GRCm39)	missense	probably benign	0.01
R2298:Cramp1	UTSW	17	25,216,454 (GRCm39)	missense	probably damaging	0.96
R3752:Cramp1	UTSW	17	25,190,532 (GRCm39)	missense	probably damaging	1.00
R3821:Cramp1	UTSW	17	25,193,756 (GRCm39)	missense	probably damaging	1.00
R3861:Cramp1	UTSW	17	25,216,588 (GRCm39)	splice site	probably benign
R4399:Cramp1	UTSW	17	25,198,559 (GRCm39)	missense	probably damaging	1.00
R4847:Cramp1	UTSW	17	25,204,063 (GRCm39)	missense	probably damaging	1.00
R4883:Cramp1	UTSW	17	25,201,293 (GRCm39)	missense	probably benign
R5579:Cramp1	UTSW	17	25,192,087 (GRCm39)	missense	possibly damaging	0.89
R5631:Cramp1	UTSW	17	25,204,577 (GRCm39)	missense	possibly damaging	0.93
R5716:Cramp1	UTSW	17	25,193,709 (GRCm39)	missense	probably damaging	0.99
R6631:Cramp1	UTSW	17	25,202,931 (GRCm39)	missense	probably benign	0.40
R7307:Cramp1	UTSW	17	25,193,719 (GRCm39)	missense	possibly damaging	0.94
R7323:Cramp1	UTSW	17	25,201,379 (GRCm39)	missense	possibly damaging	0.90
R7672:Cramp1	UTSW	17	25,201,440 (GRCm39)	missense	probably damaging	0.96
R7832:Cramp1	UTSW	17	25,202,196 (GRCm39)	missense	probably damaging	0.96
R8071:Cramp1	UTSW	17	25,201,674 (GRCm39)	missense	probably damaging	0.99
R8244:Cramp1	UTSW	17	25,190,384 (GRCm39)	missense	probably damaging	1.00
R8430:Cramp1	UTSW	17	25,196,536 (GRCm39)	missense	probably damaging	1.00
R8783:Cramp1	UTSW	17	25,193,732 (GRCm39)	missense	probably damaging	0.99
R8890:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R8892:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R8894:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R8937:Cramp1	UTSW	17	25,202,956 (GRCm39)	missense	probably damaging	0.99
R8941:Cramp1	UTSW	17	25,202,114 (GRCm39)	missense	probably damaging	1.00
R9029:Cramp1	UTSW	17	25,232,884 (GRCm39)	missense	probably damaging	1.00
R9047:Cramp1	UTSW	17	25,198,603 (GRCm39)	missense	possibly damaging	0.90
R9149:Cramp1	UTSW	17	25,187,920 (GRCm39)	missense	probably damaging	0.99
R9262:Cramp1	UTSW	17	25,232,920 (GRCm39)	missense	probably damaging	0.99
R9460:Cramp1	UTSW	17	25,222,281 (GRCm39)	missense	probably damaging	1.00
R9614:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9615:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9651:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9652:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9653:Cramp1	UTSW	17	25,201,783 (GRCm39)	missense	probably damaging	1.00
R9665:Cramp1	UTSW	17	25,196,545 (GRCm39)	missense	probably damaging	1.00
R9753:Cramp1	UTSW	17	25,191,320 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

Posted On

2018-06-25