Incidental Mutation 'IGL01152:Pim2'
ID53371
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pim2
Ensembl Gene ENSMUSG00000031155
Gene Nameproviral integration site 2
SynonymsDXCch3, Pim-2
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01152
Quality Score
Status
ChromosomeX
Chromosomal Location7878262-7883432 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) C to A at 7878422 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033494] [ENSMUST00000115665] [ENSMUST00000115666] [ENSMUST00000115667] [ENSMUST00000115668] [ENSMUST00000223553]
Predicted Effect probably benign
Transcript: ENSMUST00000033494
SMART Domains Protein: ENSMUSP00000033494
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
low complexity region 118 141 N/A INTRINSIC
low complexity region 157 164 N/A INTRINSIC
Pfam:OTU 219 331 1.4e-22 PFAM
low complexity region 425 438 N/A INTRINSIC
low complexity region 445 457 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000033495
AA Change: A40D
SMART Domains Protein: ENSMUSP00000033495
Gene: ENSMUSG00000031155
AA Change: A40D

DomainStartEndE-ValueType
low complexity region 6 41 N/A INTRINSIC
low complexity region 69 79 N/A INTRINSIC
S_TKc 91 345 1.19e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115665
SMART Domains Protein: ENSMUSP00000111329
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
Pfam:OTU 176 288 2.8e-23 PFAM
low complexity region 376 389 N/A INTRINSIC
low complexity region 396 408 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115666
SMART Domains Protein: ENSMUSP00000111330
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
low complexity region 118 141 N/A INTRINSIC
low complexity region 157 164 N/A INTRINSIC
Pfam:OTU 219 331 3.2e-23 PFAM
low complexity region 425 438 N/A INTRINSIC
low complexity region 445 457 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115667
SMART Domains Protein: ENSMUSP00000111331
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
low complexity region 118 141 N/A INTRINSIC
low complexity region 157 164 N/A INTRINSIC
Pfam:OTU 219 338 3.4e-20 PFAM
low complexity region 430 443 N/A INTRINSIC
low complexity region 450 462 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115668
SMART Domains Protein: ENSMUSP00000111332
Gene: ENSMUSG00000031154

DomainStartEndE-ValueType
low complexity region 9 53 N/A INTRINSIC
low complexity region 58 78 N/A INTRINSIC
low complexity region 84 98 N/A INTRINSIC
low complexity region 100 114 N/A INTRINSIC
Pfam:OTU 176 288 1.2e-22 PFAM
low complexity region 382 395 N/A INTRINSIC
low complexity region 402 414 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126715
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145177
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150644
Predicted Effect unknown
Transcript: ENSMUST00000190448
AA Change: A35D
SMART Domains Protein: ENSMUSP00000140602
Gene: ENSMUSG00000031155
AA Change: A35D

DomainStartEndE-ValueType
low complexity region 6 41 N/A INTRINSIC
low complexity region 69 79 N/A INTRINSIC
S_TKc 91 345 1.19e-71 SMART
Predicted Effect unknown
Transcript: ENSMUST00000223553
AA Change: A35D
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
PHENOTYPE: Homozygous null mice display reduced T cell proliferation in response to suboptimal alphaCD3 activation. Mice homozygous for a null allele exhibit reduced LPS-stimulated IL6 production from splenotcytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530077C05Rik A T 9: 22,435,164 H356L probably benign Het
A730013G03Rik T G 1: 192,833,639 noncoding transcript Het
Abcb4 G A 5: 8,950,678 V1031M probably benign Het
Abcc4 A G 14: 118,599,385 S655P probably damaging Het
Actn1 T C 12: 80,199,046 K121R probably damaging Het
Aldh1l2 T A 10: 83,522,886 R82* probably null Het
Arhgap31 T A 16: 38,602,239 H1155L possibly damaging Het
Atp8a1 G T 5: 67,847,206 P2Q probably damaging Het
Bcs1l A G 1: 74,592,015 M401V possibly damaging Het
Brca2 A T 5: 150,542,390 N1873I probably damaging Het
Cenpj T C 14: 56,552,300 N764S probably benign Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Clk1 A T 1: 58,413,452 C359S possibly damaging Het
Clk2 T A 3: 89,176,511 F479I probably damaging Het
Cul4b T C X: 38,543,370 M709V probably damaging Het
D130052B06Rik G T 11: 33,623,620 probably null Het
Dgkb T A 12: 38,084,234 N46K probably damaging Het
Dnah9 C T 11: 66,072,056 R1811H probably damaging Het
Dnajc18 T C 18: 35,680,873 N281S probably benign Het
Galnt5 A T 2: 58,025,393 I654L probably benign Het
Gm9989 T G 3: 81,922,211 noncoding transcript Het
Gpr179 T C 11: 97,337,411 E1306G probably benign Het
Gsc C A 12: 104,471,605 K219N probably damaging Het
Gsx2 A T 5: 75,075,791 I11F probably damaging Het
Igdcc4 A C 9: 65,135,164 E121A probably damaging Het
Lama2 C T 10: 27,208,429 R915H probably benign Het
Large2 A G 2: 92,370,639 L64P probably damaging Het
Lztr1 C A 16: 17,522,453 Q136K probably damaging Het
Mageb18 A G X: 92,119,824 W271R possibly damaging Het
Magoh A C 4: 107,885,006 probably benign Het
Mrgprx1 T C 7: 48,021,486 H171R probably benign Het
Muc1 C A 3: 89,230,754 T301K probably benign Het
Nbas C T 12: 13,360,958 L868F probably damaging Het
Nwd2 A G 5: 63,806,529 D1152G possibly damaging Het
Olfr493 C T 7: 108,346,949 A11T probably benign Het
Olfr77 G A 9: 19,920,949 V247M possibly damaging Het
Ovgp1 T A 3: 105,986,172 D420E possibly damaging Het
Pacsin3 A G 2: 91,263,776 D350G probably benign Het
Pcolce2 A T 9: 95,692,923 N309Y probably damaging Het
Plcb1 A G 2: 134,813,659 Y53C probably damaging Het
Pogk T C 1: 166,408,478 E18G probably damaging Het
Pxdn T A 12: 30,001,937 D704E probably damaging Het
Rb1 C A 14: 73,205,870 S781I probably damaging Het
Rnpepl1 A G 1: 92,915,899 H247R possibly damaging Het
Scube1 A T 15: 83,613,570 F697I probably damaging Het
Sel1l3 G T 5: 53,116,333 H1064N probably damaging Het
Serinc3 A G 2: 163,636,911 Y99H probably damaging Het
Slc36a2 T A 11: 55,169,847 probably benign Het
Smarcc1 A C 9: 110,139,625 E130A possibly damaging Het
Strc A G 2: 121,370,795 M1273T probably benign Het
Tmem116 A G 5: 121,463,799 I21V probably benign Het
Tmem190 T C 7: 4,784,026 probably benign Het
Trim63 C T 4: 134,325,676 A316V probably benign Het
Ugt2b34 T C 5: 86,901,203 E321G probably damaging Het
Zfat T A 15: 68,110,504 R1053S probably damaging Het
Posted On2013-06-21