Incidental Mutation 'R6692:Stk19'
ID 543505
Institutional Source Beutler Lab
Gene Symbol Stk19
Ensembl Gene ENSMUSG00000061207
Gene Name serine/threonine kinase 19
Synonyms RP1, G11
MMRRC Submission 044810-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.398) question?
Stock # R6692 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 35042969-35055879 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 35043770 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Serine at position 95 (G95S)
Ref Sequence ENSEMBL: ENSMUSP00000124667 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077477] [ENSMUST00000159333] [ENSMUST00000161885]
AlphaFold Q9JHN8
Predicted Effect silent
Transcript: ENSMUST00000077477
SMART Domains Protein: ENSMUSP00000076686
Gene: ENSMUSG00000061207

DomainStartEndE-ValueType
Pfam:Stk19 37 251 1e-37 PFAM
Predicted Effect silent
Transcript: ENSMUST00000159333
SMART Domains Protein: ENSMUSP00000125311
Gene: ENSMUSG00000061207

DomainStartEndE-ValueType
Pfam:Stk19 1 129 3.2e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161885
AA Change: G95S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000162055
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahcyl1 C T 3: 107,582,401 (GRCm39) G54D probably damaging Het
Aldh1b1 T C 4: 45,803,427 (GRCm39) C322R probably damaging Het
Cdc14b T C 13: 64,363,377 (GRCm39) I258V probably damaging Het
Cenph T C 13: 100,909,243 (GRCm39) I55V probably benign Het
Cep290 T A 10: 100,405,006 (GRCm39) probably null Het
Ces2b A G 8: 105,563,919 (GRCm39) Y431C probably damaging Het
Cyp4f17 T C 17: 32,725,950 (GRCm39) S28P possibly damaging Het
Cyp4f40 C G 17: 32,894,716 (GRCm39) T427S possibly damaging Het
Exoc2 A G 13: 31,119,490 (GRCm39) I137T probably benign Het
Fam168b C A 1: 34,875,822 (GRCm39) G21V probably damaging Het
G3bp1 T A 11: 55,384,335 (GRCm39) D168E probably benign Het
Impg2 T A 16: 56,072,696 (GRCm39) L376H probably damaging Het
Kdm4d A T 9: 14,374,361 (GRCm39) M499K probably benign Het
Lonp1 C T 17: 56,926,230 (GRCm39) V426M probably damaging Het
Lypla2 C A 4: 135,698,173 (GRCm39) A26S probably benign Het
Map3k13 T C 16: 21,723,987 (GRCm39) V323A possibly damaging Het
Mdfic2 T G 6: 98,225,169 (GRCm39) H38P possibly damaging Het
Mov10 A G 3: 104,725,360 (GRCm39) L83P probably damaging Het
Mphosph9 G T 5: 124,398,179 (GRCm39) A1039D probably damaging Het
Nedd1 T C 10: 92,534,199 (GRCm39) K317R possibly damaging Het
Or10ag55-ps1 A G 2: 87,139,336 (GRCm39) T68A possibly damaging Het
Pde3a T A 6: 141,425,072 (GRCm39) S623T probably damaging Het
Pld1 T A 3: 28,095,348 (GRCm39) M227K probably benign Het
Rell1 T G 5: 64,095,210 (GRCm39) K85N probably damaging Het
Rhbdf1 T C 11: 32,165,652 (GRCm39) T93A probably damaging Het
Sccpdh T A 1: 179,511,792 (GRCm39) M88K possibly damaging Het
Siae T G 9: 37,554,095 (GRCm39) probably null Het
Slc22a16 G A 10: 40,479,901 (GRCm39) E637K unknown Het
Stpg2 G A 3: 139,228,738 (GRCm39) probably null Het
Sult2a5 T A 7: 13,358,057 (GRCm39) F30I probably damaging Het
Svil A G 18: 5,082,853 (GRCm39) E748G probably damaging Het
Swap70 T A 7: 109,869,126 (GRCm39) H306Q probably benign Het
Try10 G A 6: 41,334,755 (GRCm39) G227D probably damaging Het
Ttn T C 2: 76,726,713 (GRCm39) probably benign Het
Ttn T A 2: 76,749,436 (GRCm39) H3871L probably benign Het
Vmn1r231 T C 17: 21,110,745 (GRCm39) I57V possibly damaging Het
Vpreb1a A G 16: 16,686,666 (GRCm39) S75P probably damaging Het
Zkscan5 A G 5: 145,157,894 (GRCm39) probably null Het
Other mutations in Stk19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02192:Stk19 APN 17 35,051,134 (GRCm39) unclassified probably benign
R0087:Stk19 UTSW 17 35,055,851 (GRCm39) start codon destroyed probably null 0.53
R1613:Stk19 UTSW 17 35,043,574 (GRCm39) missense probably damaging 0.99
R2166:Stk19 UTSW 17 35,051,486 (GRCm39) missense possibly damaging 0.77
R3946:Stk19 UTSW 17 35,043,723 (GRCm39) splice site probably benign
R4510:Stk19 UTSW 17 35,051,504 (GRCm39) missense probably damaging 0.97
R4511:Stk19 UTSW 17 35,051,504 (GRCm39) missense probably damaging 0.97
R4721:Stk19 UTSW 17 35,042,120 (GRCm39) splice site probably null
R4798:Stk19 UTSW 17 35,041,485 (GRCm39) unclassified probably benign
R5225:Stk19 UTSW 17 35,040,400 (GRCm39) unclassified probably benign
R5244:Stk19 UTSW 17 35,051,046 (GRCm39) missense probably damaging 1.00
R5594:Stk19 UTSW 17 35,039,538 (GRCm39) unclassified probably benign
R6332:Stk19 UTSW 17 35,043,574 (GRCm39) missense probably damaging 0.99
R7529:Stk19 UTSW 17 35,043,632 (GRCm39) missense probably benign 0.03
R8440:Stk19 UTSW 17 35,055,456 (GRCm39) missense possibly damaging 0.89
R9261:Stk19 UTSW 17 35,051,432 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- AGCTCTGACAAGGCAAGCTC -3'
(R):5'- GTAGCCTCTACATGCTTGTGTAC -3'

Sequencing Primer
(F):5'- AAGGCAAGCTCCCGGTACTTG -3'
(R):5'- GTGTACCTGCCCAGACAGTATATG -3'
Posted On 2019-01-31