Incidental Mutation 'PIT4495001:Or1o3'
ID 555982
Institutional Source Beutler Lab
Gene Symbol Or1o3
Ensembl Gene ENSMUSG00000063660
Gene Name olfactory receptor family 1 subfamily O member 3
Synonyms Olfr98, GA_x6K02T2PSCP-1703582-1702653, MOR156-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # PIT4495001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37573624-37574553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 37573721 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 278 (V278G)
Ref Sequence ENSEMBL: ENSMUSP00000094936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080759]
AlphaFold Q8VFD9
Predicted Effect possibly damaging
Transcript: ENSMUST00000080759
AA Change: V278G

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000094936
Gene: ENSMUSG00000063660
AA Change: V278G

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 9.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.9e-5 PFAM
Pfam:7tm_1 38 287 2.4e-20 PFAM
Coding Region Coverage
  • 1x: 93.1%
  • 3x: 90.6%
  • 10x: 84.0%
  • 20x: 69.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl2 T A 1: 156,460,755 (GRCm39) V384D probably damaging Het
Adamts7 A G 9: 90,056,675 (GRCm39) E248G probably damaging Het
Aff1 A G 5: 103,997,391 (GRCm39) T1162A probably benign Het
Ank3 C A 10: 69,828,902 (GRCm39) H2524N Het
Aoc1l3 A T 6: 48,964,710 (GRCm39) E239D possibly damaging Het
Cct7 T A 6: 85,436,943 (GRCm39) N60K probably damaging Het
Cfap43 A C 19: 47,885,741 (GRCm39) C291W probably damaging Het
Cobl G A 11: 12,204,596 (GRCm39) T702I probably benign Het
Col5a1 C A 2: 27,914,788 (GRCm39) Q1624K unknown Het
Cubn T A 2: 13,496,561 (GRCm39) T22S probably benign Het
Def8 A C 8: 124,186,292 (GRCm39) M344L probably benign Het
Fzd7 A G 1: 59,523,466 (GRCm39) T450A probably benign Het
Gm11214 G A 4: 63,580,922 (GRCm39) L76F probably benign Het
Gm5797 T C 14: 7,329,530 (GRCm38) T153A probably benign Het
Gsk3a A C 7: 24,935,064 (GRCm39) S129A probably damaging Het
Intu A G 3: 40,652,033 (GRCm39) Q830R probably benign Het
Kcnma1 C T 14: 23,475,665 (GRCm39) V750I probably benign Het
Mlh1 T A 9: 111,076,328 (GRCm39) Y343F probably benign Het
Myb C T 10: 21,028,521 (GRCm39) R114H probably damaging Het
Neb A T 2: 52,102,748 (GRCm39) D4508E probably benign Het
Nell2 T C 15: 95,281,608 (GRCm39) D366G probably benign Het
Or4d6 A G 19: 12,086,076 (GRCm39) I52T possibly damaging Het
Or5ac25 A C 16: 59,181,871 (GRCm39) F237V probably damaging Het
Or5h26 G T 16: 58,988,337 (GRCm39) H56Q possibly damaging Het
Or7a38 T C 10: 78,752,821 (GRCm39) V49A probably benign Het
Pcdhgc5 C T 18: 37,954,030 (GRCm39) H435Y possibly damaging Het
Pira12 A T 7: 3,900,457 (GRCm39) C98S probably damaging Het
Pnpla7 T A 2: 24,932,151 (GRCm39) D935E probably damaging Het
Pole A G 5: 110,451,780 (GRCm39) E874G probably damaging Het
Psd3 A C 8: 68,416,565 (GRCm39) I158R probably benign Het
Pzp C A 6: 128,479,192 (GRCm39) V654L probably benign Het
Rabep1 A G 11: 70,808,405 (GRCm39) T454A probably damaging Het
Rad54l2 C A 9: 106,593,343 (GRCm39) S419I probably benign Het
Rin3 A G 12: 102,335,295 (GRCm39) D402G probably benign Het
Ripk4 T C 16: 97,544,370 (GRCm39) H759R probably damaging Het
Rlig1 A T 10: 100,419,812 (GRCm39) F90I probably damaging Het
Sbsn GAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCA GAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCA 7: 30,452,391 (GRCm39) probably benign Het
Sf3a3 C T 4: 124,622,113 (GRCm39) P391L probably damaging Het
Snx9 T A 17: 5,970,401 (GRCm39) I379K possibly damaging Het
Syt5 A C 7: 4,544,077 (GRCm39) probably null Het
Tex47 A G 5: 7,355,011 (GRCm39) D64G probably benign Het
Zbbx C A 3: 74,968,944 (GRCm39) W509L probably damaging Het
Zer1 T C 2: 29,993,555 (GRCm39) K551R probably benign Het
Other mutations in Or1o3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02402:Or1o3 APN 17 37,574,111 (GRCm39) missense possibly damaging 0.46
R0574:Or1o3 UTSW 17 37,573,772 (GRCm39) missense probably damaging 1.00
R1490:Or1o3 UTSW 17 37,573,733 (GRCm39) missense probably benign 0.00
R1633:Or1o3 UTSW 17 37,574,553 (GRCm39) start codon destroyed probably benign 0.02
R2105:Or1o3 UTSW 17 37,573,964 (GRCm39) missense probably benign 0.26
R4996:Or1o3 UTSW 17 37,573,758 (GRCm39) missense probably benign 0.02
R5114:Or1o3 UTSW 17 37,573,730 (GRCm39) missense probably damaging 1.00
R5225:Or1o3 UTSW 17 37,573,919 (GRCm39) missense probably benign 0.30
R5338:Or1o3 UTSW 17 37,574,532 (GRCm39) missense probably benign 0.00
R5995:Or1o3 UTSW 17 37,574,539 (GRCm39) missense probably benign 0.01
R6190:Or1o3 UTSW 17 37,573,635 (GRCm39) missense probably benign 0.00
R7006:Or1o3 UTSW 17 37,573,625 (GRCm39) makesense probably null
R7246:Or1o3 UTSW 17 37,573,905 (GRCm39) missense probably benign 0.00
R7261:Or1o3 UTSW 17 37,574,076 (GRCm39) missense probably benign
R7611:Or1o3 UTSW 17 37,573,745 (GRCm39) missense probably benign 0.02
R7642:Or1o3 UTSW 17 37,573,964 (GRCm39) missense probably benign 0.26
R8837:Or1o3 UTSW 17 37,573,807 (GRCm39) nonsense probably null
R9528:Or1o3 UTSW 17 37,574,087 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- CATGTAATTCTCCCATGAGCCATG -3'
(R):5'- TGAGTGGACTTTTAGCAATCAGTG -3'

Sequencing Primer
(F):5'- GAGCCATGGTATTAACTGACTCAC -3'
(R):5'- TGCATTTCTCTGCATTGTAAGTTC -3'
Posted On 2019-06-07