Incidental Mutation 'IGL01462:Tada1'
ID 88025
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tada1
Ensembl Gene ENSMUSG00000026563
Gene Name transcriptional adaptor 1
Synonyms Tada1l, 2900026B15Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01462
Quality Score
Status
Chromosome 1
Chromosomal Location 166206736-166221190 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 166216294 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 165 (D165G)
Ref Sequence ENSEMBL: ENSMUSP00000027846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027846] [ENSMUST00000131487] [ENSMUST00000135673] [ENSMUST00000169324]
AlphaFold Q99LM9
Predicted Effect probably damaging
Transcript: ENSMUST00000027846
AA Change: D165G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027846
Gene: ENSMUSG00000026563
AA Change: D165G

DomainStartEndE-ValueType
Pfam:SAGA-Tad1 6 131 3.2e-18 PFAM
Pfam:SAGA-Tad1 116 194 4.8e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131487
SMART Domains Protein: ENSMUSP00000116477
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
KRAB 47 107 1.53e-19 SMART
Pfam:BrkDBD 195 247 2.1e-29 PFAM
CENPB 256 323 3.93e-21 SMART
Pfam:DDE_1 355 567 1.4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135673
SMART Domains Protein: ENSMUSP00000120352
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
KRAB 47 107 1.53e-19 SMART
Pfam:BrkDBD 195 247 2.1e-29 PFAM
CENPB 256 323 3.93e-21 SMART
Pfam:DDE_1 355 567 1.4e-55 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138148
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138284
Predicted Effect probably benign
Transcript: ENSMUST00000169324
SMART Domains Protein: ENSMUSP00000127395
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 6 18 N/A INTRINSIC
low complexity region 31 46 N/A INTRINSIC
KRAB 66 126 1.53e-19 SMART
Pfam:BrkDBD 214 266 8.7e-29 PFAM
CENPB 275 342 3.93e-21 SMART
Pfam:DDE_1 414 586 1.5e-48 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 C A 6: 92,871,247 (GRCm39) A30S probably benign Het
Aspg A G 12: 112,089,387 (GRCm39) T392A probably benign Het
Atp8b5 C A 4: 43,368,010 (GRCm39) Q878K possibly damaging Het
Ccdc85a G T 11: 28,526,506 (GRCm39) H339Q probably damaging Het
Clca3a1 C T 3: 144,713,539 (GRCm39) M697I probably benign Het
Cog4 C T 8: 111,592,717 (GRCm39) T430M probably benign Het
Col6a5 A G 9: 105,823,274 (GRCm39) Y28H unknown Het
Cth A T 3: 157,610,804 (GRCm39) Y343N probably damaging Het
Dctn3 A T 4: 41,719,854 (GRCm39) L84* probably null Het
Epha5 A T 5: 84,219,092 (GRCm39) I868N probably damaging Het
Ephb2 T C 4: 136,498,681 (GRCm39) N133D possibly damaging Het
Epor G A 9: 21,870,752 (GRCm39) P376L probably damaging Het
Gsdme A G 6: 50,204,354 (GRCm39) V201A possibly damaging Het
Hdgf G A 3: 87,821,831 (GRCm39) E149K possibly damaging Het
Lrrfip2 T C 9: 111,034,917 (GRCm39) probably null Het
Ly6g6d T C 17: 35,293,226 (GRCm39) I40V probably benign Het
Mlh3 G A 12: 85,313,510 (GRCm39) T892I probably benign Het
Mmp19 C T 10: 128,634,011 (GRCm39) T304I probably damaging Het
Mmp28 T C 11: 83,334,602 (GRCm39) D384G possibly damaging Het
Moxd1 T C 10: 24,120,286 (GRCm39) probably null Het
Mtcl3 T G 10: 29,024,254 (GRCm39) L390R probably damaging Het
Ncapg T C 5: 45,828,477 (GRCm39) V76A probably benign Het
Nos1 C T 5: 118,005,774 (GRCm39) R165C probably benign Het
Or1e1c T C 11: 73,265,578 (GRCm39) M1T probably null Het
Or2a57 A G 6: 43,212,559 (GRCm39) T6A possibly damaging Het
Pik3c2a T A 7: 115,975,485 (GRCm39) H694L possibly damaging Het
Psme2 A G 14: 55,827,128 (GRCm39) L60P probably damaging Het
Ptpn23 A G 9: 110,237,175 (GRCm39) V4A probably benign Het
Rgr G T 14: 36,766,566 (GRCm39) T160K probably damaging Het
Serpind1 A G 16: 17,154,787 (GRCm39) I205V probably benign Het
Skap2 T C 6: 51,898,280 (GRCm39) Y150C probably damaging Het
Srsf9 T C 5: 115,470,187 (GRCm39) S122P probably damaging Het
Stox1 T G 10: 62,500,461 (GRCm39) I700L probably benign Het
Traf5 A G 1: 191,731,828 (GRCm39) S338P probably benign Het
Trim39 G A 17: 36,574,617 (GRCm39) probably benign Het
Wbp2 G A 11: 115,972,066 (GRCm39) A130V possibly damaging Het
Zcchc17 T C 4: 130,230,902 (GRCm39) K96E probably benign Het
Zfp800 G A 6: 28,242,983 (GRCm39) L661F possibly damaging Het
Other mutations in Tada1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02458:Tada1 APN 1 166,220,203 (GRCm39) missense probably damaging 0.99
R0959:Tada1 UTSW 1 166,216,198 (GRCm39) missense probably benign 0.13
R1442:Tada1 UTSW 1 166,214,319 (GRCm39) missense possibly damaging 0.90
R1586:Tada1 UTSW 1 166,214,319 (GRCm39) missense possibly damaging 0.90
R4790:Tada1 UTSW 1 166,219,523 (GRCm39) missense possibly damaging 0.87
R5344:Tada1 UTSW 1 166,207,081 (GRCm39) intron probably benign
R6782:Tada1 UTSW 1 166,217,541 (GRCm39) missense probably benign 0.25
R7254:Tada1 UTSW 1 166,216,217 (GRCm39) nonsense probably null
R7679:Tada1 UTSW 1 166,219,540 (GRCm39) missense probably benign
R7733:Tada1 UTSW 1 166,217,511 (GRCm39) missense probably damaging 0.99
R7831:Tada1 UTSW 1 166,217,442 (GRCm39) missense probably damaging 1.00
R9140:Tada1 UTSW 1 166,216,177 (GRCm39) missense probably benign 0.38
R9175:Tada1 UTSW 1 166,210,005 (GRCm39) missense probably damaging 0.98
R9657:Tada1 UTSW 1 166,214,312 (GRCm39) missense possibly damaging 0.69
Posted On 2013-11-18