Incidental Mutation 'R1025:Cebpzos'
ID 94932
Institutional Source Beutler Lab
Gene Symbol Cebpzos
Ensembl Gene ENSMUSG00000062691
Gene Name CCAAT/enhancer binding protein zeta, opposite strand
Synonyms 1110001A16Rik
MMRRC Submission 039127-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.724) question?
Stock # R1025 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 79223929-79227735 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 79225817 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 11 (K11E)
Ref Sequence ENSEMBL: ENSMUSP00000136411 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024885] [ENSMUST00000063817] [ENSMUST00000180077] [ENSMUST00000192288]
AlphaFold Q8BTE5
Predicted Effect probably benign
Transcript: ENSMUST00000024885
SMART Domains Protein: ENSMUSP00000024885
Gene: ENSMUSG00000024081

DomainStartEndE-ValueType
low complexity region 23 36 N/A INTRINSIC
coiled coil region 113 143 N/A INTRINSIC
Pfam:CBF 523 732 5.7e-58 PFAM
low complexity region 834 851 N/A INTRINSIC
low complexity region 881 904 N/A INTRINSIC
low complexity region 957 969 N/A INTRINSIC
low complexity region 1028 1042 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000063817
AA Change: K11E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000068772
Gene: ENSMUSG00000062691
AA Change: K11E

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000180077
AA Change: K11E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000136411
Gene: ENSMUSG00000062691
AA Change: K11E

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000192288
AA Change: K11E
Meta Mutation Damage Score 0.1817 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700067P10Rik A T 17: 48,401,030 (GRCm39) K105M probably damaging Het
3110009E18Rik C T 1: 120,099,192 (GRCm39) T95I probably damaging Het
Acte1 A G 7: 143,450,127 (GRCm39) Y291C probably damaging Het
Alyref C G 11: 120,486,758 (GRCm39) V168L probably damaging Het
Ap1g1 G A 8: 110,545,571 (GRCm39) A75T probably benign Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Baz2b T C 2: 59,792,826 (GRCm39) N434S probably benign Het
Cers1 A T 8: 70,774,186 (GRCm39) I148F probably benign Het
Cpne4 A T 9: 104,871,057 (GRCm39) I300F possibly damaging Het
Fsip2 C A 2: 82,819,780 (GRCm39) S5171* probably null Het
Gabra2 T C 5: 71,130,938 (GRCm39) S297G probably damaging Het
Irak3 A T 10: 120,012,251 (GRCm39) I171N probably damaging Het
Lama1 A G 17: 68,059,893 (GRCm39) I661V probably benign Het
Macf1 T C 4: 123,367,609 (GRCm39) D2384G probably damaging Het
Or14a260 T C 7: 85,985,113 (GRCm39) M164V probably benign Het
Or6b2b T A 1: 92,419,445 (GRCm39) T11S probably benign Het
Pdcd6ip G A 9: 113,491,354 (GRCm39) L630F probably damaging Het
Pkn2 A G 3: 142,527,326 (GRCm39) probably null Het
Slc26a4 T G 12: 31,578,736 (GRCm39) D639A probably damaging Het
Svep1 C T 4: 58,087,817 (GRCm39) C1754Y possibly damaging Het
Trpa1 C A 1: 14,974,407 (GRCm39) M258I probably benign Het
Vmn1r17 A T 6: 57,338,240 (GRCm39) S42T probably benign Het
Vmn2r57 A G 7: 41,077,228 (GRCm39) F313L probably benign Het
Zfp811 A G 17: 33,017,618 (GRCm39) Y140H probably benign Het
Other mutations in Cebpzos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00264:Cebpzos APN 17 79,225,777 (GRCm39) splice site probably benign
R1600:Cebpzos UTSW 17 79,225,817 (GRCm39) missense probably damaging 1.00
R4882:Cebpzos UTSW 17 79,227,220 (GRCm39) missense probably benign 0.00
R6326:Cebpzos UTSW 17 79,226,486 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTCCTTAGGCATGGAGATCGGAAAC -3'
(R):5'- TGCAGGTACAATAACAGCCTCGC -3'

Sequencing Primer
(F):5'- GGTTCATACAAGCACTGAGACTG -3'
(R):5'- GTCCGATACCTTCAGTCTCAAG -3'
Posted On 2014-01-05