Incidental Mutation 'R1202:Cct3'
ID 100182
Institutional Source Beutler Lab
Gene Symbol Cct3
Ensembl Gene ENSMUSG00000001416
Gene Name chaperonin containing TCP1 subunit 3
Synonyms TriC-P5, Tcp1-rs3, Cctg
MMRRC Submission 039272-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1202 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 88204442-88229073 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 88225835 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000131113 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001452] [ENSMUST00000164166] [ENSMUST00000164166] [ENSMUST00000168062]
AlphaFold P80318
Predicted Effect probably null
Transcript: ENSMUST00000001452
SMART Domains Protein: ENSMUSP00000001452
Gene: ENSMUSG00000001416

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 33 527 3.2e-171 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000163735
SMART Domains Protein: ENSMUSP00000130616
Gene: ENSMUSG00000001416

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 2 115 4.7e-22 PFAM
Pfam:Cpn60_TCP1 106 306 8.4e-64 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000163735
SMART Domains Protein: ENSMUSP00000130616
Gene: ENSMUSG00000001416

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 2 115 4.7e-22 PFAM
Pfam:Cpn60_TCP1 106 306 8.4e-64 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164122
Predicted Effect probably null
Transcript: ENSMUST00000164166
SMART Domains Protein: ENSMUSP00000126109
Gene: ENSMUSG00000001416

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 15 489 1.7e-144 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000164166
SMART Domains Protein: ENSMUSP00000126109
Gene: ENSMUSG00000001416

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 15 489 1.7e-144 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164783
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167000
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167718
Predicted Effect probably null
Transcript: ENSMUST00000168062
SMART Domains Protein: ENSMUSP00000131113
Gene: ENSMUSG00000001416

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 33 520 2.3e-157 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168971
SMART Domains Protein: ENSMUSP00000131250
Gene: ENSMUSG00000001416

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 1 38 5.6e-8 PFAM
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.8%
  • 10x: 94.6%
  • 20x: 86.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a transgenic gene disruption may exhibit lethality at E8. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm1 T C 4: 144,250,236 (GRCm39) F137L probably benign Het
Fermt3 A G 19: 6,980,850 (GRCm39) F294L probably damaging Het
Fmn2 A T 1: 174,440,101 (GRCm39) K58* probably null Het
Fndc5 G A 4: 129,033,238 (GRCm39) V102M probably damaging Het
Gle1 C T 2: 29,839,277 (GRCm39) A523V probably damaging Het
Hoxd11 C T 2: 74,512,921 (GRCm39) A62V possibly damaging Het
Il23r A G 6: 67,455,937 (GRCm39) V177A possibly damaging Het
Impdh2 G A 9: 108,440,386 (GRCm39) R224Q probably damaging Het
Larp4b A G 13: 9,216,362 (GRCm39) T516A possibly damaging Het
Mtmr2 T C 9: 13,714,748 (GRCm39) Y431H probably benign Het
N4bp1 T C 8: 87,571,515 (GRCm39) T828A probably benign Het
Nphp4 G A 4: 152,573,186 (GRCm39) probably null Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Pabpc1l G T 2: 163,879,091 (GRCm39) V313F possibly damaging Het
Pacs1 G A 19: 5,185,265 (GRCm39) P885S probably damaging Het
Scn3a T C 2: 65,336,491 (GRCm39) N705S probably benign Het
Sema4g G T 19: 44,986,696 (GRCm39) R383L probably benign Het
Slc26a10 A G 10: 127,009,217 (GRCm39) L648P probably damaging Het
St8sia2 A T 7: 73,621,783 (GRCm39) V37E probably benign Het
Tmem209 C G 6: 30,508,789 (GRCm39) V6L probably benign Het
Tmprss11a T A 5: 86,559,784 (GRCm39) probably null Het
Ube2o C T 11: 116,432,408 (GRCm39) D853N probably damaging Het
Usp17lb G A 7: 104,491,695 (GRCm39) S6F probably damaging Het
Vmn2r74 G A 7: 85,610,545 (GRCm39) T49I possibly damaging Het
Zfp236 T A 18: 82,646,291 (GRCm39) T1041S probably benign Het
Other mutations in Cct3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0068:Cct3 UTSW 3 88,225,772 (GRCm39) missense probably benign 0.05
R0068:Cct3 UTSW 3 88,225,772 (GRCm39) missense probably benign 0.05
R0454:Cct3 UTSW 3 88,210,173 (GRCm39) critical splice donor site probably null
R0799:Cct3 UTSW 3 88,206,652 (GRCm39) splice site probably null
R0883:Cct3 UTSW 3 88,220,864 (GRCm39) missense probably damaging 1.00
R3889:Cct3 UTSW 3 88,228,334 (GRCm39) missense probably benign 0.00
R4766:Cct3 UTSW 3 88,219,092 (GRCm39) nonsense probably null
R5089:Cct3 UTSW 3 88,208,150 (GRCm39) missense probably damaging 1.00
R5224:Cct3 UTSW 3 88,204,532 (GRCm39) utr 5 prime probably benign
R5263:Cct3 UTSW 3 88,228,672 (GRCm39) critical splice donor site probably null
R5772:Cct3 UTSW 3 88,208,274 (GRCm39) missense probably damaging 1.00
R6026:Cct3 UTSW 3 88,219,029 (GRCm39) missense possibly damaging 0.90
R7230:Cct3 UTSW 3 88,220,567 (GRCm39) missense probably damaging 0.99
R7423:Cct3 UTSW 3 88,216,503 (GRCm39) missense probably benign 0.05
R7810:Cct3 UTSW 3 88,228,442 (GRCm39) missense probably damaging 1.00
R8315:Cct3 UTSW 3 88,220,564 (GRCm39) missense probably benign 0.00
R8422:Cct3 UTSW 3 88,208,126 (GRCm39) missense probably damaging 1.00
R8431:Cct3 UTSW 3 88,225,831 (GRCm39) missense possibly damaging 0.68
R9290:Cct3 UTSW 3 88,216,536 (GRCm39) missense probably benign
R9295:Cct3 UTSW 3 88,212,430 (GRCm39) missense probably benign 0.00
R9338:Cct3 UTSW 3 88,225,706 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- ACCAGTCAGTTCAGACCTCTCAGTG -3'
(R):5'- AGACATGCAGCTACAGGCCAATG -3'

Sequencing Primer
(F):5'- CACAGACTGTGGACCACTAGATG -3'
(R):5'- caatgagcatggactgaaaataaaac -3'
Posted On 2014-01-15