Incidental Mutation 'IGL01667:Zfp362'
| ID |
103346 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp362
|
| Ensembl Gene |
ENSMUSG00000028799 |
| Gene Name |
zinc finger protein 362 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.324)
|
| Stock # |
IGL01667
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
128666881-128699838 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 128680902 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 141
(L141P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128499
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071108]
[ENSMUST00000106072]
[ENSMUST00000170934]
|
| AlphaFold |
B1ASA5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071108
AA Change: L154P
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000065733
Gene: ENSMUSG00000028799
AA Change: L154P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
14 |
N/A |
INTRINSIC |
|
low complexity region
|
128 |
150 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
211 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
225 |
247 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
281 |
303 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
309 |
333 |
3.49e-5 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
369 |
391 |
7.26e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106072
AA Change: L154P
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000101686
Gene: ENSMUSG00000028799
AA Change: L154P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
14 |
N/A |
INTRINSIC |
|
low complexity region
|
128 |
150 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
211 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
225 |
247 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
281 |
303 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
309 |
333 |
3.49e-5 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
369 |
391 |
7.26e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138371
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170934
AA Change: L141P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000128499
Gene: ENSMUSG00000028799
AA Change: L141P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
115 |
137 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
198 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
212 |
234 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
240 |
262 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
268 |
290 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
296 |
320 |
3.49e-5 |
SMART |
|
ZnF_C2H2
|
326 |
348 |
1.08e-1 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap13 |
A |
G |
7: 75,219,767 (GRCm39) |
T57A |
probably damaging |
Het |
| Akna |
G |
T |
4: 63,297,396 (GRCm39) |
T886N |
probably benign |
Het |
| Aqp9 |
A |
G |
9: 71,045,495 (GRCm39) |
V38A |
probably benign |
Het |
| Awat2 |
C |
T |
X: 99,447,860 (GRCm39) |
G124D |
probably damaging |
Het |
| Camsap1 |
A |
G |
2: 25,835,293 (GRCm39) |
|
probably benign |
Het |
| Catsperg2 |
T |
C |
7: 29,409,558 (GRCm39) |
Y545C |
probably damaging |
Het |
| Cldn23 |
A |
G |
8: 36,293,074 (GRCm39) |
F138S |
possibly damaging |
Het |
| Clec4a3 |
A |
C |
6: 122,929,819 (GRCm39) |
|
probably benign |
Het |
| Dlgap3 |
C |
A |
4: 127,127,690 (GRCm39) |
T786K |
probably benign |
Het |
| Dnah2 |
A |
C |
11: 69,435,221 (GRCm39) |
S50A |
probably benign |
Het |
| Dnah2 |
A |
T |
11: 69,411,767 (GRCm39) |
I285N |
probably damaging |
Het |
| Dnah7a |
A |
G |
1: 53,586,451 (GRCm39) |
Y1467H |
probably damaging |
Het |
| Fgf22 |
C |
T |
10: 79,592,588 (GRCm39) |
P115L |
probably damaging |
Het |
| Fzd2 |
G |
T |
11: 102,496,608 (GRCm39) |
V351L |
possibly damaging |
Het |
| Gapdhs |
T |
A |
7: 30,436,062 (GRCm39) |
E174V |
possibly damaging |
Het |
| Gjc2 |
A |
C |
11: 59,068,344 (GRCm39) |
I46S |
probably damaging |
Het |
| Gm5581 |
T |
C |
6: 131,144,735 (GRCm39) |
|
noncoding transcript |
Het |
| Krt1c |
C |
A |
15: 101,724,765 (GRCm39) |
V282L |
possibly damaging |
Het |
| Myh15 |
G |
A |
16: 49,015,942 (GRCm39) |
V1873M |
probably benign |
Het |
| Myo1b |
T |
C |
1: 51,799,536 (GRCm39) |
T931A |
probably damaging |
Het |
| Myo6 |
A |
T |
9: 80,197,175 (GRCm39) |
K965N |
unknown |
Het |
| Or5a3 |
T |
C |
19: 12,400,120 (GRCm39) |
V149A |
probably benign |
Het |
| Pcnx3 |
T |
C |
19: 5,736,658 (GRCm39) |
R160G |
probably benign |
Het |
| Slc22a16 |
T |
C |
10: 40,461,014 (GRCm39) |
I272T |
probably damaging |
Het |
| Slc35b4 |
A |
G |
6: 34,144,610 (GRCm39) |
Y82H |
possibly damaging |
Het |
| Spdya |
T |
C |
17: 71,863,254 (GRCm39) |
M1T |
probably null |
Het |
| St6gal1 |
A |
G |
16: 23,140,174 (GRCm39) |
N115S |
probably benign |
Het |
| Tbc1d12 |
A |
T |
19: 38,902,744 (GRCm39) |
|
probably benign |
Het |
| Tfrc |
A |
G |
16: 32,443,261 (GRCm39) |
|
probably benign |
Het |
| Trip11 |
A |
C |
12: 101,845,121 (GRCm39) |
F1539C |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,611,422 (GRCm39) |
I15624N |
possibly damaging |
Het |
| Vmn1r169 |
A |
T |
7: 23,277,225 (GRCm39) |
M206L |
probably benign |
Het |
| Zfp692 |
A |
G |
11: 58,202,379 (GRCm39) |
H378R |
probably damaging |
Het |
| Zfp799 |
T |
C |
17: 33,040,794 (GRCm39) |
Q52R |
possibly damaging |
Het |
|
| Other mutations in Zfp362 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01939:Zfp362
|
APN |
4 |
128,680,846 (GRCm39) |
missense |
probably benign |
|
|
trek
|
UTSW |
4 |
128,679,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Zax
|
UTSW |
4 |
128,684,053 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
Zebulon
|
UTSW |
4 |
128,679,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Zfp362
|
UTSW |
4 |
128,680,993 (GRCm39) |
missense |
probably benign |
|
|
R1892:Zfp362
|
UTSW |
4 |
128,684,057 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1901:Zfp362
|
UTSW |
4 |
128,684,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2058:Zfp362
|
UTSW |
4 |
128,680,780 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3739:Zfp362
|
UTSW |
4 |
128,680,682 (GRCm39) |
splice site |
probably benign |
|
|
R6772:Zfp362
|
UTSW |
4 |
128,684,053 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6900:Zfp362
|
UTSW |
4 |
128,679,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6901:Zfp362
|
UTSW |
4 |
128,679,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7105:Zfp362
|
UTSW |
4 |
128,668,319 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7348:Zfp362
|
UTSW |
4 |
128,671,010 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7629:Zfp362
|
UTSW |
4 |
128,679,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7712:Zfp362
|
UTSW |
4 |
128,671,203 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7763:Zfp362
|
UTSW |
4 |
128,680,824 (GRCm39) |
missense |
probably benign |
|
|
R8434:Zfp362
|
UTSW |
4 |
128,679,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8508:Zfp362
|
UTSW |
4 |
128,668,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Zfp362
|
UTSW |
4 |
128,670,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Zfp362
|
UTSW |
4 |
128,688,681 (GRCm39) |
start codon destroyed |
unknown |
|
|
Z1177:Zfp362
|
UTSW |
4 |
128,668,343 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2014-01-21 |
Incidental Mutation