Incidental Mutation 'IGL00537:Zfp955b'
| ID |
15016 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp955b
|
| Ensembl Gene |
ENSMUSG00000096910 |
| Gene Name |
zinc finger protein 955B |
| Synonyms |
C430039G02Rik, A430003O12Rik, Gm4455 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
IGL00537
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
33508518-33526215 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 33521847 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 439
(F439L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097011
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099414]
|
| AlphaFold |
L7N232 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000099414
AA Change: F439L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000097011
Gene: ENSMUSG00000096910
AA Change: F439L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
70 |
3.04e-14 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
7.68e0 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
5.72e-1 |
SMART |
|
ZnF_C2H2
|
290 |
312 |
6.75e0 |
SMART |
|
ZnF_C2H2
|
318 |
340 |
5.81e-2 |
SMART |
|
ZnF_C2H2
|
346 |
368 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
374 |
396 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
402 |
424 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
430 |
452 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
458 |
480 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
486 |
508 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
514 |
536 |
6.67e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182230
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 18 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bcap29 |
C |
A |
12: 31,667,095 (GRCm39) |
E189* |
probably null |
Het |
| Chd5 |
T |
C |
4: 152,445,059 (GRCm39) |
Y347H |
probably damaging |
Het |
| Cyp2c55 |
T |
A |
19: 39,000,150 (GRCm39) |
N116K |
possibly damaging |
Het |
| Dnah5 |
T |
C |
15: 28,458,848 (GRCm39) |
|
probably null |
Het |
| Erlec1 |
C |
A |
11: 30,889,591 (GRCm39) |
V185L |
probably benign |
Het |
| Glb1l3 |
T |
A |
9: 26,740,346 (GRCm39) |
Y328F |
probably damaging |
Het |
| Gnao1 |
G |
A |
8: 94,538,308 (GRCm39) |
V50M |
probably damaging |
Het |
| Mcpt4 |
T |
C |
14: 56,298,487 (GRCm39) |
T83A |
probably benign |
Het |
| Mefv |
T |
C |
16: 3,528,824 (GRCm39) |
Y539C |
probably benign |
Het |
| Pkhd1l1 |
A |
T |
15: 44,455,388 (GRCm39) |
I4050F |
possibly damaging |
Het |
| Pkhd1l1 |
C |
T |
15: 44,363,443 (GRCm39) |
T621M |
probably benign |
Het |
| Ptprq |
A |
G |
10: 107,546,383 (GRCm39) |
S304P |
probably benign |
Het |
| Rptor |
C |
T |
11: 119,690,271 (GRCm39) |
P372L |
possibly damaging |
Het |
| Soat1 |
A |
T |
1: 156,294,300 (GRCm39) |
N13K |
probably benign |
Het |
| Sspo |
G |
A |
6: 48,475,147 (GRCm39) |
|
probably benign |
Het |
| Vps13a |
T |
A |
19: 16,657,409 (GRCm39) |
T1787S |
probably benign |
Het |
| Wfdc12 |
A |
T |
2: 164,032,387 (GRCm39) |
L18Q |
probably null |
Het |
| Zmym4 |
G |
A |
4: 126,783,851 (GRCm39) |
S1125L |
probably benign |
Het |
|
| Other mutations in Zfp955b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02073:Zfp955b
|
APN |
17 |
33,519,564 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02126:Zfp955b
|
APN |
17 |
33,521,238 (GRCm39) |
nonsense |
probably null |
|
|
IGL02237:Zfp955b
|
APN |
17 |
33,520,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02587:Zfp955b
|
APN |
17 |
33,519,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02971:Zfp955b
|
APN |
17 |
33,519,940 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03034:Zfp955b
|
APN |
17 |
33,521,142 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL03493:Zfp955b
|
APN |
17 |
33,521,519 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0269:Zfp955b
|
UTSW |
17 |
33,524,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0373:Zfp955b
|
UTSW |
17 |
33,521,496 (GRCm39) |
missense |
probably benign |
|
|
R0617:Zfp955b
|
UTSW |
17 |
33,524,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0684:Zfp955b
|
UTSW |
17 |
33,521,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1778:Zfp955b
|
UTSW |
17 |
33,521,788 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1874:Zfp955b
|
UTSW |
17 |
33,524,427 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3893:Zfp955b
|
UTSW |
17 |
33,521,968 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3938:Zfp955b
|
UTSW |
17 |
33,524,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4082:Zfp955b
|
UTSW |
17 |
33,521,129 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4672:Zfp955b
|
UTSW |
17 |
33,524,233 (GRCm39) |
unclassified |
probably benign |
|
|
R4956:Zfp955b
|
UTSW |
17 |
33,524,209 (GRCm39) |
unclassified |
probably benign |
|
|
R4998:Zfp955b
|
UTSW |
17 |
33,524,125 (GRCm39) |
unclassified |
probably benign |
|
|
R5276:Zfp955b
|
UTSW |
17 |
33,522,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5341:Zfp955b
|
UTSW |
17 |
33,524,095 (GRCm39) |
unclassified |
probably benign |
|
|
R5558:Zfp955b
|
UTSW |
17 |
33,521,161 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6086:Zfp955b
|
UTSW |
17 |
33,521,478 (GRCm39) |
missense |
probably benign |
|
|
R6170:Zfp955b
|
UTSW |
17 |
33,521,084 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6306:Zfp955b
|
UTSW |
17 |
33,522,160 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6519:Zfp955b
|
UTSW |
17 |
33,521,051 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9286:Zfp955b
|
UTSW |
17 |
33,521,683 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Posted On |
2012-12-06 |
Incidental Mutation