Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01755:Sltm'

153201

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sltm

Ensembl Gene

ENSMUSG00000032212

Gene Name

SAFB-like, transcription modulator

Synonyms

5730455C01Rik, 5730555F13Rik, 9130215G10Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.958) question?

Stock #

IGL01755

Quality Score

Status

Chromosome

Chromosomal Location

70450036-70499516 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 70491204 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149059 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049263] [ENSMUST00000213808] [ENSMUST00000216816] [ENSMUST00000217593]

AlphaFold

Q8CH25

Predicted Effect

probably null
Transcript: ENSMUST00000049263

SMART Domains

Protein: ENSMUSP00000049112
Gene: ENSMUSG00000032212

Domain	Start	End	E-Value	Type
low complexity region	2	15	N/A	INTRINSIC
SAP	22	56	2.49e-10	SMART
low complexity region	74	86	N/A	INTRINSIC
coiled coil region	152	180	N/A	INTRINSIC
low complexity region	318	330	N/A	INTRINSIC
low complexity region	352	384	N/A	INTRINSIC
RRM	385	458	2.06e-16	SMART
low complexity region	498	526	N/A	INTRINSIC
low complexity region	536	552	N/A	INTRINSIC
low complexity region	591	601	N/A	INTRINSIC
coiled coil region	635	727	N/A	INTRINSIC
low complexity region	824	853	N/A	INTRINSIC
low complexity region	979	990	N/A	INTRINSIC
low complexity region	1015	1028	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000213808

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214834

Predicted Effect

probably null
Transcript: ENSMUST00000216816

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216881

Predicted Effect

probably benign
Transcript: ENSMUST00000217593

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atf6	A	G	1: 170,616,180 (GRCm39)	I520T	possibly damaging	Het
Azgp1	A	T	5: 137,988,109 (GRCm39)	K297M	possibly damaging	Het
Cyp2e1	A	G	7: 140,354,469 (GRCm39)		probably null	Het
Dapk1	C	A	13: 60,908,989 (GRCm39)	L1201M	probably damaging	Het
Dapk1	T	A	13: 60,908,990 (GRCm39)	L1201Q	possibly damaging	Het
Insrr	A	T	3: 87,721,493 (GRCm39)	D1133V	probably damaging	Het
Kcnc4	T	C	3: 107,355,491 (GRCm39)	N319S	probably damaging	Het
Kctd1	A	G	18: 15,195,694 (GRCm39)	C310R	possibly damaging	Het
Nefl	A	G	14: 68,323,526 (GRCm39)	D384G	probably damaging	Het
Nfatc3	A	G	8: 106,854,553 (GRCm39)	N1029S	probably benign	Het
Nup107	T	C	10: 117,610,398 (GRCm39)	Y348C	probably damaging	Het
Or5b117	T	C	19: 13,431,179 (GRCm39)	K234R	probably damaging	Het
Or5w8	T	A	2: 87,687,854 (GRCm39)	C112S	possibly damaging	Het
Phf8-ps	T	A	17: 33,285,951 (GRCm39)	N284Y	probably damaging	Het
Phldb2	T	C	16: 45,645,945 (GRCm39)	E212G	probably damaging	Het
Pirb	A	T	7: 3,720,169 (GRCm39)	N401K	probably benign	Het
Plcg2	T	C	8: 118,347,980 (GRCm39)	F1183S	possibly damaging	Het
Plekhf2	A	T	4: 10,991,308 (GRCm39)	N11K	probably damaging	Het
Slc7a11	A	G	3: 50,378,516 (GRCm39)	Y241H	probably benign	Het
Taf4b	A	G	18: 15,031,042 (GRCm39)	T809A	probably benign	Het
Taf4b	C	A	18: 15,031,043 (GRCm39)	T809N	probably benign	Het
Tesk1	T	C	4: 43,445,820 (GRCm39)		probably null	Het
Tspan8	C	T	10: 115,671,203 (GRCm39)	T120M	probably damaging	Het
Ttn	T	G	2: 76,551,727 (GRCm39)	D31275A	probably damaging	Het
Vcl	C	A	14: 21,046,038 (GRCm39)	Q334K	probably damaging	Het
Zfp94	G	A	7: 24,010,906 (GRCm39)		probably benign	Het
Zkscan17	A	G	11: 59,378,241 (GRCm39)	F314S	probably damaging	Het

Other mutations in Sltm

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00577:Sltm	APN	9	70,486,624 (GRCm39)	missense	probably damaging	1.00
IGL01782:Sltm	APN	9	70,480,923 (GRCm39)	missense	probably damaging	1.00
IGL02441:Sltm	APN	9	70,494,467 (GRCm39)	missense	probably damaging	1.00
IGL02831:Sltm	APN	9	70,492,147 (GRCm39)	missense	probably damaging	1.00
IGL02947:Sltm	APN	9	70,498,946 (GRCm39)	missense	probably benign	0.05
IGL03166:Sltm	APN	9	70,450,251 (GRCm39)	missense	possibly damaging	0.87
R0288:Sltm	UTSW	9	70,486,633 (GRCm39)	missense	probably damaging	1.00
R0555:Sltm	UTSW	9	70,493,363 (GRCm39)	missense	probably damaging	1.00
R0815:Sltm	UTSW	9	70,469,190 (GRCm39)	missense	probably benign	0.04
R0863:Sltm	UTSW	9	70,469,190 (GRCm39)	missense	probably benign	0.04
R1315:Sltm	UTSW	9	70,450,347 (GRCm39)	missense	probably benign	0.13
R1533:Sltm	UTSW	9	70,493,948 (GRCm39)	missense	probably damaging	1.00
R1676:Sltm	UTSW	9	70,480,929 (GRCm39)	missense	probably damaging	1.00
R1764:Sltm	UTSW	9	70,469,082 (GRCm39)	missense	probably benign	0.00
R1845:Sltm	UTSW	9	70,450,314 (GRCm39)	missense	possibly damaging	0.60
R2049:Sltm	UTSW	9	70,488,583 (GRCm39)	missense	probably benign	0.00
R2163:Sltm	UTSW	9	70,498,964 (GRCm39)	missense	probably damaging	0.99
R3410:Sltm	UTSW	9	70,493,240 (GRCm39)	missense	probably damaging	0.97
R4323:Sltm	UTSW	9	70,487,529 (GRCm39)	missense	probably benign
R4632:Sltm	UTSW	9	70,486,651 (GRCm39)	missense	possibly damaging	0.86
R4748:Sltm	UTSW	9	70,488,647 (GRCm39)	missense	probably damaging	1.00
R4756:Sltm	UTSW	9	70,498,892 (GRCm39)	missense	possibly damaging	0.57
R4782:Sltm	UTSW	9	70,496,339 (GRCm39)	missense	probably damaging	1.00
R4799:Sltm	UTSW	9	70,496,339 (GRCm39)	missense	probably damaging	1.00
R4887:Sltm	UTSW	9	70,496,260 (GRCm39)	missense	probably damaging	1.00
R5221:Sltm	UTSW	9	70,486,685 (GRCm39)	missense	probably damaging	1.00
R5263:Sltm	UTSW	9	70,492,081 (GRCm39)	missense	unknown
R5982:Sltm	UTSW	9	70,494,086 (GRCm39)	missense	probably damaging	1.00
R6297:Sltm	UTSW	9	70,488,641 (GRCm39)	missense	probably damaging	0.99
R6456:Sltm	UTSW	9	70,450,269 (GRCm39)	missense	probably damaging	1.00
R6658:Sltm	UTSW	9	70,488,644 (GRCm39)	missense	probably damaging	1.00
R6720:Sltm	UTSW	9	70,480,992 (GRCm39)	missense	probably damaging	1.00
R6770:Sltm	UTSW	9	70,492,059 (GRCm39)	missense	unknown
R6923:Sltm	UTSW	9	70,481,892 (GRCm39)	missense	probably damaging	1.00
R7051:Sltm	UTSW	9	70,466,348 (GRCm39)	missense	probably damaging	1.00
R7166:Sltm	UTSW	9	70,492,132 (GRCm39)	missense	probably damaging	1.00
R7257:Sltm	UTSW	9	70,451,247 (GRCm39)	splice site	probably null
R7400:Sltm	UTSW	9	70,493,352 (GRCm39)	missense	probably damaging	1.00
R7438:Sltm	UTSW	9	70,480,748 (GRCm39)	missense	unknown
R7484:Sltm	UTSW	9	70,481,179 (GRCm39)	missense	unknown
R7630:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7631:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7632:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7633:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7862:Sltm	UTSW	9	70,479,446 (GRCm39)	nonsense	probably null
R7885:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7886:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7888:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7889:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7891:Sltm	UTSW	9	70,493,955 (GRCm39)	missense	possibly damaging	0.94
R7915:Sltm	UTSW	9	70,494,431 (GRCm39)	missense	probably damaging	1.00
R8030:Sltm	UTSW	9	70,493,261 (GRCm39)	nonsense	probably null
R8062:Sltm	UTSW	9	70,480,779 (GRCm39)	missense	unknown
R8099:Sltm	UTSW	9	70,493,360 (GRCm39)	missense	probably damaging	1.00
R8374:Sltm	UTSW	9	70,469,227 (GRCm39)	missense	probably null
R8698:Sltm	UTSW	9	70,494,352 (GRCm39)	missense	probably benign	0.27
R9541:Sltm	UTSW	9	70,481,057 (GRCm39)	missense	unknown
R9563:Sltm	UTSW	9	70,480,841 (GRCm39)	missense	unknown

Posted On

2014-02-04