Incidental Mutation 'R0052:Zfp14'
ID15332
Institutional Source Beutler Lab
Gene Symbol Zfp14
Ensembl Gene ENSMUSG00000053985
Gene Namezinc finger protein 14
Synonyms4732429I09Rik, Zfp-14, Krox-9
MMRRC Submission 038346-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.196) question?
Stock #R0052 (G1)
Quality Score
Status Validated
Chromosome7
Chromosomal Location30036359-30051380 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 30038328 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Lysine at position 411 (Q411K)
Ref Sequence ENSEMBL: ENSMUSP00000146824 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077787] [ENSMUST00000207072] [ENSMUST00000207873]
Predicted Effect probably damaging
Transcript: ENSMUST00000077787
AA Change: Q411K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000076960
Gene: ENSMUSG00000053985
AA Change: Q411K

DomainStartEndE-ValueType
KRAB 8 69 2.39e-21 SMART
ZnF_C2H2 140 162 8.47e-4 SMART
ZnF_C2H2 168 190 5.9e-3 SMART
ZnF_C2H2 196 218 2.75e-3 SMART
ZnF_C2H2 224 246 6.42e-4 SMART
ZnF_C2H2 252 274 1.03e-2 SMART
ZnF_C2H2 280 302 5.5e-3 SMART
ZnF_C2H2 308 330 2.02e-1 SMART
ZnF_C2H2 336 358 8.6e-5 SMART
ZnF_C2H2 364 386 4.17e-3 SMART
ZnF_C2H2 392 414 2.57e-3 SMART
ZnF_C2H2 420 442 9.44e-2 SMART
ZnF_C2H2 448 470 1.03e-2 SMART
ZnF_C2H2 476 498 5.9e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000207072
AA Change: Q411K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000207873
AA Change: Q411K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Meta Mutation Damage Score 0.052 question?
Coding Region Coverage
  • 1x: 85.5%
  • 3x: 78.2%
  • 10x: 46.7%
  • 20x: 12.5%
Validation Efficiency 90% (62/69)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apba1 T C 19: 23,915,951 S438P possibly damaging Het
Atp2a1 A G 7: 126,457,897 probably benign Het
Bicd2 T A 13: 49,375,314 L184Q probably damaging Het
Bub1 G A 2: 127,809,039 T618I probably benign Het
Dsp A G 13: 38,197,364 D2096G possibly damaging Het
Eno4 A G 19: 58,968,553 D357G probably damaging Het
Fam214a A G 9: 75,018,983 probably benign Het
Fcrls A T 3: 87,256,778 I348N possibly damaging Het
Fgl2 A T 5: 21,375,349 S230C probably damaging Het
Ginm1 T A 10: 7,779,306 E57D possibly damaging Het
Itga9 T A 9: 118,636,549 I157N probably damaging Het
Kif21a T C 15: 90,970,857 E700G probably damaging Het
Mmd C T 11: 90,259,998 probably benign Het
Morn3 T C 5: 123,046,663 Y38C probably damaging Het
Prex2 T A 1: 11,160,156 L802Q probably damaging Het
Psd3 A G 8: 67,882,979 probably null Het
Ralgds T A 2: 28,544,388 probably null Het
Rmdn2 A G 17: 79,650,331 E16G probably damaging Het
Slc17a3 C T 13: 23,855,858 S293F probably damaging Het
Slc4a4 A C 5: 89,156,336 H502P possibly damaging Het
Slco3a1 A T 7: 74,504,326 I166N probably benign Het
Snx5 A T 2: 144,259,192 probably null Het
Srgap1 T C 10: 121,800,827 D741G possibly damaging Het
St8sia2 G T 7: 73,943,290 Y339* probably null Het
Tdo2 T A 3: 81,967,025 N210I probably benign Het
Thada A T 17: 84,455,158 N104K probably damaging Het
Timm8b A T 9: 50,605,030 D61V possibly damaging Het
Trbv12-1 T C 6: 41,113,916 F74S possibly damaging Het
Tshz1 G A 18: 84,014,945 T446I possibly damaging Het
Ubap2l T C 3: 90,038,928 N123S possibly damaging Het
Usp12 A G 5: 146,739,104 V336A possibly damaging Het
Xrn2 T A 2: 147,040,965 probably benign Het
Other mutations in Zfp14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Zfp14 APN 7 30038887 nonsense probably null
IGL01018:Zfp14 APN 7 30038101 missense probably damaging 1.00
IGL01060:Zfp14 APN 7 30038085 missense probably damaging 1.00
IGL03223:Zfp14 APN 7 30038433 missense probably damaging 1.00
R0052:Zfp14 UTSW 7 30038328 missense probably damaging 0.99
R1860:Zfp14 UTSW 7 30038691 missense probably damaging 1.00
R2852:Zfp14 UTSW 7 30039171 missense probably benign 0.01
R2887:Zfp14 UTSW 7 30038765 missense probably damaging 0.98
R4585:Zfp14 UTSW 7 30038916 missense probably damaging 0.99
R4586:Zfp14 UTSW 7 30038916 missense probably damaging 0.99
R4625:Zfp14 UTSW 7 30038595 nonsense probably null
R4988:Zfp14 UTSW 7 30038057 missense probably benign
R5791:Zfp14 UTSW 7 30038262 missense probably damaging 0.99
R6709:Zfp14 UTSW 7 30038132 missense probably damaging 1.00
X0017:Zfp14 UTSW 7 30038657 missense probably damaging 0.98
Posted On2012-12-17