Incidental Mutation 'R0052:Morn3'
ID15351
Institutional Source Beutler Lab
Gene Symbol Morn3
Ensembl Gene ENSMUSG00000029477
Gene NameMORN repeat containing 3
Synonyms4930438O03Rik
MMRRC Submission 038346-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.165) question?
Stock #R0052 (G1)
Quality Score
Status Validated
Chromosome5
Chromosomal Location123035769-123047016 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 123046663 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 38 (Y38C)
Ref Sequence ENSEMBL: ENSMUSP00000122306 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031437] [ENSMUST00000045843] [ENSMUST00000132775] [ENSMUST00000145257]
Predicted Effect probably damaging
Transcript: ENSMUST00000031437
AA Change: Y38C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031437
Gene: ENSMUSG00000029477
AA Change: Y38C

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 1.15e-4 SMART
MORN 158 179 2.57e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000045843
AA Change: Y38C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000041714
Gene: ENSMUSG00000029477
AA Change: Y38C

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 2.26e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000132775
AA Change: Y38C

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000120199
Gene: ENSMUSG00000029477
AA Change: Y38C

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 2.26e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000145257
AA Change: Y38C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000122306
Gene: ENSMUSG00000029477
AA Change: Y38C

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181022
Meta Mutation Damage Score 0.61 question?
Coding Region Coverage
  • 1x: 85.5%
  • 3x: 78.2%
  • 10x: 46.7%
  • 20x: 12.5%
Validation Efficiency 90% (62/69)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apba1 T C 19: 23,915,951 S438P possibly damaging Het
Atp2a1 A G 7: 126,457,897 probably benign Het
Bicd2 T A 13: 49,375,314 L184Q probably damaging Het
Bub1 G A 2: 127,809,039 T618I probably benign Het
Dsp A G 13: 38,197,364 D2096G possibly damaging Het
Eno4 A G 19: 58,968,553 D357G probably damaging Het
Fam214a A G 9: 75,018,983 probably benign Het
Fcrls A T 3: 87,256,778 I348N possibly damaging Het
Fgl2 A T 5: 21,375,349 S230C probably damaging Het
Ginm1 T A 10: 7,779,306 E57D possibly damaging Het
Itga9 T A 9: 118,636,549 I157N probably damaging Het
Kif21a T C 15: 90,970,857 E700G probably damaging Het
Mmd C T 11: 90,259,998 probably benign Het
Prex2 T A 1: 11,160,156 L802Q probably damaging Het
Psd3 A G 8: 67,882,979 probably null Het
Ralgds T A 2: 28,544,388 probably null Het
Rmdn2 A G 17: 79,650,331 E16G probably damaging Het
Slc17a3 C T 13: 23,855,858 S293F probably damaging Het
Slc4a4 A C 5: 89,156,336 H502P possibly damaging Het
Slco3a1 A T 7: 74,504,326 I166N probably benign Het
Snx5 A T 2: 144,259,192 probably null Het
Srgap1 T C 10: 121,800,827 D741G possibly damaging Het
St8sia2 G T 7: 73,943,290 Y339* probably null Het
Tdo2 T A 3: 81,967,025 N210I probably benign Het
Thada A T 17: 84,455,158 N104K probably damaging Het
Timm8b A T 9: 50,605,030 D61V possibly damaging Het
Trbv12-1 T C 6: 41,113,916 F74S possibly damaging Het
Tshz1 G A 18: 84,014,945 T446I possibly damaging Het
Ubap2l T C 3: 90,038,928 N123S possibly damaging Het
Usp12 A G 5: 146,739,104 V336A possibly damaging Het
Xrn2 T A 2: 147,040,965 probably benign Het
Zfp14 G T 7: 30,038,328 Q411K probably damaging Het
Other mutations in Morn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01925:Morn3 APN 5 123046762 missense probably damaging 1.00
IGL02257:Morn3 APN 5 123037725 missense probably damaging 1.00
IGL02516:Morn3 APN 5 123037300 nonsense probably null
R0052:Morn3 UTSW 5 123046663 missense probably damaging 1.00
R0433:Morn3 UTSW 5 123039333 missense probably benign 0.01
R1854:Morn3 UTSW 5 123046629 critical splice donor site probably null
R4893:Morn3 UTSW 5 123037682 missense probably damaging 1.00
R5854:Morn3 UTSW 5 123041115 missense probably damaging 1.00
R5899:Morn3 UTSW 5 123041103 missense probably damaging 1.00
R5983:Morn3 UTSW 5 123037788 missense possibly damaging 0.80
R6106:Morn3 UTSW 5 123046760 missense possibly damaging 0.83
R6766:Morn3 UTSW 5 123041207 missense probably damaging 0.98
Posted On2012-12-17