Incidental Mutation 'R0052:Morn3'
| ID |
15351 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Morn3
|
| Ensembl Gene |
ENSMUSG00000029477 |
| Gene Name |
MORN repeat containing 3 |
| Synonyms |
4930438O03Rik |
| MMRRC Submission |
038346-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.125)
|
| Stock # |
R0052 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123173832-123185079 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 123184726 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 38
(Y38C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122306
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031437]
[ENSMUST00000045843]
[ENSMUST00000132775]
[ENSMUST00000145257]
|
| AlphaFold |
Q8C5T4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031437
AA Change: Y38C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000031437
Gene: ENSMUSG00000029477
AA Change: Y38C
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
1.15e-4 |
SMART |
|
MORN
|
158 |
179 |
2.57e-1 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000045843
AA Change: Y38C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000041714
Gene: ENSMUSG00000029477
AA Change: Y38C
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
2.26e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000132775
AA Change: Y38C
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000120199
Gene: ENSMUSG00000029477
AA Change: Y38C
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
2.26e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000145257
AA Change: Y38C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122306
Gene: ENSMUSG00000029477
AA Change: Y38C
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181022
|
| Meta Mutation Damage Score |
0.9482 |
| Coding Region Coverage |
- 1x: 85.5%
- 3x: 78.2%
- 10x: 46.7%
- 20x: 12.5%
|
| Validation Efficiency |
90% (62/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apba1 |
T |
C |
19: 23,893,315 (GRCm39) |
S438P |
possibly damaging |
Het |
| Atosa |
A |
G |
9: 74,926,265 (GRCm39) |
|
probably benign |
Het |
| Atp2a1 |
A |
G |
7: 126,057,069 (GRCm39) |
|
probably benign |
Het |
| Bicd2 |
T |
A |
13: 49,528,790 (GRCm39) |
L184Q |
probably damaging |
Het |
| Bub1 |
G |
A |
2: 127,650,959 (GRCm39) |
T618I |
probably benign |
Het |
| Dsp |
A |
G |
13: 38,381,340 (GRCm39) |
D2096G |
possibly damaging |
Het |
| Eno4 |
A |
G |
19: 58,956,985 (GRCm39) |
D357G |
probably damaging |
Het |
| Fcrl2 |
A |
T |
3: 87,164,085 (GRCm39) |
I348N |
possibly damaging |
Het |
| Fgl2 |
A |
T |
5: 21,580,347 (GRCm39) |
S230C |
probably damaging |
Het |
| Ginm1 |
T |
A |
10: 7,655,070 (GRCm39) |
E57D |
possibly damaging |
Het |
| Itga9 |
T |
A |
9: 118,465,617 (GRCm39) |
I157N |
probably damaging |
Het |
| Kif21a |
T |
C |
15: 90,855,060 (GRCm39) |
E700G |
probably damaging |
Het |
| Mmd |
C |
T |
11: 90,150,824 (GRCm39) |
|
probably benign |
Het |
| Prex2 |
T |
A |
1: 11,230,380 (GRCm39) |
L802Q |
probably damaging |
Het |
| Psd3 |
A |
G |
8: 68,335,631 (GRCm39) |
|
probably null |
Het |
| Ralgds |
T |
A |
2: 28,434,400 (GRCm39) |
|
probably null |
Het |
| Rmdn2 |
A |
G |
17: 79,957,760 (GRCm39) |
E16G |
probably damaging |
Het |
| Slc17a3 |
C |
T |
13: 24,039,841 (GRCm39) |
S293F |
probably damaging |
Het |
| Slc4a4 |
A |
C |
5: 89,304,195 (GRCm39) |
H502P |
possibly damaging |
Het |
| Slco3a1 |
A |
T |
7: 74,154,074 (GRCm39) |
I166N |
probably benign |
Het |
| Snx5 |
A |
T |
2: 144,101,112 (GRCm39) |
|
probably null |
Het |
| Srgap1 |
T |
C |
10: 121,636,732 (GRCm39) |
D741G |
possibly damaging |
Het |
| St8sia2 |
G |
T |
7: 73,593,038 (GRCm39) |
Y339* |
probably null |
Het |
| Tdo2 |
T |
A |
3: 81,874,332 (GRCm39) |
N210I |
probably benign |
Het |
| Thada |
A |
T |
17: 84,762,586 (GRCm39) |
N104K |
probably damaging |
Het |
| Timm8b |
A |
T |
9: 50,516,330 (GRCm39) |
D61V |
possibly damaging |
Het |
| Trbv12-1 |
T |
C |
6: 41,090,850 (GRCm39) |
F74S |
possibly damaging |
Het |
| Tshz1 |
G |
A |
18: 84,033,070 (GRCm39) |
T446I |
possibly damaging |
Het |
| Ubap2l |
T |
C |
3: 89,946,235 (GRCm39) |
N123S |
possibly damaging |
Het |
| Usp12 |
A |
G |
5: 146,675,914 (GRCm39) |
V336A |
possibly damaging |
Het |
| Xrn2 |
T |
A |
2: 146,882,885 (GRCm39) |
|
probably benign |
Het |
| Zfp14 |
G |
T |
7: 29,737,753 (GRCm39) |
Q411K |
probably damaging |
Het |
|
| Other mutations in Morn3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01925:Morn3
|
APN |
5 |
123,184,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02257:Morn3
|
APN |
5 |
123,175,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02516:Morn3
|
APN |
5 |
123,175,363 (GRCm39) |
nonsense |
probably null |
|
|
R0052:Morn3
|
UTSW |
5 |
123,184,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Morn3
|
UTSW |
5 |
123,177,396 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1854:Morn3
|
UTSW |
5 |
123,184,692 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4893:Morn3
|
UTSW |
5 |
123,175,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5854:Morn3
|
UTSW |
5 |
123,179,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5899:Morn3
|
UTSW |
5 |
123,179,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5983:Morn3
|
UTSW |
5 |
123,175,851 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6106:Morn3
|
UTSW |
5 |
123,184,823 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6766:Morn3
|
UTSW |
5 |
123,179,270 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7512:Morn3
|
UTSW |
5 |
123,175,343 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8722:Morn3
|
UTSW |
5 |
123,179,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8780:Morn3
|
UTSW |
5 |
123,175,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Morn3
|
UTSW |
5 |
123,175,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Morn3
|
UTSW |
5 |
123,184,783 (GRCm39) |
frame shift |
probably null |
|
|
| Posted On |
2012-12-17 |
Incidental Mutation