Incidental Mutation 'IGL01752:Cdkl4'
ID153411
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdkl4
Ensembl Gene ENSMUSG00000033966
Gene Namecyclin-dependent kinase-like 4
SynonymsLOC381113
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #IGL01752
Quality Score
Status
Chromosome17
Chromosomal Location80523550-80563834 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to A at 80543614 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000083732 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086545]
Predicted Effect probably benign
Transcript: ENSMUST00000086545
SMART Domains Protein: ENSMUSP00000083732
Gene: ENSMUSG00000033966

DomainStartEndE-ValueType
S_TKc 4 286 6.65e-102 SMART
low complexity region 295 307 N/A INTRINSIC
Meta Mutation Damage Score 0.1332 question?
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap11 A T 14: 78,509,878 probably null Het
Btbd11 C A 10: 85,654,502 Q1011K probably damaging Het
Cdh4 A T 2: 179,890,884 N713I probably damaging Het
Ddx21 A G 10: 62,587,507 S639P probably damaging Het
Dock3 T C 9: 107,025,313 probably benign Het
Fan1 G A 7: 64,372,794 T237M probably benign Het
Fbn2 T A 18: 58,075,977 probably null Het
Fhad1 T C 4: 141,972,899 K347E possibly damaging Het
Gucy2c C A 6: 136,770,108 A118S probably benign Het
Itgb4 G A 11: 115,988,926 V635I probably damaging Het
Lox A G 18: 52,520,854 V390A possibly damaging Het
Lyn A T 4: 3,743,286 M69L probably benign Het
Mrgprb5 A G 7: 48,168,667 F107L probably benign Het
Neurod2 T C 11: 98,327,375 E321G possibly damaging Het
Olfr912 C T 9: 38,581,513 P79S probably damaging Het
Pcnx3 T A 19: 5,665,337 K1962* probably null Het
Pde3a T C 6: 141,487,613 probably benign Het
Phf10 A G 17: 14,954,950 probably benign Het
Prune2 A G 19: 17,123,903 E2257G possibly damaging Het
Rock1 A G 18: 10,079,113 probably null Het
Slc4a11 T G 2: 130,688,145 T238P probably damaging Het
Ssu2 T A 6: 112,375,592 K279N probably damaging Het
Tead3 A T 17: 28,333,594 I275N probably damaging Het
Ttn T C 2: 76,744,793 E25252G probably damaging Het
Twsg1 T C 17: 65,929,784 T84A probably benign Het
Ugt3a1 A T 15: 9,306,146 K127M probably damaging Het
Unc13c A T 9: 73,931,811 M586K probably benign Het
Vmn1r195 G T 13: 22,279,251 C297F probably benign Het
Vps13c T A 9: 67,948,228 I2525N probably damaging Het
Zdhhc2 G A 8: 40,473,001 A346T probably benign Het
Zfp52 T G 17: 21,560,150 C87G probably benign Het
Other mutations in Cdkl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Cdkl4 APN 17 80525276 utr 3 prime probably benign
IGL02000:Cdkl4 APN 17 80543763 missense probably damaging 1.00
IGL02393:Cdkl4 APN 17 80560415 missense probably damaging 1.00
R0047:Cdkl4 UTSW 17 80550845 missense probably benign 0.10
R0507:Cdkl4 UTSW 17 80543808 missense probably benign 0.06
R1555:Cdkl4 UTSW 17 80543614 splice site probably benign
R1623:Cdkl4 UTSW 17 80556302 splice site probably null
R2007:Cdkl4 UTSW 17 80556301 splice site probably benign
R4701:Cdkl4 UTSW 17 80543652 missense probably damaging 0.97
R4975:Cdkl4 UTSW 17 80525335 nonsense probably null
R5246:Cdkl4 UTSW 17 80539484 intron probably null
R5708:Cdkl4 UTSW 17 80539522 missense possibly damaging 0.94
R5914:Cdkl4 UTSW 17 80547691 critical splice donor site probably null
R6464:Cdkl4 UTSW 17 80525352 missense probably benign 0.00
R6882:Cdkl4 UTSW 17 80543746 missense probably damaging 0.99
Posted On2014-02-04