Incidental Mutation 'R0042:Prr35'
ID 15451
Institutional Source Beutler Lab
Gene Symbol Prr35
Ensembl Gene ENSMUSG00000025727
Gene Name proline rich 35
Synonyms A930017K11Rik
MMRRC Submission 038336-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0042 (G1)
Quality Score
Status Validated
Chromosome 17
Chromosomal Location 26165361-26171539 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 26166956 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 194 (E194*)
Ref Sequence ENSEMBL: ENSMUSP00000125106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085027] [ENSMUST00000148307] [ENSMUST00000162431] [ENSMUST00000181174]
AlphaFold E0CXQ2
Predicted Effect probably benign
Transcript: ENSMUST00000085027
SMART Domains Protein: ENSMUSP00000082102
Gene: ENSMUSG00000090113

DomainStartEndE-ValueType
Pfam:NHL 61 88 8.4e-8 PFAM
SCOP:d1crua_ 89 129 4e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148307
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159540
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162078
Predicted Effect probably null
Transcript: ENSMUST00000162431
AA Change: E194*
SMART Domains Protein: ENSMUSP00000125106
Gene: ENSMUSG00000025727
AA Change: E194*

DomainStartEndE-ValueType
Pfam:zf-C2H2_7 17 70 4.3e-40 PFAM
low complexity region 77 90 N/A INTRINSIC
low complexity region 117 137 N/A INTRINSIC
low complexity region 158 170 N/A INTRINSIC
low complexity region 229 249 N/A INTRINSIC
low complexity region 294 311 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Predicted Effect probably benign
Transcript: ENSMUST00000181174
Meta Mutation Damage Score 0.9704 question?
Coding Region Coverage
  • 1x: 81.9%
  • 3x: 73.7%
  • 10x: 53.7%
  • 20x: 34.5%
Validation Efficiency 94% (58/62)
Allele List at MGI

All alleles(3) : Targeted(2) Gene trapped(1)
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 C T 4: 53,059,245 (GRCm39) probably benign Het
Adgrf3 A G 5: 30,402,426 (GRCm39) L534P probably damaging Het
Ank2 T C 3: 126,730,280 (GRCm39) D3568G probably damaging Het
Atr T A 9: 95,809,409 (GRCm39) probably benign Het
Ccnb2 A G 9: 70,326,335 (GRCm39) V34A probably benign Het
Dmxl1 C A 18: 49,997,102 (GRCm39) T466K probably benign Het
Eya1 T C 1: 14,254,713 (GRCm39) D373G probably damaging Het
Fam120a A G 13: 49,087,490 (GRCm39) V290A probably damaging Het
Gpr179 C T 11: 97,225,757 (GRCm39) V2133I probably benign Het
Grb10 G T 11: 11,886,798 (GRCm39) H435Q probably damaging Het
Gzmm T C 10: 79,530,399 (GRCm39) I190T probably benign Het
H2-Q3 A G 17: 35,578,823 (GRCm39) noncoding transcript Het
Hspb7 A G 4: 141,151,245 (GRCm39) E129G probably damaging Het
Il17ra T C 6: 120,449,086 (GRCm39) probably benign Het
Itgb3 A G 11: 104,557,966 (GRCm39) T787A possibly damaging Het
Krt4 T G 15: 101,831,187 (GRCm39) probably benign Het
Lgsn C T 1: 31,229,534 (GRCm39) T85I probably benign Het
Metap1 C T 3: 138,177,918 (GRCm39) V217I probably benign Het
Mib2 A T 4: 155,743,897 (GRCm39) C48* probably null Het
Mroh4 T A 15: 74,482,154 (GRCm39) I768F probably damaging Het
Npas3 T A 12: 54,095,624 (GRCm39) D361E probably damaging Het
P4hb G A 11: 120,459,092 (GRCm39) R134C probably damaging Het
Rbl1 A G 2: 157,017,624 (GRCm39) probably benign Het
Rdh10 T A 1: 16,178,260 (GRCm39) probably benign Het
Spata31 A T 13: 65,070,377 (GRCm39) I842L probably benign Het
Stk32b A C 5: 37,874,092 (GRCm39) D13E probably benign Het
Svep1 T C 4: 58,123,192 (GRCm39) D708G possibly damaging Het
Taar6 T C 10: 23,861,021 (GRCm39) D175G probably benign Het
Tmod4 T C 3: 95,037,099 (GRCm39) D164G possibly damaging Het
Ttc23l A C 15: 10,551,627 (GRCm39) L33W probably damaging Het
Ttc39d T C 17: 80,523,379 (GRCm39) Y13H probably benign Het
Utp18 G T 11: 93,766,684 (GRCm39) T309K probably damaging Het
Vps11 G T 9: 44,267,588 (GRCm39) Y341* probably null Het
Vsig8 T C 1: 172,387,925 (GRCm39) V5A possibly damaging Het
Other mutations in Prr35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02035:Prr35 APN 17 26,166,136 (GRCm39) missense probably benign 0.02
R0042:Prr35 UTSW 17 26,166,956 (GRCm39) nonsense probably null
R0558:Prr35 UTSW 17 26,166,523 (GRCm39) missense probably benign 0.00
R0856:Prr35 UTSW 17 26,167,001 (GRCm39) missense probably benign
R1623:Prr35 UTSW 17 26,166,508 (GRCm39) missense probably benign 0.01
R1830:Prr35 UTSW 17 26,165,691 (GRCm39) missense possibly damaging 0.95
R2173:Prr35 UTSW 17 26,167,461 (GRCm39) missense probably damaging 1.00
R6726:Prr35 UTSW 17 26,166,689 (GRCm39) missense probably benign 0.17
R7350:Prr35 UTSW 17 26,165,685 (GRCm39) missense probably damaging 1.00
R7369:Prr35 UTSW 17 26,166,934 (GRCm39) missense probably damaging 1.00
R7718:Prr35 UTSW 17 26,165,998 (GRCm39) nonsense probably null
R7841:Prr35 UTSW 17 26,167,458 (GRCm39) nonsense probably null
R8845:Prr35 UTSW 17 26,165,823 (GRCm39) missense probably benign 0.12
R9012:Prr35 UTSW 17 26,166,685 (GRCm39) missense probably benign
R9351:Prr35 UTSW 17 26,166,118 (GRCm39) nonsense probably null
Posted On 2012-12-21