Mutagenetix > Incidental Mutation

Incidental Mutation 'R0039:Cdk17'

15543

Institutional Source

Beutler Lab

Gene Symbol

Cdk17

Ensembl Gene

ENSMUSG00000020015

Gene Name

cyclin dependent kinase 17

Synonyms

Pctk2, 6430598J10Rik

MMRRC Submission

038333-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.295) question?

Stock #

R0039 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

92996492-93086956 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 93062640 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150873 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069965] [ENSMUST00000215286]

AlphaFold

Q8K0D0

Predicted Effect

probably benign
Transcript: ENSMUST00000069965

SMART Domains

Protein: ENSMUSP00000070355
Gene: ENSMUSG00000020015

Domain	Start	End	E-Value	Type
S_TKc	192	473	4.67e-97	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000215286

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215495

Coding Region Coverage

1x: 82.5%
3x: 74.4%
10x: 54.3%
20x: 37.4%

Validation Efficiency

95% (60/63)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap5	C	T	12: 52,565,518 (GRCm39)	Q830*	probably null	Het
Atic	A	T	1: 71,617,009 (GRCm39)	E523V	possibly damaging	Het
Cass4	T	A	2: 172,268,900 (GRCm39)	F329L	probably damaging	Het
Cep120	C	T	18: 53,819,033 (GRCm39)	R886H	probably benign	Het
Cep170	A	C	1: 176,610,061 (GRCm39)		probably null	Het
Dsg3	A	G	18: 20,654,541 (GRCm39)	K82E	probably benign	Het
Dtd1	C	T	2: 144,588,896 (GRCm39)	R185W	probably damaging	Het
Glt6d1	C	A	2: 25,684,739 (GRCm39)		probably null	Het
Hectd1	T	G	12: 51,800,608 (GRCm39)	E2070A	possibly damaging	Het
Ifit1bl2	T	A	19: 34,596,846 (GRCm39)	K257*	probably null	Het
Ighv8-5	T	A	12: 115,031,207 (GRCm39)	T111S	possibly damaging	Het
Lmtk2	G	T	5: 144,103,205 (GRCm39)	L321F	probably damaging	Het
Mcoln2	C	T	3: 145,889,316 (GRCm39)	T374M	probably damaging	Het
Mfn1	T	C	3: 32,592,416 (GRCm39)		probably benign	Het
Miox	C	T	15: 89,220,477 (GRCm39)	L189F	possibly damaging	Het
Mroh8	T	C	2: 157,071,849 (GRCm39)	H552R	possibly damaging	Het
Myh2	T	A	11: 67,069,103 (GRCm39)	L304Q	probably damaging	Het
Prune1	T	A	3: 95,169,678 (GRCm39)	T175S	probably damaging	Het
Rdh10	C	T	1: 16,199,508 (GRCm39)	T238I	probably damaging	Het
Rlf	T	A	4: 121,004,039 (GRCm39)	H1647L	possibly damaging	Het
Rreb1	C	T	13: 38,083,613 (GRCm39)	T92M	probably damaging	Het
Scn9a	A	T	2: 66,392,788 (GRCm39)	M268K	probably damaging	Het
Sec16a	A	G	2: 26,313,926 (GRCm39)	V1893A	probably benign	Het
Snd1	T	A	6: 28,745,209 (GRCm39)	L518Q	probably damaging	Het
Stat1	T	A	1: 52,179,819 (GRCm39)	V343D	probably damaging	Het
Topors	A	G	4: 40,262,772 (GRCm39)	S171P	probably damaging	Het
Tubd1	C	T	11: 86,440,221 (GRCm39)	Q82*	probably null	Het
Unc13c	A	G	9: 73,576,847 (GRCm39)		probably benign	Het
Wdr43	G	T	17: 71,960,487 (GRCm39)	G590*	probably null	Het

Other mutations in Cdk17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Cdk17	APN	10	93,062,633 (GRCm39)	missense	probably damaging	1.00
IGL00781:Cdk17	APN	10	93,068,278 (GRCm39)	missense	probably damaging	1.00
IGL01622:Cdk17	APN	10	93,074,824 (GRCm39)	unclassified	probably benign
IGL01623:Cdk17	APN	10	93,074,824 (GRCm39)	unclassified	probably benign
IGL01732:Cdk17	APN	10	93,053,907 (GRCm39)	missense	probably benign	0.01
IGL01768:Cdk17	APN	10	93,044,123 (GRCm39)	missense	probably damaging	0.99
IGL02942:Cdk17	APN	10	93,074,830 (GRCm39)	missense	probably benign
IGL03308:Cdk17	APN	10	93,057,506 (GRCm39)	critical splice donor site	probably null
delude	UTSW	10	93,053,823 (GRCm39)	splice site	probably null
Imagine	UTSW	10	93,068,277 (GRCm39)	missense	probably damaging	1.00
Magician	UTSW	10	93,064,565 (GRCm39)	missense	probably damaging	1.00
prestidigitator	UTSW	10	93,061,979 (GRCm39)	missense	probably damaging	1.00
R4436_Cdk17_536	UTSW	10	93,047,758 (GRCm39)	splice site	probably null
R0398:Cdk17	UTSW	10	93,073,702 (GRCm39)	missense	probably benign	0.01
R0432:Cdk17	UTSW	10	93,073,652 (GRCm39)	unclassified	probably benign
R0609:Cdk17	UTSW	10	93,052,334 (GRCm39)	missense	probably benign
R0781:Cdk17	UTSW	10	93,074,895 (GRCm39)	nonsense	probably null
R1110:Cdk17	UTSW	10	93,074,895 (GRCm39)	nonsense	probably null
R1604:Cdk17	UTSW	10	93,068,360 (GRCm39)	missense	probably damaging	1.00
R1674:Cdk17	UTSW	10	93,057,492 (GRCm39)	missense	probably benign	0.21
R1758:Cdk17	UTSW	10	93,044,112 (GRCm39)	missense	probably damaging	1.00
R1797:Cdk17	UTSW	10	93,044,114 (GRCm39)	missense	possibly damaging	0.76
R1864:Cdk17	UTSW	10	93,061,967 (GRCm39)	missense	probably damaging	1.00
R1924:Cdk17	UTSW	10	93,061,979 (GRCm39)	missense	probably damaging	1.00
R1929:Cdk17	UTSW	10	93,064,540 (GRCm39)	missense	probably damaging	1.00
R2143:Cdk17	UTSW	10	93,053,881 (GRCm39)	missense	probably damaging	1.00
R2207:Cdk17	UTSW	10	93,064,624 (GRCm39)	missense	probably damaging	1.00
R2261:Cdk17	UTSW	10	93,047,820 (GRCm39)	missense	possibly damaging	0.90
R2262:Cdk17	UTSW	10	93,047,820 (GRCm39)	missense	possibly damaging	0.90
R3737:Cdk17	UTSW	10	93,057,506 (GRCm39)	critical splice donor site	probably null
R3883:Cdk17	UTSW	10	93,047,939 (GRCm39)	critical splice donor site	probably null
R4436:Cdk17	UTSW	10	93,047,758 (GRCm39)	splice site	probably null
R5372:Cdk17	UTSW	10	93,061,901 (GRCm39)	missense	probably benign	0.03
R5444:Cdk17	UTSW	10	93,053,823 (GRCm39)	splice site	probably null
R5488:Cdk17	UTSW	10	93,068,274 (GRCm39)	missense	probably damaging	1.00
R5489:Cdk17	UTSW	10	93,068,274 (GRCm39)	missense	probably damaging	1.00
R5815:Cdk17	UTSW	10	93,064,559 (GRCm39)	missense	probably damaging	1.00
R6164:Cdk17	UTSW	10	93,071,331 (GRCm39)	missense	probably benign	0.26
R6209:Cdk17	UTSW	10	93,044,093 (GRCm39)	missense	probably benign	0.05
R6384:Cdk17	UTSW	10	93,047,827 (GRCm39)	missense	probably damaging	0.99
R6627:Cdk17	UTSW	10	93,068,274 (GRCm39)	missense	probably damaging	1.00
R6698:Cdk17	UTSW	10	93,064,540 (GRCm39)	missense	probably damaging	1.00
R7164:Cdk17	UTSW	10	93,068,343 (GRCm39)	missense	probably benign	0.07
R8096:Cdk17	UTSW	10	93,052,229 (GRCm39)	missense	probably damaging	0.98
R8118:Cdk17	UTSW	10	93,052,252 (GRCm39)	missense	possibly damaging	0.46
R8459:Cdk17	UTSW	10	93,068,289 (GRCm39)	missense	probably damaging	0.99
R8670:Cdk17	UTSW	10	93,061,958 (GRCm39)	nonsense	probably null
R8722:Cdk17	UTSW	10	93,064,565 (GRCm39)	missense	probably damaging	1.00
R8829:Cdk17	UTSW	10	93,042,920 (GRCm39)	unclassified	probably benign
R9077:Cdk17	UTSW	10	93,068,277 (GRCm39)	missense	probably damaging	1.00
R9488:Cdk17	UTSW	10	93,044,066 (GRCm39)	missense	probably damaging	0.98
R9789:Cdk17	UTSW	10	93,060,891 (GRCm39)	missense	probably damaging	0.98

Posted On

2012-12-21