Incidental Mutation 'IGL01882:Ifna2'
| ID |
179042 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ifna2
|
| Ensembl Gene |
ENSMUSG00000078354 |
| Gene Name |
interferon alpha 2 |
| Synonyms |
Ifa2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.065)
|
| Stock # |
IGL01882
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
88601444-88602016 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 88601979 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 13
(V13A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000100778
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105147]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105147
AA Change: V13A
PolyPhen 2
Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000100778
Gene: ENSMUSG00000078354
AA Change: V13A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IFabd
|
58 |
175 |
1.24e-70 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 13 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm3 |
T |
C |
7: 119,373,858 (GRCm39) |
L248S |
probably damaging |
Het |
| Arhgef17 |
A |
T |
7: 100,527,787 (GRCm39) |
C734* |
probably null |
Het |
| Bcat1 |
G |
A |
6: 144,950,135 (GRCm39) |
T354M |
probably damaging |
Het |
| Fancd2 |
T |
C |
6: 113,523,601 (GRCm39) |
V246A |
probably benign |
Het |
| Gm10717 |
C |
T |
9: 3,025,616 (GRCm39) |
S67L |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Gm3696 |
G |
T |
14: 18,433,062 (GRCm39) |
Q199K |
probably benign |
Het |
| Letm1 |
A |
G |
5: 33,927,009 (GRCm39) |
V96A |
probably benign |
Het |
| Mcm3ap |
A |
G |
10: 76,319,018 (GRCm39) |
I749V |
possibly damaging |
Het |
| Mkln1 |
A |
G |
6: 31,428,469 (GRCm39) |
N266S |
probably benign |
Het |
| Or8b35 |
A |
G |
9: 37,903,856 (GRCm39) |
T18A |
probably damaging |
Het |
| Pdia4 |
A |
G |
6: 47,780,412 (GRCm39) |
L307P |
probably benign |
Het |
| Ptprz1 |
C |
T |
6: 23,000,463 (GRCm39) |
P851L |
probably damaging |
Het |
|
| Other mutations in Ifna2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03247:Ifna2
|
APN |
4 |
88,601,614 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4687001:Ifna2
|
UTSW |
4 |
88,601,542 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0691:Ifna2
|
UTSW |
4 |
88,601,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1305:Ifna2
|
UTSW |
4 |
88,601,614 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6470:Ifna2
|
UTSW |
4 |
88,601,751 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7886:Ifna2
|
UTSW |
4 |
88,601,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8560:Ifna2
|
UTSW |
4 |
88,601,502 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8931:Ifna2
|
UTSW |
4 |
88,601,712 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9037:Ifna2
|
UTSW |
4 |
88,601,664 (GRCm39) |
missense |
probably benign |
0.11 |
|
X0013:Ifna2
|
UTSW |
4 |
88,601,771 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation