Incidental Mutation 'IGL01915:Or6c210'
| ID |
179895 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or6c210
|
| Ensembl Gene |
ENSMUSG00000108114 |
| Gene Name |
olfactory receptor family 6 subfamily C member 210 |
| Synonyms |
GA_x6K02T2PULF-11338429-11339364, MOR114-7, Olfr800 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.202)
|
| Stock # |
IGL01915
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
129495677-129496612 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 129496519 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 281
(M281I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151047
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000104903]
[ENSMUST00000217094]
|
| AlphaFold |
Q8VFH7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000104903
AA Change: M281I
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000100499
Gene: ENSMUSG00000108114
AA Change: M281I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
28 |
307 |
7.3e-43 |
PFAM |
|
Pfam:7tm_1
|
38 |
287 |
6.9e-23 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000217094
AA Change: M281I
PolyPhen 2
Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abt1 |
T |
C |
13: 23,607,938 (GRCm39) |
E22G |
unknown |
Het |
| Aoc1l2 |
T |
A |
6: 48,908,582 (GRCm39) |
D527E |
probably damaging |
Het |
| Atp11b |
T |
G |
3: 35,885,612 (GRCm39) |
H668Q |
probably damaging |
Het |
| Birc6 |
T |
A |
17: 74,938,715 (GRCm39) |
V2687D |
probably benign |
Het |
| Cadm3 |
T |
C |
1: 173,168,675 (GRCm39) |
T298A |
possibly damaging |
Het |
| Car12 |
G |
A |
9: 66,670,552 (GRCm39) |
A174T |
possibly damaging |
Het |
| Ccdc180 |
T |
C |
4: 45,904,544 (GRCm39) |
L380P |
probably damaging |
Het |
| Col7a1 |
A |
T |
9: 108,784,813 (GRCm39) |
R214W |
unknown |
Het |
| Cyp2d26 |
T |
G |
15: 82,674,450 (GRCm39) |
R477S |
probably benign |
Het |
| Dgkd |
T |
C |
1: 87,853,780 (GRCm39) |
V541A |
possibly damaging |
Het |
| Dip2b |
T |
A |
15: 100,076,392 (GRCm39) |
F797I |
probably damaging |
Het |
| Dot1l |
A |
T |
10: 80,616,728 (GRCm39) |
N63I |
probably damaging |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Ints5 |
T |
C |
19: 8,874,357 (GRCm39) |
I772T |
probably benign |
Het |
| Nosip |
T |
A |
7: 44,726,283 (GRCm39) |
I230N |
probably damaging |
Het |
| Or2r3 |
A |
T |
6: 42,448,223 (GRCm39) |
D296E |
probably benign |
Het |
| Or4d11 |
A |
T |
19: 12,013,461 (GRCm39) |
L215Q |
probably damaging |
Het |
| Or5ac22 |
T |
A |
16: 59,135,473 (GRCm39) |
Q99L |
probably damaging |
Het |
| Orc5 |
A |
T |
5: 22,727,381 (GRCm39) |
|
probably benign |
Het |
| Parp1 |
A |
G |
1: 180,425,907 (GRCm39) |
I879M |
probably damaging |
Het |
| Pcdh18 |
A |
G |
3: 49,699,370 (GRCm39) |
S1031P |
probably benign |
Het |
| Pdzd2 |
A |
G |
15: 12,371,725 (GRCm39) |
S2557P |
probably damaging |
Het |
| Rccd1 |
T |
C |
7: 79,969,966 (GRCm39) |
|
probably benign |
Het |
| Rsad1 |
A |
G |
11: 94,439,803 (GRCm39) |
|
probably null |
Het |
| Samd9l |
A |
T |
6: 3,373,864 (GRCm39) |
C1132* |
probably null |
Het |
| Sema6d |
A |
G |
2: 124,500,491 (GRCm39) |
|
probably benign |
Het |
| Slc10a5 |
T |
C |
3: 10,400,580 (GRCm39) |
N27D |
probably damaging |
Het |
| Slco1a5 |
C |
T |
6: 142,189,599 (GRCm39) |
M462I |
probably benign |
Het |
| Tyw5 |
T |
C |
1: 57,440,628 (GRCm39) |
T45A |
probably damaging |
Het |
| Usp21 |
T |
A |
1: 171,110,307 (GRCm39) |
Q489L |
possibly damaging |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r20 |
A |
G |
6: 123,370,924 (GRCm39) |
S519P |
possibly damaging |
Het |
|
| Other mutations in Or6c210 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01322:Or6c210
|
APN |
10 |
129,495,995 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02458:Or6c210
|
APN |
10 |
129,496,475 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02721:Or6c210
|
APN |
10 |
129,495,824 (GRCm39) |
missense |
probably benign |
|
|
R0032:Or6c210
|
UTSW |
10 |
129,496,269 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0442:Or6c210
|
UTSW |
10 |
129,495,693 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1564:Or6c210
|
UTSW |
10 |
129,495,884 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1580:Or6c210
|
UTSW |
10 |
129,496,184 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1593:Or6c210
|
UTSW |
10 |
129,496,094 (GRCm39) |
nonsense |
probably null |
|
|
R1911:Or6c210
|
UTSW |
10 |
129,495,981 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2001:Or6c210
|
UTSW |
10 |
129,496,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2223:Or6c210
|
UTSW |
10 |
129,495,678 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R3876:Or6c210
|
UTSW |
10 |
129,496,143 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3884:Or6c210
|
UTSW |
10 |
129,496,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4366:Or6c210
|
UTSW |
10 |
129,496,400 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4689:Or6c210
|
UTSW |
10 |
129,496,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4909:Or6c210
|
UTSW |
10 |
129,496,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5638:Or6c210
|
UTSW |
10 |
129,495,969 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5835:Or6c210
|
UTSW |
10 |
129,495,803 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5838:Or6c210
|
UTSW |
10 |
129,495,907 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6150:Or6c210
|
UTSW |
10 |
129,495,803 (GRCm39) |
missense |
probably benign |
0.39 |
|
R6248:Or6c210
|
UTSW |
10 |
129,496,532 (GRCm39) |
missense |
probably benign |
0.39 |
|
R8094:Or6c210
|
UTSW |
10 |
129,495,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9013:Or6c210
|
UTSW |
10 |
129,495,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9224:Or6c210
|
UTSW |
10 |
129,496,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9390:Or6c210
|
UTSW |
10 |
129,495,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9726:Or6c210
|
UTSW |
10 |
129,495,920 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9777:Or6c210
|
UTSW |
10 |
129,495,705 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Posted On |
2014-05-07 |
Incidental Mutation