Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01944:Vmn1r197'

181191

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r197

Ensembl Gene

ENSMUSG00000069294

Gene Name

vomeronasal 1 receptor 197

Synonyms

V1rh21

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL01944

Quality Score

Status

Chromosome

Chromosomal Location

22512081-22512977 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 22512508 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 143 (N143S)

Ref Sequence

ENSEMBL: ENSMUSP00000154632 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091734] [ENSMUST00000226225] [ENSMUST00000227017]

AlphaFold

Q8R265

Predicted Effect

possibly damaging
Transcript: ENSMUST00000091734
AA Change: N143S

PolyPhen 2 Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000089328
Gene: ENSMUSG00000069294
AA Change: N143S

Domain	Start	End	E-Value	Type
transmembrane domain	10	29	N/A	INTRINSIC
Pfam:V1R	31	297	1.4e-40	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000226225
AA Change: N143S

PolyPhen 2 Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000227017
AA Change: N143S

PolyPhen 2 Score 0.775 (Sensitivity: 0.85; Specificity: 0.92)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd11	T	A	5: 135,040,230 (GRCm39)	V202D	probably damaging	Het
Afdn	A	G	17: 14,030,743 (GRCm39)	N218S	probably damaging	Het
Arhgef1	G	A	7: 24,625,208 (GRCm39)		probably null	Het
Atp1a2	G	T	1: 172,103,754 (GRCm39)	T959K	probably damaging	Het
Atp6v0a2	A	G	5: 124,774,043 (GRCm39)	E96G	probably benign	Het
B9d1	A	T	11: 61,403,205 (GRCm39)	M52L	probably benign	Het
Col6a6	T	A	9: 105,661,108 (GRCm39)	I334F	probably damaging	Het
Drd3	T	C	16: 43,638,671 (GRCm39)	F259L	probably benign	Het
Drosha	T	G	15: 12,889,805 (GRCm39)	L891R	probably damaging	Het
Ecpas	G	T	4: 58,861,544 (GRCm39)	T345K	probably benign	Het
Garin5b	T	C	7: 4,773,694 (GRCm39)	N67S	possibly damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Greb1l	T	C	18: 10,557,280 (GRCm39)	V1760A	possibly damaging	Het
Il36b	T	A	2: 24,045,291 (GRCm39)	W48R	probably damaging	Het
Ipo9	C	A	1: 135,333,624 (GRCm39)	V353F	probably damaging	Het
Kmt2a	A	T	9: 44,761,064 (GRCm39)	F126I	probably damaging	Het
Mmrn1	T	C	6: 60,948,167 (GRCm39)		probably null	Het
Nup214	T	A	2: 31,924,971 (GRCm39)	C328*	probably null	Het
Or9g19	A	G	2: 85,600,384 (GRCm39)	I80V	probably damaging	Het
Pcdh17	G	T	14: 84,684,960 (GRCm39)	V476L	probably benign	Het
Pcdh17	T	A	14: 84,684,961 (GRCm39)	V476E	probably damaging	Het
Prpf38b	A	T	3: 108,811,991 (GRCm39)	S291R	probably benign	Het
Rap1gap	T	C	4: 137,452,931 (GRCm39)	S601P	probably damaging	Het
Rnf213	T	C	11: 119,307,283 (GRCm39)	Y648H	probably benign	Het
Slfn3	A	G	11: 83,103,974 (GRCm39)	T282A	possibly damaging	Het
Ttll3	C	T	6: 113,391,076 (GRCm39)	T887I	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Xpo4	T	C	14: 57,841,855 (GRCm39)	I487V	probably benign	Het

Other mutations in Vmn1r197

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01459:Vmn1r197	APN	13	22,512,241 (GRCm39)	missense	probably benign	0.07
IGL02317:Vmn1r197	APN	13	22,512,073 (GRCm39)	utr 5 prime	probably benign
IGL02487:Vmn1r197	APN	13	22,512,792 (GRCm39)	missense	probably damaging	1.00
R0443:Vmn1r197	UTSW	13	22,512,241 (GRCm39)	missense	possibly damaging	0.90
R1511:Vmn1r197	UTSW	13	22,512,823 (GRCm39)	missense	possibly damaging	0.92
R1542:Vmn1r197	UTSW	13	22,512,520 (GRCm39)	missense	probably benign	0.01
R1617:Vmn1r197	UTSW	13	22,512,498 (GRCm39)	missense	possibly damaging	0.55
R1739:Vmn1r197	UTSW	13	22,512,541 (GRCm39)	missense	possibly damaging	0.80
R3739:Vmn1r197	UTSW	13	22,512,746 (GRCm39)	nonsense	probably null
R4761:Vmn1r197	UTSW	13	22,512,174 (GRCm39)	missense	probably benign	0.00
R5335:Vmn1r197	UTSW	13	22,512,361 (GRCm39)	missense	probably damaging	1.00
R6168:Vmn1r197	UTSW	13	22,512,678 (GRCm39)	missense	possibly damaging	0.65
R8056:Vmn1r197	UTSW	13	22,512,388 (GRCm39)	missense	probably damaging	1.00
R9282:Vmn1r197	UTSW	13	22,512,608 (GRCm39)	missense	possibly damaging	0.92
Z1177:Vmn1r197	UTSW	13	22,512,099 (GRCm39)	nonsense	probably null

Posted On

2014-05-07