Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02002:Or6c35'

183074

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6c35

Ensembl Gene

ENSMUSG00000095138

Gene Name

olfactory receptor family 6 subfamily C member 35

Synonyms

MOR114-6, Olfr781, GA_x6K02T2PULF-11013616-11014551

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02002

Quality Score

Status

Chromosome

Chromosomal Location

129168752-129169687 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 129168996 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 82 (I82K)

Ref Sequence

ENSEMBL: ENSMUSP00000145356 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075613] [ENSMUST00000204108]

AlphaFold

Q8VFZ8

Predicted Effect

probably damaging
Transcript: ENSMUST00000075613
AA Change: I82K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000075041
Gene: ENSMUSG00000095138
AA Change: I82K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	305	1.6e-44	PFAM
Pfam:7tm_1	38	287	5e-24	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000204108
AA Change: I82K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000145356
Gene: ENSMUSG00000095138
AA Change: I82K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	305	1.6e-44	PFAM
Pfam:7tm_1	38	287	5e-24	PFAM

Meta Mutation Damage Score

0.5990

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg5	G	T	17: 84,989,479 (GRCm39)	Y76*	probably null	Het
Acadsb	T	A	7: 131,030,258 (GRCm39)	V135E	probably damaging	Het
Acap1	A	G	11: 69,775,286 (GRCm39)	Y326H	probably damaging	Het
Actl11	T	A	9: 107,806,529 (GRCm39)	V284D	probably benign	Het
Adcy10	G	T	1: 165,349,412 (GRCm39)	D428Y	probably damaging	Het
Akap8	A	G	17: 32,528,470 (GRCm39)	C481R	probably damaging	Het
Amotl2	G	A	9: 102,602,316 (GRCm39)	A26T	probably damaging	Het
Apob	T	C	12: 8,044,822 (GRCm39)	V814A	probably benign	Het
Casp8ap2	T	A	4: 32,639,391 (GRCm39)	N148K	probably damaging	Het
Ccdc149	G	A	5: 52,563,421 (GRCm39)	T124M	probably damaging	Het
Cd320	A	G	17: 34,062,214 (GRCm39)		probably benign	Het
Clca4b	T	C	3: 144,638,194 (GRCm39)	T23A	probably benign	Het
Col22a1	A	G	15: 71,682,946 (GRCm39)		probably benign	Het
Col24a1	T	A	3: 145,062,699 (GRCm39)	F675I	possibly damaging	Het
Col6a3	A	G	1: 90,709,858 (GRCm39)		probably benign	Het
Dap3	A	T	3: 88,843,535 (GRCm39)	M19K	probably benign	Het
Dsg2	A	G	18: 20,712,233 (GRCm39)	D123G	probably damaging	Het
Dysf	T	A	6: 84,187,769 (GRCm39)		probably benign	Het
Erbb4	A	G	1: 68,119,885 (GRCm39)	S853P	probably damaging	Het
Fbn2	A	G	18: 58,247,625 (GRCm39)	M423T	probably benign	Het
Fcgbpl1	A	T	7: 27,852,221 (GRCm39)	Y1248F	probably damaging	Het
Fgfr1	T	C	8: 26,045,727 (GRCm39)	Y112H	probably damaging	Het
Gbp7	G	A	3: 142,244,661 (GRCm39)	A203T	probably damaging	Het
Gon4l	C	T	3: 88,802,643 (GRCm39)	P1085S	possibly damaging	Het
Gsdma2	T	C	11: 98,541,800 (GRCm39)	F176L	probably damaging	Het
Haghl	A	G	17: 26,003,239 (GRCm39)	F131S	probably damaging	Het
Hmcn1	G	A	1: 150,491,049 (GRCm39)	P4167S	probably damaging	Het
Hscb	T	C	5: 110,978,820 (GRCm39)	N199D	probably benign	Het
Lmbr1l	T	A	15: 98,802,666 (GRCm39)	N428Y	probably damaging	Het
Mc2r	T	A	18: 68,540,505 (GRCm39)	M263L	probably benign	Het
Metap1	T	A	3: 138,168,150 (GRCm39)	T325S	probably damaging	Het
Mff	A	G	1: 82,719,696 (GRCm39)	R225G	probably damaging	Het
Naprt	A	T	15: 75,763,221 (GRCm39)	L474Q	probably damaging	Het
Nin	A	T	12: 70,109,473 (GRCm39)	Y155*	probably null	Het
Nrg3	A	T	14: 38,092,724 (GRCm39)	C612*	probably null	Het
Or2aj5	T	C	16: 19,425,300 (GRCm39)	I39M	possibly damaging	Het
Or5p52	A	T	7: 107,502,497 (GRCm39)	D191V	possibly damaging	Het
Pdilt	A	T	7: 119,099,667 (GRCm39)	F200L	probably damaging	Het
Ppard	T	G	17: 28,517,877 (GRCm39)	F315C	probably damaging	Het
Ror1	T	A	4: 100,298,381 (GRCm39)	S585T	probably damaging	Het
Spdye4a	T	A	5: 143,211,460 (GRCm39)	I35F	possibly damaging	Het
Tenm2	T	C	11: 36,097,922 (GRCm39)	K442R	probably benign	Het
Tln2	A	G	9: 67,263,980 (GRCm39)	I553T	probably damaging	Het
Tmem269	T	A	4: 119,071,338 (GRCm39)	I26F	probably benign	Het
Tsen2	T	C	6: 115,536,568 (GRCm39)	V108A	probably benign	Het
Ttyh3	A	T	5: 140,615,238 (GRCm39)	D383E	probably damaging	Het
Tut7	A	G	13: 59,929,910 (GRCm39)	S1042P	possibly damaging	Het
Usp13	T	C	3: 32,901,974 (GRCm39)	S102P	probably damaging	Het
Vmn2r118	T	G	17: 55,899,619 (GRCm39)	S762R	probably damaging	Het
Washc4	A	G	10: 83,415,407 (GRCm39)	N799S	possibly damaging	Het
Zdhhc17	C	T	10: 110,803,550 (GRCm39)	V256I	probably benign	Het
Zfp51	T	A	17: 21,684,221 (GRCm39)	F279I	probably damaging	Het
Zzz3	A	G	3: 152,157,006 (GRCm39)	T223A	probably damaging	Het

Other mutations in Or6c35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01121:Or6c35	APN	10	129,168,804 (GRCm39)	missense	probably benign
IGL01636:Or6c35	APN	10	129,168,752 (GRCm39)	start codon destroyed	probably damaging	0.96
IGL01744:Or6c35	APN	10	129,169,326 (GRCm39)	missense	probably benign	0.05
IGL01867:Or6c35	APN	10	129,169,232 (GRCm39)	missense	probably damaging	1.00
IGL02423:Or6c35	APN	10	129,169,397 (GRCm39)	missense	probably benign	0.00
R2036:Or6c35	UTSW	10	129,169,541 (GRCm39)	missense	probably benign	0.43
R2099:Or6c35	UTSW	10	129,169,152 (GRCm39)	missense	probably damaging	0.96
R2273:Or6c35	UTSW	10	129,169,326 (GRCm39)	missense	probably benign	0.05
R2274:Or6c35	UTSW	10	129,169,326 (GRCm39)	missense	probably benign	0.05
R3841:Or6c35	UTSW	10	129,169,202 (GRCm39)	missense	probably benign	0.00
R4585:Or6c35	UTSW	10	129,169,142 (GRCm39)	missense	probably benign	0.08
R4586:Or6c35	UTSW	10	129,169,142 (GRCm39)	missense	probably benign	0.08
R5522:Or6c35	UTSW	10	129,168,798 (GRCm39)	missense	probably damaging	0.98
R6052:Or6c35	UTSW	10	129,169,071 (GRCm39)	missense	possibly damaging	0.91
R6414:Or6c35	UTSW	10	129,169,578 (GRCm39)	missense	probably benign	0.23
R6468:Or6c35	UTSW	10	129,169,580 (GRCm39)	missense	possibly damaging	0.91
R6647:Or6c35	UTSW	10	129,169,033 (GRCm39)	nonsense	probably null
R8099:Or6c35	UTSW	10	129,168,996 (GRCm39)	missense	probably damaging	0.99
R9151:Or6c35	UTSW	10	129,169,623 (GRCm39)	missense	probably damaging	1.00
R9617:Or6c35	UTSW	10	129,168,794 (GRCm39)	missense	probably damaging	0.98
R9649:Or6c35	UTSW	10	129,169,368 (GRCm39)	missense	possibly damaging	0.68
T0975:Or6c35	UTSW	10	129,169,314 (GRCm39)	missense	probably benign	0.31

Posted On

2014-05-07