Incidental Mutation 'R2061:Lekr1'
ID 228688
Institutional Source Beutler Lab
Gene Symbol Lekr1
Ensembl Gene ENSMUSG00000074579
Gene Name leucine, glutamate and lysine rich 1
Synonyms Gm6534, EG546798
MMRRC Submission 040066-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.407) question?
Stock # R2061 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 65573649-65738776 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to C at 65632860 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s):
AlphaFold A0A571BF98
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161534
SMART Domains Protein: ENSMUSP00000124130
Gene: ENSMUSG00000074579

DomainStartEndE-ValueType
coiled coil region 32 123 N/A INTRINSIC
coiled coil region 191 275 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161794
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161851
SMART Domains Protein: ENSMUSP00000124508
Gene: ENSMUSG00000074579

DomainStartEndE-ValueType
coiled coil region 32 123 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177434
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.8%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 4 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Gabra1 A T 11: 42,024,625 (GRCm39) probably benign Het
Mavs G T 2: 131,082,226 (GRCm39) probably benign Het
Nav2 C T 7: 49,248,645 (GRCm39) probably benign Het
Obi1 A G 14: 104,759,968 (GRCm39) probably benign Het
Other mutations in Lekr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01701:Lekr1 APN 3 65,591,425 (GRCm39) missense probably damaging 1.00
R1652:Lekr1 UTSW 3 65,591,508 (GRCm39) missense probably benign 0.02
R3086:Lekr1 UTSW 3 65,634,581 (GRCm39) exon noncoding transcript
R4572:Lekr1 UTSW 3 65,691,336 (GRCm39) exon noncoding transcript
R5073:Lekr1 UTSW 3 65,727,215 (GRCm39) splice site noncoding transcript
R5398:Lekr1 UTSW 3 65,688,807 (GRCm39) exon noncoding transcript
R5547:Lekr1 UTSW 3 65,576,601 (GRCm39) critical splice donor site probably null
R5947:Lekr1 UTSW 3 65,680,498 (GRCm39) splice site noncoding transcript
R6713:Lekr1 UTSW 3 65,591,380 (GRCm39) missense probably benign 0.10
R8387:Lekr1 UTSW 3 65,591,520 (GRCm39) missense possibly damaging 0.50
R9129:Lekr1 UTSW 3 65,591,426 (GRCm39) nonsense probably null
R9528:Lekr1 UTSW 3 65,591,608 (GRCm39) missense unknown
Predicted Primers
Posted On 2014-09-17