Incidental Mutation 'R2423:Trp53tg5'
ID 249426
Institutional Source Beutler Lab
Gene Symbol Trp53tg5
Ensembl Gene ENSMUSG00000017720
Gene Name transformation related protein 53 target 5
Synonyms 1700126L10Rik
MMRRC Submission 040385-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R2423 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 164312221-164315644 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 164313250 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 142 (R142*)
Ref Sequence ENSEMBL: ENSMUSP00000017864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017864] [ENSMUST00000125086] [ENSMUST00000138268] [ENSMUST00000142892] [ENSMUST00000164863]
AlphaFold Q9D976
Predicted Effect probably null
Transcript: ENSMUST00000017864
AA Change: R142*
SMART Domains Protein: ENSMUSP00000017864
Gene: ENSMUSG00000017720
AA Change: R142*

DomainStartEndE-ValueType
Pfam:TP53IP5 28 238 2e-97 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125086
SMART Domains Protein: ENSMUSP00000121900
Gene: ENSMUSG00000045503

DomainStartEndE-ValueType
Pfam:SYS1 5 148 9.2e-61 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138268
SMART Domains Protein: ENSMUSP00000117507
Gene: ENSMUSG00000045503

DomainStartEndE-ValueType
Pfam:SYS1 5 76 1.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142892
SMART Domains Protein: ENSMUSP00000114360
Gene: ENSMUSG00000045503

DomainStartEndE-ValueType
Pfam:SYS1 5 76 1.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164863
SMART Domains Protein: ENSMUSP00000126658
Gene: ENSMUSG00000090996

DomainStartEndE-ValueType
Pfam:SYS1 5 78 6.7e-22 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amer2 T C 14: 60,616,656 (GRCm39) S284P possibly damaging Het
Ap5z1 T C 5: 142,462,532 (GRCm39) V614A probably benign Het
Arhgap9 A T 10: 127,162,993 (GRCm39) probably null Het
Brf1 G A 12: 112,963,819 (GRCm39) A53V probably benign Het
Cyp1a2 C T 9: 57,587,232 (GRCm39) R353Q probably damaging Het
Deup1 G T 9: 15,503,754 (GRCm39) S269* probably null Het
F11r T A 1: 171,289,191 (GRCm39) Y218N possibly damaging Het
Gjd4 G T 18: 9,280,811 (GRCm39) S89* probably null Het
Mapkbp1 A T 2: 119,855,071 (GRCm39) E1430V probably benign Het
Mga A G 2: 119,795,274 (GRCm39) K2986R probably damaging Het
Myo9b G T 8: 71,780,584 (GRCm39) V494L probably damaging Het
Nbea G A 3: 55,992,727 (GRCm39) T293I probably damaging Het
Neto2 C T 8: 86,396,396 (GRCm39) R83Q probably damaging Het
Ocm A T 5: 143,961,388 (GRCm39) probably null Het
Or52z14 C T 7: 103,253,241 (GRCm39) R127C probably benign Het
Pcdha11 T C 18: 37,140,477 (GRCm39) I702T possibly damaging Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Rbbp8nl A T 2: 179,922,764 (GRCm39) S210T probably damaging Het
Rbl2 A T 8: 91,813,774 (GRCm39) I340F probably benign Het
Rft1 T C 14: 30,388,724 (GRCm39) L216P possibly damaging Het
Slc26a10 T A 10: 127,015,606 (GRCm39) probably null Het
Slc34a1 G A 13: 55,556,865 (GRCm39) A235T possibly damaging Het
Spag17 A G 3: 100,010,772 (GRCm39) T2089A probably benign Het
Srek1 G C 13: 103,889,536 (GRCm39) S260* probably null Het
Sspo T C 6: 48,430,989 (GRCm39) V624A probably benign Het
Tapt1 T C 5: 44,349,795 (GRCm39) I251V probably benign Het
Tmem248 T C 5: 130,258,403 (GRCm39) I32T probably damaging Het
Tnk1 T G 11: 69,746,587 (GRCm39) T209P probably damaging Het
Trip12 TATACATACATACATACATACATACATACATAC TATACATACATACATACATACATACATACATACATAC 1: 84,792,511 (GRCm39) probably null Het
Upf1 C T 8: 70,791,110 (GRCm39) R544H probably damaging Het
Vldlr C T 19: 27,213,688 (GRCm39) T125I possibly damaging Het
Vps8 A G 16: 21,378,087 (GRCm39) T1033A probably benign Het
Wiz A C 17: 32,580,859 (GRCm39) H197Q probably damaging Het
Other mutations in Trp53tg5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02387:Trp53tg5 APN 2 164,313,376 (GRCm39) missense possibly damaging 0.75
R0538:Trp53tg5 UTSW 2 164,313,401 (GRCm39) missense probably damaging 0.98
R1348:Trp53tg5 UTSW 2 164,315,521 (GRCm39) critical splice donor site probably null
R2216:Trp53tg5 UTSW 2 164,313,226 (GRCm39) missense probably benign 0.00
R3034:Trp53tg5 UTSW 2 164,313,219 (GRCm39) missense probably benign 0.00
R5569:Trp53tg5 UTSW 2 164,313,256 (GRCm39) missense probably benign 0.00
R5842:Trp53tg5 UTSW 2 164,313,289 (GRCm39) missense possibly damaging 0.56
R6021:Trp53tg5 UTSW 2 164,313,391 (GRCm39) missense probably benign 0.00
R7206:Trp53tg5 UTSW 2 164,313,378 (GRCm39) missense probably damaging 1.00
R7366:Trp53tg5 UTSW 2 164,313,027 (GRCm39) missense possibly damaging 0.78
R9705:Trp53tg5 UTSW 2 164,313,208 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATCTACACATGATCCGGCGC -3'
(R):5'- AGCCTTAATCTGCTGATGGTC -3'

Sequencing Primer
(F):5'- TATGCGTGTGGGAAGCCC -3'
(R):5'- AATCTGCTGATGGTCTTTCTTCTC -3'
Posted On 2014-11-12