Incidental Mutation 'R3237:Lyzl4'
ID 259103
Institutional Source Beutler Lab
Gene Symbol Lyzl4
Ensembl Gene ENSMUSG00000032530
Gene Name lysozyme-like 4
Synonyms 1810009N24Rik, LYC4
MMRRC Submission 040619-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R3237 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 121406909-121471162 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 121413233 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 65 (D65G)
Ref Sequence ENSEMBL: ENSMUSP00000115284 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077706] [ENSMUST00000120918] [ENSMUST00000125075] [ENSMUST00000213757] [ENSMUST00000214592]
AlphaFold Q9D925
Predicted Effect probably benign
Transcript: ENSMUST00000077706
AA Change: D65G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000076887
Gene: ENSMUSG00000032530
AA Change: D65G

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 144 1.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120918
AA Change: D65G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000113034
Gene: ENSMUSG00000032530
AA Change: D65G

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 144 1.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125075
AA Change: D65G

PolyPhen 2 Score 0.176 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000115284
Gene: ENSMUSG00000032530
AA Change: D65G

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 91 6.48e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128080
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156364
Predicted Effect probably benign
Transcript: ENSMUST00000213757
AA Change: D65G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000214592
AA Change: D65G

PolyPhen 2 Score 0.146 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Aff2 T A X: 68,907,543 (GRCm39) V1175E possibly damaging Het
Agbl3 A G 6: 34,800,022 (GRCm39) probably null Het
Bcar3 C A 3: 122,318,645 (GRCm39) Q678K probably benign Het
Ccm2 G A 11: 6,520,090 (GRCm39) V53I probably benign Het
Cd3e G T 9: 44,913,608 (GRCm39) C42* probably null Het
Cd4 A T 6: 124,844,633 (GRCm39) I384N probably benign Het
Ceacam11 T A 7: 17,707,379 (GRCm39) F54L probably benign Het
Cfap46 A G 7: 139,197,506 (GRCm39) S2122P probably damaging Het
Clptm1 A G 7: 19,369,271 (GRCm39) S461P probably damaging Het
Dlat T C 9: 50,549,331 (GRCm39) T518A possibly damaging Het
Dnah17 T C 11: 117,985,680 (GRCm39) T1466A probably benign Het
Dnah9 G A 11: 65,845,815 (GRCm39) T3023I probably benign Het
Fam181a T G 12: 103,282,348 (GRCm39) C84W possibly damaging Het
Gask1a C T 9: 121,793,935 (GRCm39) P30S possibly damaging Het
H2-Q6 C A 17: 35,644,676 (GRCm39) T155K probably damaging Het
Hlx G T 1: 184,464,184 (GRCm39) A52D probably damaging Het
Inpp5b A G 4: 124,674,279 (GRCm39) R329G probably benign Het
Klrb1f A T 6: 129,031,306 (GRCm39) I168L possibly damaging Het
Lama4 A T 10: 38,973,175 (GRCm39) I1581F probably damaging Het
Lipn A G 19: 34,046,138 (GRCm39) N37S probably benign Het
Med29 A G 7: 28,092,046 (GRCm39) probably benign Het
Myrip C A 9: 120,270,473 (GRCm39) D574E possibly damaging Het
N4bp3 A T 11: 51,536,761 (GRCm39) F104Y probably damaging Het
Nlrp9a A T 7: 26,270,810 (GRCm39) K892* probably null Het
Nsd1 T A 13: 55,460,701 (GRCm39) H2309Q possibly damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Optn T C 2: 5,039,014 (GRCm39) S370G probably damaging Het
Pbrm1 T C 14: 30,754,432 (GRCm39) F151L probably damaging Het
Plekhs1 A T 19: 56,453,032 (GRCm39) probably null Het
Rpn1 A G 6: 88,080,396 (GRCm39) K565R probably benign Het
Rrh T C 3: 129,605,360 (GRCm39) Y110C probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr1 C T 7: 28,769,075 (GRCm39) probably null Het
Scai C T 2: 39,040,326 (GRCm39) probably benign Het
Scap C G 9: 110,208,650 (GRCm39) P564A probably damaging Het
Setdb1 A G 3: 95,246,065 (GRCm39) V619A probably damaging Het
Slc41a3 T C 6: 90,613,847 (GRCm39) Y226H probably benign Het
Slf2 A G 19: 44,930,773 (GRCm39) I617V probably benign Het
Sned1 G A 1: 93,186,725 (GRCm39) R180Q probably benign Het
Spata22 T A 11: 73,236,713 (GRCm39) F340I probably damaging Het
St8sia3 T C 18: 64,402,886 (GRCm39) F175S probably damaging Het
Supt20 T C 3: 54,616,501 (GRCm39) S253P possibly damaging Het
Syngap1 T A 17: 27,176,067 (GRCm39) Y118* probably null Het
Szt2 A C 4: 118,240,231 (GRCm39) probably null Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Uba3 G T 6: 97,163,201 (GRCm39) T319K probably damaging Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Zc3hav1 A G 6: 38,296,650 (GRCm39) L751S probably damaging Het
Zfp804b T C 5: 6,819,239 (GRCm39) M1275V probably benign Het
Zgrf1 A G 3: 127,407,024 (GRCm39) D1597G probably damaging Het
Other mutations in Lyzl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3428:Lyzl4 UTSW 9 121,413,195 (GRCm39) missense probably null 0.98
R3916:Lyzl4 UTSW 9 121,412,101 (GRCm39) missense probably damaging 1.00
R3917:Lyzl4 UTSW 9 121,412,101 (GRCm39) missense probably damaging 1.00
R4868:Lyzl4 UTSW 9 121,412,075 (GRCm39) missense probably damaging 0.99
R5589:Lyzl4 UTSW 9 121,413,469 (GRCm39) missense probably damaging 1.00
R5945:Lyzl4 UTSW 9 121,413,529 (GRCm39) missense unknown
R6343:Lyzl4 UTSW 9 121,407,150 (GRCm39) missense possibly damaging 0.71
R6943:Lyzl4 UTSW 9 121,412,047 (GRCm39) nonsense probably null
R8071:Lyzl4 UTSW 9 121,407,160 (GRCm39) nonsense probably null
R9631:Lyzl4 UTSW 9 121,413,055 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- AAGGTCTGTAGGCTCCTGTG -3'
(R):5'- ACTGTGAGTAGGACCCTTTCG -3'

Sequencing Primer
(F):5'- TCCTGTGCCCTGAAGGACTG -3'
(R):5'- CGGGCCATCTCTCTCTCAC -3'
Posted On 2015-01-23