Incidental Mutation 'R3786:Rala'
ID 272273
Institutional Source Beutler Lab
Gene Symbol Rala
Ensembl Gene ENSMUSG00000008859
Gene Name v-ral simian leukemia viral oncogene A (ras related)
Synonyms Rasl1, 3010001O15Rik, Ral
MMRRC Submission 040753-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3786 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 18055160-18118802 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18057031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 185 (E185V)
Ref Sequence ENSEMBL: ENSMUSP00000009003 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009003]
AlphaFold P63321
Predicted Effect probably benign
Transcript: ENSMUST00000009003
AA Change: E185V

PolyPhen 2 Score 0.202 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000009003
Gene: ENSMUSG00000008859
AA Change: E185V

DomainStartEndE-ValueType
RAS 12 178 8.4e-104 SMART
low complexity region 179 193 N/A INTRINSIC
Meta Mutation Damage Score 0.0830 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete preweaning lethality and exencephaly. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 T A 3: 97,066,605 (GRCm39) L41Q probably damaging Het
Aoc1 T C 6: 48,882,589 (GRCm39) L177P probably damaging Het
Btbd7 C T 12: 102,804,411 (GRCm39) E210K probably benign Het
C1qtnf12 G A 4: 156,050,356 (GRCm39) R231H probably damaging Het
Cenpf T A 1: 189,390,534 (GRCm39) E1099D probably damaging Het
Dennd3 T C 15: 73,419,426 (GRCm39) V739A possibly damaging Het
Dmxl1 G A 18: 49,998,189 (GRCm39) S763N probably damaging Het
Dzip3 C A 16: 48,795,906 (GRCm39) C155F probably benign Het
Fam161b A T 12: 84,408,464 (GRCm39) probably null Het
Fancd2 T G 6: 113,542,165 (GRCm39) S770A probably damaging Het
Gpt2 G T 8: 86,252,202 (GRCm39) V506L probably benign Het
Hao2 T A 3: 98,784,068 (GRCm39) E327V probably damaging Het
Heatr1 G T 13: 12,449,341 (GRCm39) L1946F probably damaging Het
Hnrnpl A G 7: 28,510,436 (GRCm39) probably benign Het
Itgb1 T A 8: 129,439,839 (GRCm39) I176N probably damaging Het
Kif13b C T 14: 65,037,849 (GRCm39) T1505I probably benign Het
Magi2 C T 5: 20,670,907 (GRCm39) T580M probably damaging Het
Mettl3 A T 14: 52,537,363 (GRCm39) I102N probably benign Het
Mgat4c A G 10: 102,220,931 (GRCm39) H71R probably damaging Het
Misp G A 10: 79,661,795 (GRCm39) V71I probably benign Het
Muc2 A G 7: 141,283,590 (GRCm39) Q734R probably benign Het
Muc5b C T 7: 141,418,853 (GRCm39) T3933I possibly damaging Het
Myh13 A G 11: 67,218,014 (GRCm39) N29S probably benign Het
Myo15a A T 11: 60,368,398 (GRCm39) Y386F probably damaging Het
Neb C A 2: 52,091,927 (GRCm39) V5046F probably damaging Het
Neurod1 T A 2: 79,284,939 (GRCm39) N148I probably damaging Het
Nrg1 A T 8: 32,311,411 (GRCm39) V376E probably damaging Het
Nsa2 G T 13: 97,272,042 (GRCm39) Q60K possibly damaging Het
Odr4 A G 1: 150,260,282 (GRCm39) I112T probably benign Het
Ppp1r21 T A 17: 88,884,555 (GRCm39) probably null Het
Rhoc T C 3: 104,700,003 (GRCm39) probably null Het
Robo3 A G 9: 37,333,521 (GRCm39) V708A probably damaging Het
Rtcb G T 10: 85,778,458 (GRCm39) T395K possibly damaging Het
Rttn A G 18: 89,056,018 (GRCm39) T967A probably benign Het
Sacs C A 14: 61,421,410 (GRCm39) Q116K probably damaging Het
Smarca4 A G 9: 21,583,355 (GRCm39) H1062R possibly damaging Het
Spatc1l C T 10: 76,399,736 (GRCm39) T86I probably benign Het
Thbs4 T C 13: 92,909,672 (GRCm39) N375S probably benign Het
Tsc1 A G 2: 28,577,154 (GRCm39) D1151G probably damaging Het
Ttll1 T C 15: 83,368,419 (GRCm39) D413G probably benign Het
Wap G A 11: 6,588,550 (GRCm39) Q25* probably null Het
Wnt16 A G 6: 22,298,021 (GRCm39) N296D probably benign Het
Other mutations in Rala
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0165:Rala UTSW 13 18,063,174 (GRCm39) missense probably benign 0.00
R0537:Rala UTSW 13 18,063,233 (GRCm39) missense probably benign 0.00
R3783:Rala UTSW 13 18,057,031 (GRCm39) missense probably benign 0.20
R3784:Rala UTSW 13 18,057,031 (GRCm39) missense probably benign 0.20
R3787:Rala UTSW 13 18,057,031 (GRCm39) missense probably benign 0.20
R3839:Rala UTSW 13 18,067,759 (GRCm39) missense probably damaging 0.99
R5881:Rala UTSW 13 18,067,746 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAGTTCCAATTCATGCTTTTAGTG -3'
(R):5'- TGACTGAGCGTTTGCCATCC -3'

Sequencing Primer
(F):5'- TGGTCAGGTCAGGATAAG -3'
(R):5'- GAGCGTTTGCCATCCTGTGC -3'
Posted On 2015-03-25