Incidental Mutation 'IGL02103:Vmn1r226'
ID279828
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r226
Ensembl Gene ENSMUSG00000042848
Gene Namevomeronasal 1 receptor 226
SynonymsV1re2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL02103
Quality Score
Status
Chromosome17
Chromosomal Location20687508-20688404 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 20687664 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 53 (S53P)
Ref Sequence ENSEMBL: ENSMUSP00000058266 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061756]
Predicted Effect probably damaging
Transcript: ENSMUST00000061756
AA Change: S53P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000058266
Gene: ENSMUSG00000042848
AA Change: S53P

DomainStartEndE-ValueType
Pfam:TAS2R 1 286 5.2e-12 PFAM
Pfam:7tm_1 22 285 9.1e-7 PFAM
Pfam:V1R 33 292 8.7e-26 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd4 G A 12: 84,612,364 T206M probably benign Het
Adcy3 T A 12: 4,134,390 V22D possibly damaging Het
Alb G A 5: 90,464,131 E140K probably benign Het
Aph1a G A 3: 95,895,813 V193I probably damaging Het
Asb2 G A 12: 103,333,496 R178* probably null Het
Celf3 A T 3: 94,486,801 Q137L probably damaging Het
Cmya5 T C 13: 93,092,127 D2151G probably benign Het
Cuedc1 T A 11: 88,188,799 S353T probably damaging Het
Dlg5 A C 14: 24,144,346 L1709R probably damaging Het
Dst T C 1: 34,190,118 I1939T possibly damaging Het
Emx2 A T 19: 59,461,698 N149I probably benign Het
Fancm A G 12: 65,095,784 D472G probably benign Het
Fasn T C 11: 120,811,936 Y1700C probably damaging Het
Fat2 T A 11: 55,289,296 R1406S probably damaging Het
Fat4 C A 3: 38,889,199 T747K probably damaging Het
Fer A G 17: 64,138,928 M795V probably benign Het
Gm5916 A G 9: 36,128,674 L6P probably damaging Het
Gpr139 A G 7: 119,145,132 F77L possibly damaging Het
Kcnu1 T C 8: 25,905,948 S654P possibly damaging Het
Kdm5c T A X: 152,248,766 F408L probably damaging Het
Kel A G 6: 41,702,389 S147P probably benign Het
Klra5 A T 6: 129,911,344 probably null Het
Mastl A G 2: 23,139,998 S239P probably benign Het
Med18 A T 4: 132,459,666 V174D probably damaging Het
Mgat4a A T 1: 37,462,926 M247K possibly damaging Het
Mx2 A C 16: 97,544,595 D71A probably damaging Het
Nxt1 G T 2: 148,675,644 E102* probably null Het
Olfr125 A G 17: 37,835,278 Q93R possibly damaging Het
Olfr410 A G 11: 74,335,036 F65S probably damaging Het
Olfr828 T C 9: 18,815,709 N195S probably damaging Het
Pcdhb16 T A 18: 37,480,108 V707E probably benign Het
Pdzrn4 T A 15: 92,769,887 V640E probably damaging Het
Piwil4 T C 9: 14,725,986 probably null Het
Pla2g4a A T 1: 149,901,199 D55E probably damaging Het
Plekhg2 C A 7: 28,360,076 R1276L probably damaging Het
Psd4 G A 2: 24,400,528 W539* probably null Het
Rae1 G A 2: 173,003,513 E33K probably damaging Het
Rbm12b1 T A 4: 12,145,563 F512I probably damaging Het
Rfx6 A G 10: 51,726,856 D823G possibly damaging Het
Samt3 A T X: 86,047,153 Q217L probably damaging Het
Selenbp2 A G 3: 94,698,131 N134S probably null Het
Selenoo T C 15: 89,099,970 V663A probably damaging Het
Sp4 G T 12: 118,299,549 T254N probably damaging Het
Spdya A G 17: 71,578,247 K232R probably benign Het
Stom A T 2: 35,320,389 V201E probably benign Het
Sycp3 A G 10: 88,466,472 K108R possibly damaging Het
Usp2 A G 9: 44,089,128 probably benign Het
Vmn2r14 C T 5: 109,224,483 G47D probably damaging Het
Vwf T G 6: 125,646,355 L1805W probably damaging Het
Washc3 A T 10: 88,201,825 Q22L probably damaging Het
Wdr81 T A 11: 75,444,720 D1761V probably damaging Het
Other mutations in Vmn1r226
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Vmn1r226 APN 17 20687904 missense probably damaging 1.00
IGL03394:Vmn1r226 APN 17 20688184 missense probably benign 0.00
R0243:Vmn1r226 UTSW 17 20687577 missense probably benign 0.00
R0605:Vmn1r226 UTSW 17 20687871 missense probably benign 0.12
R1463:Vmn1r226 UTSW 17 20687732 missense probably benign 0.00
R1571:Vmn1r226 UTSW 17 20688276 missense probably damaging 0.97
R1677:Vmn1r226 UTSW 17 20688073 missense probably damaging 1.00
R1917:Vmn1r226 UTSW 17 20687580 missense probably damaging 0.99
R1918:Vmn1r226 UTSW 17 20687580 missense probably damaging 0.99
R1919:Vmn1r226 UTSW 17 20687580 missense probably damaging 0.99
R1980:Vmn1r226 UTSW 17 20688046 missense possibly damaging 0.81
R2291:Vmn1r226 UTSW 17 20688213 missense probably damaging 1.00
R2377:Vmn1r226 UTSW 17 20687730 missense probably benign 0.05
R3878:Vmn1r226 UTSW 17 20687998 missense possibly damaging 0.79
R5166:Vmn1r226 UTSW 17 20687863 missense probably benign 0.43
R6510:Vmn1r226 UTSW 17 20687853 missense probably benign 0.37
R6599:Vmn1r226 UTSW 17 20688289 missense probably benign 0.01
R7304:Vmn1r226 UTSW 17 20687749 missense probably damaging 1.00
X0066:Vmn1r226 UTSW 17 20688250 missense probably damaging 0.99
Posted On2015-04-16